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Jan and mini‐Jan, a model system for potato functional genomics
Plant Biotechnology Journal, Volume 23, Issue 4, Page 1243-1256, April 2025.Summary
Potato (Solanum tuberosum) is the third‐most important food crop in the world. Although the potato genome has been fully sequenced, functional genomics research of potato lags behind that of other major food crops, largely due to the lack of a model experimental potato line.Haoyang Xin, Luke W. Strickland, John P. Hamilton, Jacob K. Trusky, Chao Fang, Nathaniel M. Butler, David S. Douches, C. Robin Buell, Jiming Jiang +8 morewiley +1 more sourcePositional identification of variants of Adamts16 linked to inherited hypertension [PDF]
, 2017 A previously reported blood pressure (BP) quantitative trait locus on rat Chromosome 1 was isolated in a short congenic segment spanning 804.6 kb. The 804.6 kb region contained only two genes, LOC306664 and LOC306665.Achinike, Ovokeraye H., Apte, Suneel S., Bouchard, Claude, Chakravarti, Aravinda, Coe, David, Cooper, Richard S., Ehret, Georg B., Farms, Phyllis, Frank, Bryan C., Ganesh, Santhi K., Garrett, Michael R., Gopalakrishnan, Kathirvel, Joe, Bina, Lee, Norman H., Luu, Truong V., Manickavasagam, Ezhilarasi, O'Connor, Ashley, Pérusse, Louis, Rankinen, Tuomo, Rao, Dabeeru C., Rapp, John P., Rice, Treva, Saad, Yasser, Toland, Edward J., Weder, Alan B., Yerga-Woolwine, Shane +25 morecore Genomes and phenomes of a population of outbred rats and its progenitors [PDF]
, 2014 Finding genetic variants that contribute to phenotypic variation is one of the main challenges of modern genetics. We used an outbred population of rats (Heterogeneous Stock, HS) in a combined sequence-based and genetic mapping analysis to identify ..., Baud, Amelie, Flint, Jonathan, Guryev, Victor, Hummel, Oliver, Johannesson, Martina +5 morecore +3 more sourcesNociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. [PDF]
, 2020 Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the ...Carrette, Lieselot LG, de Guglielmo, Giordano, George, Olivier, Kallupi, Marsida, Kononoff, Jenni, Palmer, Abraham A, Schweitzer, Paul, Solberg Woods, Leah C +7 morecore Topological Analysis of Metabolic Networks Integrating Co-Segregating Transcriptomes and Metabolomes in Type 2 Diabetic Rat Congenic Series [PDF]
, 2016 Background: The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus is caused by complex organ-specific cellular mechanisms contributing to impaired insulin secretion and insulin resistance.Argoud, K, Ayala, R, Calderari, S, Cazier, JB, Collins, S, Domange, C, Dumas, ME, Gauguier, D, Gu, Q, Holmes, E, Hue, C, Lindon, JC, Mitchell, S, Navratil, V, Nicholson, JK, Otto, GW, Rodriguez Martinez, A, Suárez-Zamorano, N, Wallis, R, Wang, Y, Wilder, S +20 morecore +6 more sourcesMolecular targets of alcohol action: translational research for pharmacotherapy development and screening. [PDF]
, 2011 Alcohol abuse and dependence are multifaceted disorders with neurobiological, psychological, and environmental components. Research on other complex neuropsychiatric diseases suggests that genetically influenced intermediate characteristics affect the ...Addolorato, Alexander-Kaufman, Alte, American Psychiatric Association, Anni, Anton, Anton, Anton, Arkin, Arlinde, Aschner, Atz, Barr, Beck, Beck, Belknap, Bell, Bell, Bell, Bemeur, Bendroth, Bennett, Bennett, Bergeson, Bertsch, Bhardwaj, Bhave, Bierut, Blalock, Blednov, Blizard, Borucki, Bosch-Morell, Brodin, Buck, Bueno, Bull, Butterworth, Butterworth, Caberlotto, Caspi, Chatterjee, Chester, Chi, Ciccocioppo, Cloninger, Colantuoni, Colombo, Colombo, Cotton, Cozzoli, Crabbe, Crabbe, Crabbe, Crabbe, Crabbe, Crabbe, Crabbe, Crabbe, D'Souza, Daniels, Davies, Davis, Deken, Demarest, Dev, Dick, Dick, Dick, Dick, Duranceaux, Dutta, Edenberg, Edenberg, Edenberg, Edenberg, Ehlers, Erblich, Eriksson, Eriksson, Etheridge, Evans, Fehr, Fehr, Flatscher-Bader, Foroud, Franke, Freeman, Freeman, Fukuda, Garbutt, Garbutt, Garner, Gelernter, Geschwind, Godefroy, Goldman, Golka, Gorini, Gottesman, Griffiths-Jones, Hariri, Haroutunian, Harper, Harper, Hashimoto, Hassan, Heilig, Heilig, Helander, Higuchi, Hillemacher, Hinckers, Hirano, Hock, Hodge, Hoffman, Hoiseth, Hollander, Hommer, Hood, Hu, Huntley, Husi, Iwamoto, Iwamoto, Jackson, Johnson, Johnson, Johnson, Jones, Kashem, Kashem, Kasinathan, Kaur, Kawahara, Kemming, Kendler, Kerns, Kim, Kimpel, Kissack, Koch, Konkimalla, Koob, Koob, Koob, Kril, Kril, Kurose, Landgraf, Lappalainen, Lavoie, Le, Lea, Lee, Leeman, Leggio, Leggio, Leggio, Leggio, Leggio, Lewohl, Lewohl, Li, Li, Litten, Liu, Liu, Liu, Lock, Loring, Lu, Ludvig, Luthar, Mackay, MacLaren, Maiya, Maiya, Mane, Mann, Marcotte, Mardones, Matsuda-Matsumoto, Matsumoto, Matsumoto, Maycox, Mayfield, Mayfield, Mayfield, McBride, McBride, McBride, McClearn, McClearn, Melo, Merikangas, Merikangas, Miller, Milner, Miranda, Mirin, Mirnics, Mirnics, Mirnics, Mitchell, Mochly-Rosen, Montoliu, Moore, Mor, Morin, Morozova, Mortazavi, Mulligan, Murphy, Murphy, Muth, Nagy, Nestler, Neuhold, Niemela, Noble, Norenberg, Obara, Okutsu, Papagiannakopoulos, Petkov, Pfefferbaum, Phillips, Pietrzykowski, Pongrac, Pragst, Purcell, Quintanilla, Rahman, Ramani, Ratti, Rausch, Reynaud, Rhodes, Richter, Rimondini, Risinger, Roberts, Rodd, Rodd, Rodgers, Rogers, Rounsaville, Saba, Saito, Saito, Sakai, Sathyan, Scheiffele, Schuckit, Schuckit, Schuckit, Schuckit, Schuckit, Schuckit, Shen, Sher, Slutske, Smith, Sokolov, Sommer, Spanagel, Spanagel, Staub, Stephens, Sullivan, Sung, Swift, Swift, Szumlinski, Szumlinski, Tabakoff, Tabakoff, Tabakoff, Tang, Tang, Taracha, Tarantino, Taxman, Thibault, Thiele, Tkachev, Tomita, Treadwell, Vergne, Vetulani, Volavka, Volkow, Wahlsten, Wall, Walter, Wand, Weinshenker, Whitfield, Williams, Winokur, Worst, Wu, Wurst, Wurst, Xu, Yao, Yoneyama, Zembutsu +309 morecore +1 more sourceGenetic Influences on Brain Gene Expression in Rats Selected for
Tameness and Aggression
, 2014 Inter-individual differences in many behaviors are partly due to genetic
differences, but the identification of the genes and variants that influence
behavior remains challenging.Alexander Cagan, Belyaev, Darvasi, Enrico Petretto, Frank W. Albert, François Besnier, Henrike O. Heyne, Irina Z. Plyusnina, Leonid Kruglyak, Lyudmila Trut, Maxime Rotival, Rimma Kozhemyakina, Ronald Nelson, Susann Lautenschläger, Svante Pääbo, Torsten Schöneberg, Örjan Carlborg +16 morecore +1 more sourceReduced Levels of mGlu2 Receptors within the Prelimbic Cortex Are Not Associated with Elevated Glutamate Transmission or High Alcohol Drinking [PDF]
, 2017 Background
A Grm2 cys407* stop codon mutation, which results in a loss of the metabotropic glutamate 2 (mGlu2) receptor protein, was identified as being associated with high alcohol drinking by alcohol-preferring (P) rats.Bell, Richard L., Ding, Zheng-Ming, Hauser, Sheketha R., Ingraham, Cynthia M., Lasek, Amy W., McBride, William J. +5 morecore +1 more sourceHigh-resolution genome screen for bone mineral density in heterogeneous stock rat [PDF]
, 2014 We previously demonstrated that skeletal mass, structure, and biomechanical properties vary considerably in heterogeneous stock (HS) rat strains. In addition, we observed strong heritability for several of these skeletal phenotypes in the HS rat model ...Alam, Imranul, Baud, Amelie, Blázquez, Gloria, Cañete, Toni, Dieze, Margarita, Díaz-Morán, Sira, Econs, Michael J., Fernández-Teruel, Alberto, Foroud, Tatiana, Johannesson, Martina, Koller, Daniel L., López-Aumatell, Regina, Martínez-Membrives, Esther, Olsson, Tomas, Stridh, Pernilla, Tobeña, Adolf +15 morecore +1 more source