Results 51 to 60 of about 14,911 (165)
Applying refinement to the use of mice and rats in rheumatoid arthritis research [PDF]
, 2015 Rheumatoid arthritis (RA) is a painful, chronic disorder and there is currently an unmet need for effective therapies that will benefit a wide range of patients. The research and development process for therapies and treatments currently involves in vivo A Dinda, A Julià, A Livingston, AL Whittaker, AM Pulichino, B Bolon, BN Gaskill, BN Gaskill, C Kilkenny, C Kilkenny, CA Christianson, CL Karp, CM Sherwin, D Baker, D Pretzel, D Volker, DB Bas, DD Brand, DJ Langford, DS McQueen, E Hutchinson, Elliot Lilley, European Commission, FC Colpaert, FC Colpaert, FC Colpaert, G Kollias, GK Ford, H Smolian, H Yoshitomi, HB Patel, HB Worp van der, HE Krug, J Havey, JL Hurst, JR Earl, K Gouveia, K Ren, Katherine Knight, KM Kokolus, KR Jacobsen, KSP Abelson, L Bevaart, L Carbone, L Moja, LF Mikkelsen, LM Khachigian, M Bara, M Bianchi, M Neidhart, MH Ullman-Culleré, Michael Seed, Michael Wilkinson, MJ Gentle, MJ Molina-Cimadevila, ML Andersen, MW Festing, N Maicas, N Malik, National Research Council, NJ Osborne, P Hawkins, P Honoré, P Loo Van, P McGonigle, Paul Garside, Penny Hawkins, PH Wooley, R McCarthy, Rachel Armstrong, Richard O. Williams, RS Ulrich, S Ribel-Madsen, SA Tischkau, SC Chan, SG Sotocinal, SG Trivedi, SH Richter, T Montero-Melendez, Tania Boden, TL Vincent, V Baumans, V Marashi, V Strand, W Paska, Y Jasemian, Y Peck +86 morecore +2 more sourcesAmino Acid Metabolism and Immune Dysfunction in Urea Cycle Disorders: T and B Cell Perspectives
Journal of Inherited Metabolic Disease, Volume 48, Issue 2, March 2025.ABSTRACT
Urea cycle disorders (UCDs) are a group of genetic metabolic conditions characterized by enzyme deficiencies responsible for detoxifying ammonia. Hyperammonemia, the accumulation of intermediate metabolites, and a deficiency of essential amino acids—due to a protein‐restrictive diet and the use of ammonia scavengers—can increase the risk of ...Betul Gemici Karaaslan, Ayca Kiykim, Nihan Burtecene, Meltem Gokden, Mehmet Serif Cansever, Duhan Hopurcuoglu, Gökçe Nuran Cengiz, Birol Topcu, Tanyel Zubarioğlu, Ertugrul Kiykim, Haluk Cokuğras, Ayse Cigdem Aktuglu Zeybek +11 morewiley +1 more sourcePositional identification of variants of Adamts16 linked to inherited hypertension [PDF]
, 2017 A previously reported blood pressure (BP) quantitative trait locus on rat Chromosome 1 was isolated in a short congenic segment spanning 804.6 kb. The 804.6 kb region contained only two genes, LOC306664 and LOC306665.Achinike, Ovokeraye H., Apte, Suneel S., Bouchard, Claude, Chakravarti, Aravinda, Coe, David, Cooper, Richard S., Ehret, Georg B., Farms, Phyllis, Frank, Bryan C., Ganesh, Santhi K., Garrett, Michael R., Gopalakrishnan, Kathirvel, Joe, Bina, Lee, Norman H., Luu, Truong V., Manickavasagam, Ezhilarasi, O'Connor, Ashley, Pérusse, Louis, Rankinen, Tuomo, Rao, Dabeeru C., Rapp, John P., Rice, Treva, Saad, Yasser, Toland, Edward J., Weder, Alan B., Yerga-Woolwine, Shane +25 morecore tVNS alters inflammatory response in adult VPA‐induced mouse model of autism: evidence for sexual dimorphism
