Results 61 to 70 of about 4,642 (140)
European Journal of Neuroscience, Volume 59, Issue 7, Page 1567-1584, April 2024.Abstract The spontaneously hypertensive rat (SHR) is a selectively bred animal strain that is frequently used to model attention‐deficit hyperactivity disorder (ADHD) because of certain genetically determined behavioural characteristics. To test the hypothesis that the characteristically altered response to positive reinforcement in SHRs may be due to ...
Yu‐Ting Li +4 more
wiley +1 more source
British Journal of Haematology, Volume 207, Issue 2, Page 631-635, August 2025.
Thomas Altmann +11 more
wiley +1 more source
Genes, Brain and Behavior, Volume 23, Issue 2, April 2024.Using the Hybrid Rat Diversity Panel, we demonstrated that sex and genetic background confer differences in mechanical sensitivity, thermal sensitivity, and oxycodone‐induced analgesia. Created with BioRender.com. Abstract Opioid use disorder (OUD) is an ongoing public health concern in the United States, and relatively little work has addressed how ...
Eamonn P. Duffy +7 more
wiley +1 more source
Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats [PDF]
, 2018 Dementia is a major social and economic problem for our aging population. One of the most common of dementia in the elderly is cerebral small vessel disease (SVD). Magnetic resonance scans of SVD patients typically show white matter abnormalities, but we
Atanur, Santosh S. +12 more
core +3 more sources
Drug development advances in human genetics‐based targets
MedComm, Volume 5, Issue 2, February 2024.Progress in drug discovery based on targets with favorable LOF variants identified by WES, WGS, and GWAS. Targets primarily include PCSK9, ANGPTL3, HSD17B13, KHK, ASGR1, GPR75, CIDEB, and INHBE. Drug types primarily include small molecules, monoclonal antibodies, RNAi, and CRISPR gene editing therapies.
Xiaoxia Zhang +5 more
wiley +1 more source
Rodent models of heart failure: an updated review [PDF]
, 2013 Heart failure (HF) is one of the major health and economic burdens worldwide, and its prevalence is continuously increasing. The study of HF requires reliable animal models to study the chronic changes and pharmacologic interventions in myocardial ...
Bras Silva, C +4 more
core +1 more source
Animal models of attention-deficit hyperactivity disorder [PDF]
, 2005 Although animals cannot be used to study complex human behaviour such as language, they do have similar basic functions. In fact, human disorders that have animal models are better understood than disorders that do not.
Russell, Vivienne A +2 more
core +1 more source
Deficits in fine motor skills in a genetic animal model of ADHD [PDF]
, 2010 Background In an attempt to model some behavioral aspects of Attention Deficit/Hyperactivity Disorder (ADHD), we examined whether an existing genetic animal model of ADHD is valid for investigating not only locomotor hyperactivity, but also more complex ...
Yu Qian +4 more
core +2 more sources
Gene expression and microrna expression analysis in small arteries of spontaneously hypertensive rats. Evidence for er stress [PDF]
, 2015 Small arteries are known to develop functional and structural alterations in hypertension. However, the mechanisms of this remodeling are not fully understood.We hypothesized that altered gene expression is associated with the development of ...
Arribas, Silvia M. +9 more
core +5 more sources
Torasemide inhibits angiotensin II-induced vasoconstriction and intracellular calcium increase in the aorta of spontaneously hypertensive rats [PDF]
, 1999 Torasemide is a loop diuretic that is effective at low once-daily doses in the treatment of arterial hypertension. Because its antihypertensive mechanism of action may not be based entirely on the elimination of salt and water from the body, a ...
Diez-Martinez, J. (Javier) +6 more
core +1 more source