Induction of donor-specific transplantation tolerance to skin and cardiac allografts using mixed chimerism in (A + B → A) in rats [PDF]
Mixed allogeneic chimerism (A + B → A) was induced in rats by reconstitution of lethally irradiated LEW recipients with a mixture of T-cell depleted (TCD) syngeneic and TCD allogeneic ACI bone marrow. Thirty-seven percent of animals repopulated as stable
Cai, X +4 more
core +1 more source
ABSTRACT Objective To examine associations between a 5‐min Apgar score < 7 and severe neonatal outcomes in very preterm (VPT) infants and how results are impacted by variations in assigning Apgar scores within an international context. Design Prospective observational population‐based cohort study.
Harald Ehrhardt +79 more
wiley +1 more source
Currently, the animals commonly used to establish animal models of benign airway stenosis (BAS) include mice, rats, pigs, dogs, rabbits, and ferrets. The establishment methods involve one or a combination of two methods such as mechanical injury, tracheal cautery, cuff overpressure intubation, laser injury, and endoscopic silver nitrate cauterization ...
Wusheng Zhang +6 more
wiley +1 more source
Emotional reactivity and cognitive performance in aversively motivated tasks: a comparison between four rat strains [PDF]
Background Cognitive function might be affected by the subjects' emotional reactivity. We assessed whether behavior in different tests of emotional reactivity is correlated with performance in aversively motivated learning tasks, using four strains of ...
van der Staay, F.J. +7 more
core +2 more sources
We identified a novel resistance allele, NLB18‐R, at the Htn1 locus. Using CRISPR‐Cas9, we replaced the susceptible allele (NLB18‐S) with NLB18‐R in an elite inbred. We stacked NLB18‐R and the resistance gene Ht1‐R. The resulting genome‐edited plants exhibited resistance to Setosphaeria turcica races 0, 1 and 23N.
Huirong Gao +20 more
wiley +1 more source
Pharmacogenetic interaction between dexamethasone and Cd36-deficient segment of spontaneously hypertensive rat chromosome 4 affects triacylglycerol and cholesterol distribution into lipoprotein fractions [PDF]
Dexamethasone (DEX) is known to induce diabetes and dyslipidemia. We have compared fasting triacylglycerol and cholesterol concentrations across 20 lipoprotein fractions and glucose tolerance in control (standard diet) and DEX-treated 7-month-old males ...
Michaela Krupková +5 more
core +1 more source
In this paper, we describe a common recurrent founder variant in the BRCA gene that was observed in the native Qatari population among high‐risk individuals seen in the cancer genetic clinic at the National Center for Cancer Care and Research. BRCA gene is associated with Hereditary breast and ovarian cancer syndrome (HBOC); it is very common in Qatar ...
Salha Bujassoum Al‐Bader +9 more
wiley +1 more source
Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats [PDF]
This protocol describes the use of in vitro television microscopy to evaluate vascular function in isolated cerebral resistance arteries (and other vessels), and describes techniques for evaluating tissue perfusion using Laser Doppler Flowmetry (LDF) and
Allen, L. Adrienne +6 more
core +1 more source
Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation [PDF]
The interaction of donor passenger leukocytes and host leukocytes in recipient secondary lymphoid tissues during the early posttransplantation period is crucial in directing host immune reactions toward allograft rejection or acceptance.
Akdis +48 more
core +2 more sources
Enhancer Rewiring Orchestrates Inflammation and Loss of Cell Identity During Muscle Stem Cell Aging
A comprehensive multi‐omic profiling of murine muscle stem cells across three ages and both sexes reveals extensive enhancer and 3D genome rewiring, concomitant with increased inflammation, lineage drift, loss of quiescence, and reduced myogenic potential.
Changyou Shi +17 more
wiley +1 more source

