Results 11 to 20 of about 13,927 (161)

A variable CD3⁺ T-cell frequency in peripheral blood lymphocytes associated with type 1 diabetes mellitus development in the LEW.1AR1-iddm rat. [PDF]

PLoS ONE, 2013
PURPOSE: The LEW.1AR1-iddm rat is an animal model of human type 1 diabetes mellitus (T1DM), which arose through a spontaneous mutation within the MHC-congenic inbred strain LEW.1AR1 (RT1(r²)).
Tanja Arndt, Anne Jörns, Heike Weiss, Markus Tiedge, Hans-Jürgen Hedrich, Sigurd Lenzen, Dirk Wedekind   +6 more
doaj   +1 more source

Genetic background specific hypoxia resistance in rat is correlated with balanced activation of a cross-chromosomal genetic network centering on physiological homeostasis

Frontiers in Genetics, 2012
Genetic background of an individual can drastically influence an organism’s response upon environmental stress and pathological stimulus. Previous studies in inbred rats showed that compared to Brown Norway (BN), Dahl salt-sensitive (SS) rat exerts ...
Lei eMao
doaj   +1 more source

Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundCell damage, tissue and vascular injury are associated with the exposure and release of intracellular components such as RNA, which promote inflammatory reactions and thrombosis. Based on the counteracting anti‐inflammatory and cardioprotective
Eike Kleinert, Martin C. Langenmayer, Bruno Reichart, Jana Kindermann, Barbara Griemert, Andreas Blutke, Kerstin Troidl, Tanja Mayr, Tobias Grantzow, Fatih Noyan, Jan‐Michael Abicht, Silvia Fischer, Klaus T. Preissner, Ruediger Wanke, Elisabeth Deindl, Sonja Guethoff   +15 more
doaj   +1 more source

Mechanisms altering airway smooth muscle cell Ca(2+) homeostasis in two asthma models [PDF]

, 2008
Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In particular, alterations of ASMC contractility seem to be of crucial importance. The
Kellner, Julia, Tantzscher, Juliane, Edelmann, Martin, Bergner, Albrecht, Oelmez, Hamza, Huber, Rudolf M., Fischer, Rainald   +6 more
core   +1 more source

Von Willebrand Factor Gene Variants Associate with Herpes simplex Encephalitis.

PLoS ONE, 2016
Herpes simplex encephalitis (HSE) is a rare complication of Herpes simplex virus type-1 infection. It results in severe parenchymal damage in the brain.
Nada Abdelmagid, Biborka Bereczky-Veress, Santosh Atanur, Alena Musilová, Václav Zídek, Laura Saba, Andreas Warnecke, Mohsen Khademi, Marie Studahl, Elisabeth Aurelius, Anders Hjalmarsson, Ana Garcia-Diaz, Cécile V Denis, Tomas Bergström, Birgit Sköldenberg, Ingrid Kockum, Timothy Aitman, Norbert Hübner, Tomas Olsson, Michal Pravenec, Margarita Diez   +20 more
doaj   +1 more source

A Genetically Heterogeneous Rat Model with Divergent Mitochondrial Genomes [PDF]

, 2023
We generated a genetically heterogenous rat model by a 4-way cross strategy using 4 inbred strains (Brown Norway [BN], Fischer 344 [F344], Lewis [LEW], and Wistar Kyoto [KY]) to provide investigators with a highly genetically diverse rat model from ...
Hoang Van M Nguyen, Vandiver, Amy, Hannah Yarbrough, Arlan Richardson, Nguyen, Hoang, Yarbrough, Hannah, Logan, Sreemathi, Sathiaseelan, Roshini, Anthony Masingale, Roshini Sathiaseelan, Richardson, Arlan, Stout, Michael, Selvarani, Ramasamy, Sreemathi Logan, Wanagat, Jonathan, Ramasamy Selvarani, Hord, Norman, Miller, Benjamin, Amy R Vandiver, Roman F Wolf, Benjamin F Miller, Rojina Ranjit, Michael B Stout, Jonathan Wanagat, Steven N Austad, Ranjit, Rojina, Bumsoo Ahn, Norman G Hord, Austad, Steven, Ahn, Bumsoo, Wolf, Roman, Masingale, Anthony   +31 more
core   +1 more source

Angiotensin I-converting enzyme gene polymorphism influences chronic hypertensive response in the rat Goldblatt model [PDF]

, 2002
Background and objective In humans, the insertion/ deletion polymorphism in the anglotensin (Ang) I converting enzyme (ACE) gene significantly determines ACE activity.
Lavandero, Sergio, Piddo, Ana M., Ocaranza Jeraldino, María Paz, Jalil Milad, Jorge Emilio, Faundez, Perla   +4 more
core   +2 more sources

Methacholine-induced airway reactivity of inbred rats

, 1986
Dose-response curves to inhaled aerosolized methacholine chloride (MCh) were obtained in anesthetized spontaneously breathing rats. Thirty rats (10/strain), randomly selected from highly inbred ACI, Lewis (L), and Brown Norway (BN) strains and 40 rats ...
J. G. Martin, G. DiMaria, C. G. Wang, R. D. Guttmann, J. H. Bates   +4 more
core   +1 more source

Screening and Analysis of Microsatellite Genetic Markers in Commonly Used Inbred Rat Strains

Shiyan dongwu yu bijiao yixue
ObjectiveTo screen a set of short tandem repeat (STR) markers covering rat chromosomes 1-20 and the X chromosome, with 2-4 markers on each chromosome, and establish a dedicated marker panel for genetic contamination detection and strain identification of
TANG Jianping, ZHAO Liya, ZHAO Ying
doaj   +1 more source

Cutaneous Cyst Number and Genotype of 215 (LE/Stm x BN) F2 Rats

, 2019
There is evidence that the development of multiple cutaneous cysts (benign skin tumors) is heritable . Using inbred BN rats susceptible to chemically induced cutaneous cyst development and resistant LE/Stm rats we were able to establish a new animal ...
Kindler-Roehrborn, A (via Mendeley Data)
core   +1 more source