Results 11 to 20 of about 3,265 (105)

Hi-C sequencing data from frontal cortex of laboratory rats. [PDF]

Sci Data
The three-dimensional structure of chromosomes is integral to nuclear organization and influences processes such as DNA replication, repair, and gene expression.
Kim P, Ward RR, Sharp BM, Williams RW, Chen H.   +4 more
europepmc   +2 more sources

Phenotypic and gene expression differences between DA, BN and WOKW rats. [PDF]

PLoS ONE, 2012
BACKGROUND: Because inbred rat strains are widely used as laboratory models, knowledge of phenotypic and genetic variations between strains will be useful to obtain insight into the relationship between different strains.
Jörn Lange, Thomas Barz, Axel Ekkernkamp, Barbara Wilke, Ingrid Klöting, Niels Follak   +5 more
doaj   +1 more source

Lower developmental potential of rat zygotes produced by ooplasmic injection of testicular spermatozoa versus cauda epididymal spermatozoa. [PDF]

J Reprod Dev
Intracytoplasmic sperm injection (ICSI) is clinically used to treat obstructive/nonobstructive azoospermia. This study compared the efficacy of ICSI with cauda epididymal and testicular sperm in Wistar (WI) and Brown-Norway (BN) rats.
Ide M, Saito I, Sanbo M, Kanatsu-Shinohara M, Shinohara T, Hirabayashi M, Hochi S.   +6 more
europepmc   +2 more sources

Genetic etiology of renal agenesis: fine mapping of Renag1 and identification of Kit as the candidate functional gene. [PDF]

PLoS ONE, 2015
Congenital anomalies of the kidney and urogenital tract (CAKUT) occur in approximately 0.5% of live births and represent the most frequent cause of end-stage renal disease in neonates and children. The genetic basis of CAKUT is not well defined.
Nyssa Becker Samanas, Tessa W Commers, Kirsten L Dennison, Quincy Eckert Harenda, Scott G Kurz, Cynthia M Lachel, Kristen Leland Wavrin, Michael Bowler, Isaac J Nijman, Victor Guryev, Edwin Cuppen, Norbert Hubner, Ruth Sullivan, Chad M Vezina, James D Shull   +14 more
doaj   +1 more source

A variable CD3⁺ T-cell frequency in peripheral blood lymphocytes associated with type 1 diabetes mellitus development in the LEW.1AR1-iddm rat. [PDF]

PLoS ONE, 2013
PURPOSE: The LEW.1AR1-iddm rat is an animal model of human type 1 diabetes mellitus (T1DM), which arose through a spontaneous mutation within the MHC-congenic inbred strain LEW.1AR1 (RT1(r²)).
Tanja Arndt, Anne Jörns, Heike Weiss, Markus Tiedge, Hans-Jürgen Hedrich, Sigurd Lenzen, Dirk Wedekind   +6 more
doaj   +1 more source

MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes

BMC Medical Genomics, 2009
Background MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis.
Fernandez Christina, Camps Carme, Barrett Amy, Kaisaki Pamela J, Wills Quin F, Taylor Jennifer M, Lockstone Helen E, Herrera Blanca M, Ragoussis Jiannis, Gauguier Dominique, McCarthy Mark I, Lindgren Cecilia M   +11 more
doaj   +1 more source

Genetic control of differential acetylation in diabetic rats.

PLoS ONE, 2014
Post-translational protein modifications such as acetylation have significant regulatory roles in metabolic processes, but their relationship to both variation in gene expression and DNA sequence is unclear. We address this question in the Goto-Kakizaki (
Pamela J Kaisaki, Georg W Otto, Joanna F McGouran, Amine Toubal, Karène Argoud, Helen Waller-Evans, Clare Finlay, Sophie Caldérari, Marie-Thérèse Bihoreau, Benedikt M Kessler, Dominique Gauguier, Richard Mott   +11 more
doaj   +1 more source

Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression

G3: Genes, Genomes, Genetics, 2016
To test the impact of genetic heterogeneity on cis- and trans-mediated mechanisms of gene expression regulation, we profiled the transcriptome of adipose tissue in 20 inbred congenic strains derived from diabetic Goto–Kakizaki (GK) rats and Brown–Norway (
Pamela J. Kaisaki, Georg W. Otto, Karène Argoud, Stephan C. Collins, Robert H. Wallis, Steven P. Wilder, Anthony C. Y. Yau, Christophe Hue, Sophie Calderari, Marie-Thérèse Bihoreau, Jean-Baptiste Cazier, Richard Mott, Dominique Gauguier   +12 more
doaj   +1 more source

Genetic background specific hypoxia resistance in rat is correlated with balanced activation of a cross-chromosomal genetic network centering on physiological homeostasis

Frontiers in Genetics, 2012
Genetic background of an individual can drastically influence an organism’s response upon environmental stress and pathological stimulus. Previous studies in inbred rats showed that compared to Brown Norway (BN), Dahl salt-sensitive (SS) rat exerts ...
Lei eMao
doaj   +1 more source

Nociception and conditioned fear in rats: strains matter.

PLoS ONE, 2013
When using rats in pain research, strain-related differences in outcomes of tests for pain and nociception are acknowledged. However, very little is known about the specific characteristics of these strain differences. In this study four phylogenetically
Manon W H Schaap, Hugo van Oostrom, Arie Doornenbal, José van 't Klooster, Annemarie M Baars, Saskia S Arndt, Ludo J Hellebrekers   +6 more
doaj   +1 more source