FEBS Open Bio, Volume 15, Issue 1, Page 69-80, January 2025.Cytokine levels in adult valproic acid (VPA)‐induced mouse (C57BL6) model of autism has been investigated and found to be altered. We show that bilateral transcutaneous auricular vagus nerve stimulation (tVNS) altered the inflammatory response and increased brain NLPR3 levels.Hale Gök Dağıdır, Neslihan Bukan, Meltem Bahcelioglu, Ayşen Çalıkuşu, Ece Alim, Saadet Özen Dizakar, Elif Topa, Hayrunnisa Bolay +7 morewiley +1 more sourceNanostructural Modulation of G‐Quadruplex DNA in Neurodegeneration: Orotate Interaction Revealed Through Experimental and Computational Approaches
Journal of Neurochemistry, Volume 169, Issue 1, January 2025.Aim of this study is to investigate drugs that modulate GGGGCC repeat aggregation, a key feature in neurodegenerative diseases such as ALS and FTD. The research emphasizes the role of the C9orf72 gene, which is implicated in these disorders, and focuses on G‐quadruplex (G4) DNA structures formed by these repeats.Andrea Patrizia Falanga, Ilaria Piccialli, Francesca Greco, Stefano D'Errico, Maria Grazia Nolli, Nicola Borbone, Giorgia Oliviero, Giovanni N. Roviello +7 morewiley +1 more sourceGenetic Influences on Brain Gene Expression in Rats Selected for
Tameness and Aggression
, 2014 Inter-individual differences in many behaviors are partly due to genetic
differences, but the identification of the genes and variants that influence
behavior remains challenging.Alexander Cagan, Belyaev, Darvasi, Enrico Petretto, Frank W. Albert, François Besnier, Henrike O. Heyne, Irina Z. Plyusnina, Leonid Kruglyak, Lyudmila Trut, Maxime Rotival, Rimma Kozhemyakina, Ronald Nelson, Susann Lautenschläger, Svante Pääbo, Torsten Schöneberg, Örjan Carlborg +16 morecore +1 more sourceTopological Analysis of Metabolic Networks Integrating Co-Segregating Transcriptomes and Metabolomes in Type 2 Diabetic Rat Congenic Series [PDF]
, 2016 Background: The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus is caused by complex organ-specific cellular mechanisms contributing to impaired insulin secretion and insulin resistance.Argoud, K, Ayala, R, Calderari, S, Cazier, JB, Collins, S, Domange, C, Dumas, ME, Gauguier, D, Gu, Q, Holmes, E, Hue, C, Lindon, JC, Mitchell, S, Navratil, V, Nicholson, JK, Otto, GW, Rodriguez Martinez, A, Suárez-Zamorano, N, Wallis, R, Wang, Y, Wilder, S +20 morecore +5 more sourcesMolecular targets of alcohol action: translational research for pharmacotherapy development and screening. [PDF]
, 2011 Alcohol abuse and dependence are multifaceted disorders with neurobiological, psychological, and environmental components. Research on other complex neuropsychiatric diseases suggests that genetically influenced intermediate characteristics affect the ...Addolorato, Alexander-Kaufman, Alte, American Psychiatric Association, Anni, Anton, Anton, Anton, Arkin, Arlinde, Aschner, Atz, Barr, Beck, Beck, Belknap, Bell, Bell, Bell, Bemeur, Bendroth, Bennett, Bennett, Bergeson, Bertsch, Bhardwaj, Bhave, Bierut, Blalock, Blednov, Blizard, Borucki, Bosch-Morell, Brodin, Buck, Bueno, Bull, Butterworth, Butterworth, Caberlotto, Caspi, Chatterjee, Chester, Chi, Ciccocioppo, Cloninger, Colantuoni, Colombo, Colombo, Cotton, Cozzoli, Crabbe, Crabbe, Crabbe, Crabbe, Crabbe, Crabbe, Crabbe, Crabbe, D'Souza, Daniels, Davies, Davis, Deken, Demarest, Dev, Dick, Dick, Dick, Dick, Duranceaux, Dutta, Edenberg, Edenberg, Edenberg, Edenberg, Ehlers, Erblich, Eriksson, Eriksson, Etheridge, Evans, Fehr, Fehr, Flatscher-Bader, Foroud, Franke, Freeman, Freeman, Fukuda, Garbutt, Garbutt, Garner, Gelernter, Geschwind, Godefroy, Goldman, Golka, Gorini, Gottesman, Griffiths-Jones, Hariri, Haroutunian, Harper, Harper, Hashimoto, Hassan, Heilig, Heilig, Helander, Higuchi, Hillemacher, Hinckers, Hirano, Hock, Hodge, Hoffman, Hoiseth, Hollander, Hommer, Hood, Hu, Huntley, Husi, Iwamoto, Iwamoto, Jackson, Johnson, Johnson, Johnson, Jones, Kashem, Kashem, Kasinathan, Kaur, Kawahara, Kemming, Kendler, Kerns, Kim, Kimpel, Kissack, Koch, Konkimalla, Koob, Koob, Koob, Kril, Kril, Kurose, Landgraf, Lappalainen, Lavoie, Le, Lea, Lee, Leeman, Leggio, Leggio, Leggio, Leggio, Leggio, Lewohl, Lewohl, Li, Li, Litten, Liu, Liu, Liu, Lock, Loring, Lu, Ludvig, Luthar, Mackay, MacLaren, Maiya, Maiya, Mane, Mann, Marcotte, Mardones, Matsuda-Matsumoto, Matsumoto, Matsumoto, Maycox, Mayfield, Mayfield, Mayfield, McBride, McBride, McBride, McClearn, McClearn, Melo, Merikangas, Merikangas, Miller, Milner, Miranda, Mirin, Mirnics, Mirnics, Mirnics, Mitchell, Mochly-Rosen, Montoliu, Moore, Mor, Morin, Morozova, Mortazavi, Mulligan, Murphy, Murphy, Muth, Nagy, Nestler, Neuhold, Niemela, Noble, Norenberg, Obara, Okutsu, Papagiannakopoulos, Petkov, Pfefferbaum, Phillips, Pietrzykowski, Pongrac, Pragst, Purcell, Quintanilla, Rahman, Ramani, Ratti, Rausch, Reynaud, Rhodes, Richter, Rimondini, Risinger, Roberts, Rodd, Rodd, Rodgers, Rogers, Rounsaville, Saba, Saito, Saito, Sakai, Sathyan, Scheiffele, Schuckit, Schuckit, Schuckit, Schuckit, Schuckit, Schuckit, Shen, Sher, Slutske, Smith, Sokolov, Sommer, Spanagel, Spanagel, Staub, Stephens, Sullivan, Sung, Swift, Swift, Szumlinski, Szumlinski, Tabakoff, Tabakoff, Tabakoff, Tang, Tang, Taracha, Tarantino, Taxman, Thibault, Thiele, Tkachev, Tomita, Treadwell, Vergne, Vetulani, Volavka, Volkow, Wahlsten, Wall, Walter, Wand, Weinshenker, Whitfield, Williams, Winokur, Worst, Wu, Wurst, Wurst, Xu, Yao, Yoneyama, Zembutsu +309 morecore +1 more sourceCOMPLEMENT FACTOR B IS A DETERMINANT OF BOTH METABOLIC AND CARDIOVASCULAR FEATURES OF METABOLIC SYNDROME [PDF]
, 2017 CFB (complement factor B) is elevated in adipose tissue and serum from patients with type 2 diabetes mellitus and cardiovascular disease, but the causal relationship to disease pathogenesis is unclear.Aitman, Timothy J., Alfazema, Neza, Arends, Mark J., Barrier, Marjorie, Carter, Roderick N., Castro Dopico, Xaquin, Coan, Philip, Diaz, Ana Garcia, Jackson-Jones, Lucy, Marion de Proce, Sophie, Morton, Nicholas M., Moss, Julie, Moyon, Ben, Ross, David, Thomson, Adrian J W, Webster, Zoe +15 morecore +2 more sourcesAdult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice [PDF]
, 2013 Epidemiological evidence suggests that low levels of vitamin D may predispose people to develop depression and cognitive impairment. While rodent studies have demonstrated that prenatal vitamin D deficiency is associated with altered brain development ...Burne, Thomas H. J., Eyles, Darryl W., Groves, Natalie J., Kesby, James P., Mackay-Sim, Alan, McGrath, John J. +5 morecore +1 more source
