Results 21 to 30 of about 5,868 (132)

Identification of a Novel Gene for Diabetic Traits in Rats, Mice, and Humans [PDF]

, 2014
The genetic basis of type 2 diabetes remains incompletely defined despite the use of multiple genetic strategies. Multiparental populations such as heterogeneous stocks (HS) facilitate gene discovery by allowing fine mapping to only a few megabases ...
Andrae, Jaime Wendt, Galione, Antony, He, Hong, Hessner, Martin, Hoffmann, Raymond G., Holl, Katie, Jacob, Howard, Jia, Shuang, Kaldunski, Mary, Li, Shun-Hua, Meigs, James, Parrington, John, Ruas da Silva, Margarida, Simpson, Pippa, Solberg Woods, Leah C., Stoddard, Alex, Tsaih, Shirng-Wern, Tschannen, Michael, Wiederhold, Andrew   +18 more
core   +1 more source

Cerebellar output controls generalized spike-and-wave discharge occurence [PDF]

, 2015
© 2015 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (CC BY-NC-ND 4.0)
Alva, Parimala, Davey, N., De Zeeuw, Chris I., Eelkman Rooda, Oscar, Hoebeek, Freek E., Karapatis, Athanasios, Kros, Lieke, Negrello, Mario, Serdijn, Wouter, Spanke, Jochen, Steuber, Volker, Strydis, Christos, Tolner, Else, van den Maagdenberg, Arn, van Dongen, Marijn, Winkelman, Beerend   +15 more
core   +11 more sources

Mechanisms altering airway smooth muscle cell Ca(2+) homeostasis in two asthma models [PDF]

, 2008
Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In particular, alterations of ASMC contractility seem to be of crucial importance. The
Bergner, Albrecht, Edelmann, Martin, Fischer, Rainald, Huber, Rudolf M., Kellner, Julia, Oelmez, Hamza, Tantzscher, Juliane   +6 more
core   +1 more source

Applying refinement to the use of mice and rats in rheumatoid arthritis research [PDF]

, 2015
Rheumatoid arthritis (RA) is a painful, chronic disorder and there is currently an unmet need for effective therapies that will benefit a wide range of patients. The research and development process for therapies and treatments currently involves in vivo
A Dinda, A Julià, A Livingston, AL Whittaker, AM Pulichino, B Bolon, BN Gaskill, BN Gaskill, C Kilkenny, C Kilkenny, CA Christianson, CL Karp, CM Sherwin, D Baker, D Pretzel, D Volker, DB Bas, DD Brand, DJ Langford, DS McQueen, E Hutchinson, Elliot Lilley, European Commission, FC Colpaert, FC Colpaert, FC Colpaert, G Kollias, GK Ford, H Smolian, H Yoshitomi, HB Patel, HB Worp van der, HE Krug, J Havey, JL Hurst, JR Earl, K Gouveia, K Ren, Katherine Knight, KM Kokolus, KR Jacobsen, KSP Abelson, L Bevaart, L Carbone, L Moja, LF Mikkelsen, LM Khachigian, M Bara, M Bianchi, M Neidhart, MH Ullman-Culleré, Michael Seed, Michael Wilkinson, MJ Gentle, MJ Molina-Cimadevila, ML Andersen, MW Festing, N Maicas, N Malik, National Research Council, NJ Osborne, P Hawkins, P Honoré, P Loo Van, P McGonigle, Paul Garside, Penny Hawkins, PH Wooley, R McCarthy, Rachel Armstrong, Richard O. Williams, RS Ulrich, S Ribel-Madsen, SA Tischkau, SC Chan, SG Sotocinal, SG Trivedi, SH Richter, T Montero-Melendez, Tania Boden, TL Vincent, V Baumans, V Marashi, V Strand, W Paska, Y Jasemian, Y Peck   +86 more
core   +2 more sources

Organ Specificity and Commonality of Epigenetic Aging in Low‐ and High‐Running Capacity Rats

