Comparative analysis of methods for gene transcription profiling data derived from different microarray technologies in rat and mouse models of diabetes [PDF]
BACKGROUND: Microarray technologies are widely used to quantify the abundance of transcripts corresponding to thousands of genes. To maximise the robustness of transcriptome results, we have tested the performance and reproducibility of rat and mouse ...
Anita Salhan +6 more
core +3 more sources
Development of the metabolic syndrome is detennined by a complex interaction of environmental and genetic factors and as with other complex human traits, disease gene identification is problematic due to a lack of statistical power and genetic ...
Maciver, Fiona, Maciver, Fiona
core
Reduced Levels of mGlu2 Receptors within the Prelimbic Cortex Are Not Associated with Elevated Glutamate Transmission or High Alcohol Drinking [PDF]
Background A Grm2 cys407* stop codon mutation, which results in a loss of the metabotropic glutamate 2 (mGlu2) receptor protein, was identified as being associated with high alcohol drinking by alcohol-preferring (P) rats.
Bell, Richard L. +5 more
core +1 more source
Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. [PDF]
Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the ...
Carrette, Lieselot LG +7 more
core
Genetic Influences on Brain Gene Expression in Rats Selected for Tameness and Aggression
Inter-individual differences in many behaviors are partly due to genetic differences, but the identification of the genes and variants that influence behavior remains challenging.
Alexander Cagan +16 more
core +1 more source
Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats [PDF]
This protocol describes the use of in vitro television microscopy to evaluate vascular function in isolated cerebral resistance arteries (and other vessels), and describes techniques for evaluating tissue perfusion using Laser Doppler Flowmetry (LDF) and
Allen, L. Adrienne +6 more
core +1 more source
Identification of donor hematopoietic progenitor cells after allogeneic liver transplantation [PDF]
Demetris, AJ +4 more
core +1 more source
Immunological Rejection in a Heterotopic Rat Liver Transplant Model. [PDF]
Thompson C +10 more
europepmc +1 more source

