Results 11 to 20 of about 3,279 (105)

Mitochondrial Haplotype Shapes the Trajectory of Ovarian Aging in Genetically Heterogeneous Rats. [PDF]

Aging Cell
Using genetically heterogeneous rats carrying divergent mitochondrial haplotypes on a randomized nuclear background, we show that mtDNA variation modifies the rate of ovarian aging. OKC‐HETW ovaries showed bioenergetic deficits, reduced mtDNA copy number, and impaired TFAM–mtDNA binding by 4 months of age, with early fibrosis and immune infiltration ...
Biswas S, Nguyen HVM, Converse A, Matsuzaki S, Kinter MT, Humphries KM, Freeman WM, Ocañas SR, Richardson A, Duncan FE, Lewis TL, Stout MB.   +11 more
europepmc   +2 more sources

The evidence for old age motor neuron death: A scoping review. [PDF]

Physiol Rep
We systematically evaluated the extant literature on age‐related motor neuron (MN) death in aging, focusing on studies directly assessing MNs. We show that in the spinal cord and brainstem, there is robust evidence for MN loss, particularly in the human spinal cord. In rats, MN loss was readily observed across a variety of labelling methods and regions,
Cheung SW, Fogarty MJ.
europepmc   +2 more sources

Genetic background specific hypoxia resistance in rat is correlated with balanced activation of a cross-chromosomal genetic network centering on physiological homeostasis

Frontiers in Genetics, 2012
Genetic background of an individual can drastically influence an organism’s response upon environmental stress and pathological stimulus. Previous studies in inbred rats showed that compared to Brown Norway (BN), Dahl salt-sensitive (SS) rat exerts ...
Lei eMao
doaj   +1 more source

Nociception and conditioned fear in rats: strains matter.

PLoS ONE, 2013
When using rats in pain research, strain-related differences in outcomes of tests for pain and nociception are acknowledged. However, very little is known about the specific characteristics of these strain differences. In this study four phylogenetically
Manon W H Schaap, Hugo van Oostrom, Arie Doornenbal, José van 't Klooster, Annemarie M Baars, Saskia S Arndt, Ludo J Hellebrekers   +6 more
doaj   +1 more source

Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundCell damage, tissue and vascular injury are associated with the exposure and release of intracellular components such as RNA, which promote inflammatory reactions and thrombosis. Based on the counteracting anti‐inflammatory and cardioprotective
Eike Kleinert, Martin C. Langenmayer, Bruno Reichart, Jana Kindermann, Barbara Griemert, Andreas Blutke, Kerstin Troidl, Tanja Mayr, Tobias Grantzow, Fatih Noyan, Jan‐Michael Abicht, Silvia Fischer, Klaus T. Preissner, Ruediger Wanke, Elisabeth Deindl, Sonja Guethoff   +15 more
doaj   +1 more source

Von Willebrand Factor Gene Variants Associate with Herpes simplex Encephalitis.

PLoS ONE, 2016
Herpes simplex encephalitis (HSE) is a rare complication of Herpes simplex virus type-1 infection. It results in severe parenchymal damage in the brain.
Nada Abdelmagid, Biborka Bereczky-Veress, Santosh Atanur, Alena Musilová, Václav Zídek, Laura Saba, Andreas Warnecke, Mohsen Khademi, Marie Studahl, Elisabeth Aurelius, Anders Hjalmarsson, Ana Garcia-Diaz, Cécile V Denis, Tomas Bergström, Birgit Sköldenberg, Ingrid Kockum, Timothy Aitman, Norbert Hübner, Tomas Olsson, Michal Pravenec, Margarita Diez   +20 more
doaj   +1 more source

Screening and Analysis of Microsatellite Genetic Markers in Commonly Used Inbred Rat Strains

Shiyan dongwu yu bijiao yixue
ObjectiveTo screen a set of short tandem repeat (STR) markers covering rat chromosomes 1-20 and the X chromosome, with 2-4 markers on each chromosome, and establish a dedicated marker panel for genetic contamination detection and strain identification of
TANG Jianping, ZHAO Liya, ZHAO Ying
doaj   +1 more source

A Gamma Ray–Induced Dwarf and Early Mutant of Brassica juncea With Favourable Traits for Developing High‐Yielding, Dwarf/Semi‐Dwarf Genotypes

Plant Breeding, EarlyView.
ABSTRACT Introduction of dwarfism to cereals has set a new paradigm in crop improvement programmes. To date, very little progress has been made in the development of high‐yielding dwarf/semi‐dwarf genotypes in oilseed Brassica. Previous attempts using induced mutagenesis employed in the induction of dwarfism in Brassica crops yielded limited success ...
Shankar K. Bhujbal, Archana N. Rai, Sanjay J. Jambhulkar, Archana Joshi‐Saha   +3 more
wiley   +1 more source

Drone‐based phenotyping of maize for multiple disease resistance and yield in breeding field trials

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Improving selection for multiple disease resistance (MDR) and yield in maize (Zea mays L.) requires high‐throughput, objective phenotyping tools, particularly under field conditions where several foliar diseases co‐occur. We evaluated drone‐based multispectral vegetation indices (VIs) for predicting resistance to northern leaf blight (NLB ...
Danilo E. Moreta, Nina Blahut, Nicholas Kaczmar, Judith M. Kolkman, Gary Bergstrom, Margaret Smith, Michael A. Gore, Rebecca Nelson   +7 more
wiley   +1 more source

Smartphone‐based proximal sensing as an accessible platform for improved physiological phenotyping

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract We tested whether smartphone‐based sensing could deliver accurate physiological traits in an accessible and low‐cost platform. A smartphone, carried by someone walking through a field, was used to generate a high‐resolution time series of images for 10 genotypes of cowpea (Vigna unguiculata L. Walp.).
Isaac K. Uyehara, Jonathan M. Berlingeri, Sassoum Lo, Margaret Riggs, Riya Desai, Kyle T. Rizzo, J. Mason Earles, Christine H. Diepenbrock, Brian N. Bailey   +8 more
wiley   +1 more source