Results 101 to 110 of about 2,701,183 (228)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Identification Robust Confidence Sets Methods for Inference on Parameter Ratios and their Application to Estimating Value-of-Time [PDF]
The problem of constructing confidence set estimates for parameter ratios arises in a variety of econometrics contexts; these include value-of-time estimation in transportation research and inference on elasticities given several model specifications ...
Lynda Khalaf +2 more
core
Una introducción a la investigación webmétrica de empresas [PDF]
Gestión Joven, 2009 La Web ha experimentado un enorme desarrollo en los últimos 20 años. La Webmetría se presenta como una nueva disciplina que pretende estudiar desde un punto de vista cuantitativo este nuevo canal de comunicación mediante la adaptación y aplicación de ...
Romero Frías, Esteban
doaj
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Elemental ratios link environmental change and human health
, 2019 Humans have fundamentally altered the cycling of multiple elements on a global scale. These changes impact the structure and function of terrestrial and aquatic ecosystems, with many implications for human health.
Bratt, Anika R. +5 more
core +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Applied SciencesIsokinetic dynamometry is considered the gold standard for assessing muscle strength ratios, whereas tensiomyography (TMG) has emerged as a promising tool for rapid assessment of involuntary muscle contractility.
Daša Weber, Ajda Hrastnik, Alan Kacin
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Stock Returns and Equity Premium Evidence Using Dividend Price Ratios and Dividend Yields in Malaysia [PDF]
The empirical findings of Goyal and Welch (2003) and Cochrane (2006) suggested that dividend yields and dividend ratios are robust predictors of annual stock returns and annual equity premia. However, Goyal and Welch (2003) asserted that many researchers
David E Allen, Imbarine Bujang
core