Genome-Wide Fine-Mapping Of Diabetic Traits [PDF]
, 2013 Type 2 diabetes results from both genes and the environment. Mapping genetic loci in animal models can help identify genes that are involved in type 2 diabetes to better understand the disease.
Baur, Brittany
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High-resolution genome screen for bone mineral density in heterogeneous stock rat [PDF]
, 2014 We previously demonstrated that skeletal mass, structure, and biomechanical properties vary considerably in heterogeneous stock (HS) rat strains. In addition, we observed strong heritability for several of these skeletal phenotypes in the HS rat model ...
Alam, Imranul +15 more
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FEBS Open Bio, Volume 15, Issue 1, Page 69-80, January 2025.Cytokine levels in adult valproic acid (VPA)‐induced mouse (C57BL6) model of autism has been investigated and found to be altered. We show that bilateral transcutaneous auricular vagus nerve stimulation (tVNS) altered the inflammatory response and increased brain NLPR3 levels.
Hale Gök Dağıdır +7 more
wiley +1 more source
Comparative analysis of methods for gene transcription profiling data derived from different microarray technologies in rat and mouse models of diabetes [PDF]
, 2009 BACKGROUND: Microarray technologies are widely used to quantify the abundance of transcripts corresponding to thousands of genes. To maximise the robustness of transcriptome results, we have tested the performance and reproducibility of rat and mouse ...
Anita Salhan +6 more
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Journal of Neurochemistry, Volume 169, Issue 1, January 2025.Aim of this study is to investigate drugs that modulate GGGGCC repeat aggregation, a key feature in neurodegenerative diseases such as ALS and FTD. The research emphasizes the role of the C9orf72 gene, which is implicated in these disorders, and focuses on G‐quadruplex (G4) DNA structures formed by these repeats.
Andrea Patrizia Falanga +7 more
wiley +1 more source
Developmental constraint underlies the replicated evolution of grass awns
New Phytologist, Volume 245, Issue 2, Page 835-848, January 2025.Summary Replicated trait evolution can provide insights into the mechanisms underlying the evolution of biodiversity. One example of replicated evolution is the awn, an organ elaboration in grass inflorescences. Awns are likely homologous to leaf blades.
Erin Patterson +6 more
wiley +1 more source
Creation of a Computational Pipeline to Extract Genes from Quantitative Trait Loci for Diabetes and Obesity [PDF]
, 2015 Type 2 Diabetes is a disease of relative insulin deficiency resulting from a combination of insulin resistance and decreased beta-cell function. Over the past several years, over 60 genes have been identified for Type 2 Diabetes in human genome-wide ...
Fox, Joseph
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Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats [PDF]
, 2017 This protocol describes the use of in vitro television microscopy to evaluate vascular function in isolated cerebral resistance arteries (and other vessels), and describes techniques for evaluating tissue perfusion using Laser Doppler Flowmetry (LDF) and
Allen, L. Adrienne +6 more
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Efficient single nucleotide polymorphism discovery in laboratory rat strains using wild rat-derived SNP candidates [PDF]
, 2005 BACKGROUND: The laboratory rat (Rattus norvegicus) is an important model for studying many aspects of human health and disease. Detailed knowledge on genetic variation between strains is important from a biomedical, particularly pharmacogenetic point of ...
Cuppen, Edwin +5 more
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Positional identification of variants of Adamts16 linked to inherited hypertension [PDF]
, 2017 A previously reported blood pressure (BP) quantitative trait locus on rat Chromosome 1 was isolated in a short congenic segment spanning 804.6 kb. The 804.6 kb region contained only two genes, LOC306664 and LOC306665.
Achinike, Ovokeraye H. +25 more
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