Aging Cell, EarlyView.
Cardiorespiratory fitness (CRF) is not associated with epigenetic clocks, including newly developed ones. On the other hand, CRF is associated with global methylation profiles and promoter methylation in organ‐specific and organ‐common manner. ABSTRACT Epigenetic drift, which is gradual age‐related changes in DNA methylation patterns, plays a ...
Takuji Kawamura, Csaba Kerepesi, Juliet Polok Sarkar, Ferenc Torma, Zoltan Bori, Lei Zhou, Peter Bakonyi, Attila Kolonics, Laszlo Balogh, Mitsuru Higuchi, Vivien Pillár, Karolina Pircs, Lauren Gerard Koch, Steven Loyal Britton, Erika Koltai, Zsolt Radak   +15 more
wiley   +1 more source

Less Invasive Surfactant Administration Versus Intubate‐Surfactant‐Extubate: Associated With Reduced Mechanical Ventilation in Extremely Preterm Infants

Acta Paediatrica, EarlyView.
ABSTRACT Aim To compare less invasive surfactant administration (LISA) and intubation‐surfactant‐extubation (INSURE) in infants born before 28 weeks gestational age (GA) by the need for mechanical ventilation (MV). Methods LISA was introduced in 2017 in our unit without formal prior LISA‐specific training as an equal alternative to INSURE.
C. Heiring, S. S. Hedegaard, E. M. Carlsen, R. Kristensen, N. Breindahl, C. Schmidt, E. T. Bay, I. M. L. Nyegaard, T. B. Henriksen, L. Aunsholt   +9 more
wiley   +1 more source

Heterotopic heart transplantation in the rat receiving FK-506 alone or with cyclosporine. [PDF]

, 1987
In rats, FK significantly prolonged heterotopic heart graft survival over a wide dose range when given for 2 weeks starting on the day of the operation.
Chapman, F, Lai, HS, Lee, PH, Makowka, L, Murase, N, Nalesnik, MA, Starzl, TE, Todo, S   +7 more
core  

Topological Analysis of Metabolic Networks Integrating Co-Segregating Transcriptomes and Metabolomes in Type 2 Diabetic Rat Congenic Series [PDF]

, 2016
Background: The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus is caused by complex organ-specific cellular mechanisms contributing to impaired insulin secretion and insulin resistance.
Argoud, K, Ayala, R, Calderari, S, Cazier, JB, Collins, S, Domange, C, Dumas, ME, Gauguier, D, Gu, Q, Holmes, E, Hue, C, Lindon, JC, Mitchell, S, Navratil, V, Nicholson, JK, Otto, GW, Rodriguez Martinez, A, Suárez-Zamorano, N, Wallis, R, Wang, Y, Wilder, S   +20 more
core   +5 more sources

Real‐World Therapeutic Hypothermia for Neonatal HIE: Neurodevelopmental Outcomes and Predictors

Acta Paediatrica, EarlyView.
ABSTRACT Aim This study assessed neurodevelopmental outcomes in neonates with hypoxic‐ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) outside randomised controlled trials (RCTs). It also aimed to identify predictors of outcomes and evaluate TH practices across centres.
Luca Bedetti, Licia Lugli, Isotta Guidotti, Maria Federica Roversi, Elisa Della Casa Muttini, Marisa Pugliese, Natascia Bertoncelli, Eugenio Spaggiari, Alessandra Todeschini, Gina Ancora, Sara Grandi, Giancarlo Gargano, Claudio Gallo, Mario Motta, Piero Catenazzi, Luigi Tommaso Corvaglia, Vittoria Paoletti, Agostina Solinas, Elisa Ballardini, Serafina Perrone, Sabrina Moretti, Marcello Stella, Alberto Berardi, Fabrizio Ferrari   +23 more
wiley   +1 more source

Adolescent D-amphetamine treatment in a rodent model of ADHD: pro-cognitive effects during adolescence and cocaine abuse risk during adulthood [PDF]

, 2015
Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk.
Baskin, Britahny M., Dwoskin, Linda P., Jeon, Sae-Mi, Jordan, Chloe J., Kantak, Kathleen M., Taylor, Danielle M.   +5 more
core   +1 more source