Results 1 to 10 of about 4,021,770 (291)

Reversible middle cerebral artery occlusion without craniectomy in rats.

Stroke, 1989
To develop a simple, relatively noninvasive small-animal model of reversible regional cerebral ischemia, we tested various methods of inducing infarction in the territory of the right middle cerebral artery (MCA) by extracranial vascular occlusion in ...
Enrique Zea Longa, P. Weinstein, Sara G. Carlson   +2 more
semanticscholar   +1 more source

The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans.

Cerebral Cortex, 2000
This paper reviews architectonic subdivisions and connections of the orbital and medial prefrontal cortex (OMPFC) in rats, monkeys and humans. Cortico-cortical connections provide the basis for recognition of 'medial' and 'orbital' networks within the ...
D. Öngür, J. Price
semanticscholar   +1 more source

Streptozotocin‐Induced Diabetic Models in Mice and Rats

Current Protocols in Pharmacology, 2015
Streptozotocin (STZ) is an antibiotic that produces pancreatic islet β‐cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM).
B. Furman
semanticscholar   +1 more source

The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice

Scientific Reports, 2018
Clozapine-N-oxide (CNO) has long been the ligand of choice for selectively activating Designer Receptors Exclusively Activated by Designer Drugs (DREADDs).
D. F. Manvich, Kevin A. Webster, S. Foster, M. Farrell, J. Ritchie, J. Porter, D. Weinshenker   +6 more
semanticscholar   +1 more source

Estrogen Rapidly Enhances Incisional Pain of Ovariectomized Rats Primarily through the G Protein-Coupled Estrogen Receptor

International Journal of Molecular Sciences, 2014
It has become increasingly apparent that the pain threshold of females and males varies in an estrogen dependent manner. To investigate the modulation of pain by estrogen and the molecular mechanisms involved in this process.
Guanghui An, Wenhui Li, Tao Yan, Shitong Li   +3 more
semanticscholar   +1 more source

High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation

Scientific Reports, 2019
The main objective of this experiment was to determine the effects of yogurt supplementation on fat deposition, oxidative stress, inflammation and fibrosis in the liver of rats with high-fat (HF) diet-induced obesity.
Shoumen Lasker, Md. Mizanur Rahman, Faisal Parvez, Mushfera Zamila, Pintu Miah, K. Nahar, Fariha Kabir, Surovi Binte Sharmin, Nusrat Subhan, G. Ahsan, M. A. Alam   +10 more
semanticscholar   +1 more source

Alterations in the gut microbiota can elicit hypertension in rats.

Physiological Genomics, 2017
Gut dysbiosis has been linked to cardiovascular diseases including hypertension. We tested the hypothesis that hypertension could be induced in a normotensive strain of rats or attenuated in a hypertensive strain of rats by exchanging the gut microbiota ...
Sareema Adnan, J. Nelson, N. Ajami, V. Venna, J. Petrosino, R. Bryan, David J. Durgan   +6 more
semanticscholar   +1 more source

Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury.

Journal of Neurosurgery, 2015
OBJECT Transplanted multipotent mesenchymal stromal cells (MSCs) improve functional recovery in rats after traumatic brain injury (TBI). In this study the authors tested a novel hypothesis that systemic administration of cell-free exosomes generated from
Yanlu Zhang, M. Chopp, Yuling Meng, M. Katakowski, Hongqi Xin, A. Mahmood, Y. Xiong   +6 more
semanticscholar   +1 more source

Female rats are not more variable than male rats: a meta-analysis of neuroscience studies

Biology of Sex Differences, 2016
BackgroundNot including female rats or mice in neuroscience research has been justified due to the variable nature of female data caused by hormonal fluctuations associated with the female reproductive cycle. In this study, we investigated whether female
J. Becker, B. Prendergast, Jing W. Liang
semanticscholar   +1 more source

Therapeutic Benefit of Intravenous Administration of Bone Marrow Stromal Cells After Cerebral Ischemia in Rats

Stroke, 2001
Background and Purpose— We tested the hypothesis that intravenous infusion of bone marrow derived-marrow stromal cells (MSCs) enter the brain and reduce neurological functional deficits after stroke in rats. Methods— Rats (n=32) were subjected to 2 hours
Jieli Chen, Yi Li, Lei Wang, Zhenggang Zhang, Dunyue Lu, Mei Lu, M. Chopp   +6 more
semanticscholar   +1 more source