Results 51 to 60 of about 23,411 (167)

Organ Specificity and Commonality of Epigenetic Aging in Low‐ and High‐Running Capacity Rats

Aging Cell, Volume 24, Issue 8, August 2025.
Cardiorespiratory fitness (CRF) is not associated with epigenetic clocks, including newly developed ones. On the other hand, CRF is associated with global methylation profiles and promoter methylation in organ‐specific and organ‐common manner. ABSTRACT Epigenetic drift, which is gradual age‐related changes in DNA methylation patterns, plays a ...
Takuji Kawamura, Csaba Kerepesi, Juliet Polok Sarkar, Ferenc Torma, Zoltan Bori, Lei Zhou, Peter Bakonyi, Attila Kolonics, Laszlo Balogh, Mitsuru Higuchi, Vivien Pillár, Karolina Pircs, Lauren Gerard Koch, Steven Loyal Britton, Erika Koltai, Zsolt Radak   +15 more
wiley   +1 more source

Early Onset Memory Deficit of WMI Rats Compared to Their Nearly Isogenic WLIs Is Reversed by Enriched Environment in Females

Genes, Brain and Behavior, Volume 24, Issue 3, June 2025.
Enriched environment housing reverses memory deficits in middle‐aged WMI females and attenuates deficits in WMI males. Plasma levels of estradiol and hippocampal gene expression followed the same pattern as memory in WMI females following environmental enrichment and may be involved in reversing the effects of aging on cognitive decline.
Michelle T. Ji, Katherine J. Przybyl, Aspen M. Harter, Mariya Nemesh, Sophia T. Jenz, Anna Yamazaki, Chris Kim, Megan K. Mulligan, Hao Chen, Eva E. Redei   +9 more
wiley   +1 more source

COMPLEMENT FACTOR B IS A DETERMINANT OF BOTH METABOLIC AND CARDIOVASCULAR FEATURES OF METABOLIC SYNDROME [PDF]

, 2017
CFB (complement factor B) is elevated in adipose tissue and serum from patients with type 2 diabetes mellitus and cardiovascular disease, but the causal relationship to disease pathogenesis is unclear.
Aitman, Timothy J., Alfazema, Neza, Arends, Mark J., Barrier, Marjorie, Carter, Roderick N., Castro Dopico, Xaquin, Coan, Philip, Diaz, Ana Garcia, Jackson-Jones, Lucy, Marion de Proce, Sophie, Morton, Nicholas M., Moss, Julie, Moyon, Ben, Ross, David, Thomson, Adrian J W, Webster, Zoe   +15 more
core   +2 more sources

Genetic Loci Influencing Cue‐Reactivity in Heterogeneous Stock Rats

Genes, Brain and Behavior, Volume 24, Issue 2, April 2025.
A genome‐wide association study characterizing individual differences in cue‐reactivity (sign‐tracking; A) identifies multiple genetic loci, particularly on chromosomes 1 and 18 (B). Multiple candidate genes in these regions were identified, including those with known psychiatric relevance (e.g., Tenm4; C) and novel candidates with heritable ...
Christopher P. King, Apurva S. Chitre, Joel D. Leal‐Gutiérrez, Jordan A. Tripi, Alesa H. Netzley, Aidan P. Horvath, Alexander C. Lamparelli, Anthony George, Connor Martin, Celine L. St. Pierre, Thiago Missfeldt Sanches, Hannah V. Bimschleger, Jianjun Gao, Riyan Cheng, Khai‐Minh Nguyen, Katie L. Holl, Oksana Polesskaya, Keita Ishiwari, Hao Chen, Terry E. Robinson, Shelly B. Flagel, Leah C. Solberg Woods, Abraham A. Palmer, Paul J. Meyer   +23 more
wiley   +1 more source

A Novel Model of Mixed Vascular Dementia Incorporating Hypertension in a Rat Model of Alzheimer's Disease. [PDF]

