Amino Acid Metabolism and Immune Dysfunction in Urea Cycle Disorders: T and B Cell Perspectives
Journal of Inherited Metabolic Disease, Volume 48, Issue 2, March 2025.ABSTRACT Urea cycle disorders (UCDs) are a group of genetic metabolic conditions characterized by enzyme deficiencies responsible for detoxifying ammonia. Hyperammonemia, the accumulation of intermediate metabolites, and a deficiency of essential amino acids—due to a protein‐restrictive diet and the use of ammonia scavengers—can increase the risk of ...
Betul Gemici Karaaslan +11 more
wiley +1 more source
Topological Analysis of Metabolic Networks Integrating Co-Segregating Transcriptomes and Metabolomes in Type 2 Diabetic Rat Congenic Series [PDF]
, 2016 Background: The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus is caused by complex organ-specific cellular mechanisms contributing to impaired insulin secretion and insulin resistance.
Argoud, K +20 more
core +5 more sources
Genomes and phenomes of a population of outbred rats and its progenitors [PDF]
, 2014 Finding genetic variants that contribute to phenotypic variation is one of the main challenges of modern genetics. We used an outbred population of rats (Heterogeneous Stock, HS) in a combined sequence-based and genetic mapping analysis to identify ...
+5 more
core +3 more sources
Genome-Wide Fine-Mapping Of Diabetic Traits [PDF]
, 2013 Type 2 diabetes results from both genes and the environment. Mapping genetic loci in animal models can help identify genes that are involved in type 2 diabetes to better understand the disease.
Baur, Brittany
core +1 more source
Genetic Influences on Brain Gene Expression in Rats Selected for Tameness and Aggression
, 2014 Inter-individual differences in many behaviors are partly due to genetic differences, but the identification of the genes and variants that influence behavior remains challenging.
Alexander Cagan +16 more
core +1 more source
Reduced Levels of mGlu2 Receptors within the Prelimbic Cortex Are Not Associated with Elevated Glutamate Transmission or High Alcohol Drinking [PDF]
, 2017 Background A Grm2 cys407* stop codon mutation, which results in a loss of the metabotropic glutamate 2 (mGlu2) receptor protein, was identified as being associated with high alcohol drinking by alcohol-preferring (P) rats.
Bell, Richard L. +5 more
core +1 more source
COMPLEMENT FACTOR B IS A DETERMINANT OF BOTH METABOLIC AND CARDIOVASCULAR FEATURES OF METABOLIC SYNDROME [PDF]
, 2017 CFB (complement factor B) is elevated in adipose tissue and serum from patients with type 2 diabetes mellitus and cardiovascular disease, but the causal relationship to disease pathogenesis is unclear.
Aitman, Timothy J. +15 more
core +2 more sources
Adolescent D-amphetamine treatment in a rodent model of ADHD: pro-cognitive effects in adolescence without an impact on cocaine cue reactivity in adulthood [PDF]
, 2016 Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk.
Dwoskin, Linda P. +3 more
core +1 more source
Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. [PDF]
, 2020 Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the ...
Carrette, Lieselot LG +7 more
core
High-resolution genome screen for bone mineral density in heterogeneous stock rat [PDF]
, 2014 We previously demonstrated that skeletal mass, structure, and biomechanical properties vary considerably in heterogeneous stock (HS) rat strains. In addition, we observed strong heritability for several of these skeletal phenotypes in the HS rat model ...
Alam, Imranul +15 more
core +1 more source