, 2019
Alzheimer's disease (AD) and mixed dementia (MxD) comprise the majority of dementia cases in the growing global aging population. MxD describes the coexistence of AD pathology with vascular pathology, including cerebral small vessel disease (SVD ...
Ahmadian, Akiyama, Areosa, Attems, Babcock, Bailey, Baker, Baumgart, Beas, Beauchet, Biancardi, Bouras, Bubber, Bueche, Burm, Calkins, Cao, Cerejeira, Cifuentes, Cohen, Coisne, Csiszar, Custodio, de la Torre, De Reuck, Deane, Dey, Di Marco, Donahue, Du, Engelmann, Fan, Farkas, Feihl, Ferrero, Ferri, Fiandaca, Fischer, Frautschy, Galisova, Gallart-Palau, Gattu, Gattu, Ghosh, Giri, Giri, Goel, Goetzl, Gottesman, Grammas, Gratton, Grinberg, Hainsworth, Hainsworth, Harrison, Heagerty, Hebert, Held, Hernandez, Hoshi, Iadecola, Infante-Garcia, Jalal, Jandke, Jellinger, Jiang, Jolivel, Kaiser, Kalaria, Kalinowska, Kanekiyo, Kantak, Katsouri, Kelly, Kelly, Khan, Khoshnam, Kim, Kim, Kitaguchi, Klakotskaia, Koundal, Kovacs, Krebs, Kruyer, Kwon, Lafosse, Lan, Launer, Liu, Liu, Looi, Lukatela, Marfany, McKee, Meissner, Mendez, Meneses, Moody, Munoz-Moreno, Nabika, Ngandu, Oberlin, Okamoto, Petrovitch, Petrovitch, Pirici, Planton, Power, Ramirez-Gomez, Ramos-Rodriguez, Rizzi, Rodrigue, Romer, Sabbatini, Sayed, Schreiber, Sevigny, Shang, Shih, Sicard, Singh, Smith, Staals, Stoiljkovic, Swerdlow, Sydow, Takemori, Tang, Tayebati, Tayebati, Tayebati, Terry, Tomassoni, Traykov, Ueno, Valenti, Varghese, Vedder, Venkat, Venkat, Vinters, Vos, Walker, Wang, Wang, Wardlaw, Weaver, Wennberg, Wimo, Wimo, Xu, Yang, Yang, Yao, Yasar, Yu, Zhang, Zhang, Zhao, Zhou   +160 more
core   +1 more source

Optimization of Ultrasound Extraction of Total Anthocyanin From Berberis kaschgarica Rupr. by Response Surface Methodology and Its Antihypertensive Effect

Food Science &Nutrition, Volume 12, Issue 12, Page 10699-10715, December 2024.
In the current research, an optimized ultrasound‐assisted extraction method was developed for extracting anthocyanin from Berberis kaschgarica Rupr. fruits. The extract was purified and its effects were evaluated against hypertension in the rat model. The developed UAE method was found suitable for high‐yield anthocyanin extraction.
Nawaz Khan, Maierdan Yusufu, Zeynab Ahmadova, Nulibiya Maihemuti, Sendaer Hailati, Ziruo Talihat, Nuerbiye Nueraihemaiti, Dilihuma Dilimulati, Alhar Baishan, Li Duan, Wenting Zhou   +10 more
wiley   +1 more source

Female Wistar Kyoto More Immobile rats with genetic stress hyper‐reactivity show enhanced contextual fear memory without deficit in extinction of fear

European Journal of Neuroscience, Volume 60, Issue 11, Page 6851-6865, December 2024.
Genetically stress hyperreactive females of the Wistar Kyoto More Immobile (WMI) strain have enhanced contextual fear memory with unimpaired extinction in a paradigm modelling posttraumatic stress disorder. Subsequent fasting plasma corticosterone levels and responses to a novel stressor are flattened in WMIs compared to their nearly isogenic Wistar ...
Aspen M. Harter, Mariya Nemesh, Michelle T. Ji, Luca Lee, Anna Yamazaki, Chris Kim, Eva E. Redei   +6 more
wiley   +1 more source

Bleeding Diathesis in Fawn Hooded Rats:Possible Implications for Invasive Procedures and Refinement Strategies [PDF]

, 2015
The Fawn hooded (FH) rat is commonly used in biomedical research. It is widely acknowledged that the FH rat has a bleeding disorder; leading to abundant bleedings.
Arndt, Saskia S, Hellebrekers, Ludo J, Schaap, Manon W H, van Oostrom, Hugo   +3 more
core   +3 more sources

Unmoving and uninflamed: Characterizing neuroinflammatory dysfunction in the Wistar‐Kyoto rat model of depression

Journal of Neurochemistry, Volume 168, Issue 9, Page 2443-2460, September 2024.
We aimed at assessing anxiety‐ and depressive‐like behaviors in Wistar‐Kyoto (WKY) rats and determining whether these were associated to changes in levels of neuroinflammatory markers (Iba‐1, CD86, Ym1, GFAP, S100A10) and mediators (interleukins IL‐1β, IL‐6, TNF‐α) in the prefrontal cortex (PFC), hippocampus, and amygdala.
Miguel Farinha‐Ferreira, Daniela M. Magalhães, Mariana Neuparth‐Sottomayor, Hugo Rafael, Catarina Miranda‐Lourenço, Ana M. Sebastião   +5 more
wiley   +1 more source

Randomized controlled trial of the effect of phytosterols-enriched low-fat milk on lipid profile in Chinese [PDF]

, 2017
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CHENG, KF, Cheung, BMY, Cheung, CL, Ho, DK, Ho, YN, LEE, KY, SING, CW, TSOI, MF   +7 more
core   +1 more source