Results 41 to 50 of about 3,076 (133)
The analgesic efficacy of morphine varies with rat strain and experimental pain model: implications for target validation efforts in pain drug discovery [PDF]
, 2019 BACKGROUND: Translating efficacy of analgesic drugs from animal models to humans remains challenging. Reasons are multifaceted, but lack of sufficiently rigorous preclinical study design criteria and phenotypically relevant models may be partly ...
Abelson, KSP +7 more
core +1 more source
Anhedonia and other reward-related deficits in animal models of psychiatric disorder [PDF]
, 2015 New insights have revealed the complex and heterogeneous nature of reward-related behaviours: not only are different aspects of reward (e.g. reward 'liking' and 'wanting') subserved by dissociable neural mechanisms, but they are differentially ...
Wright, Rebecca
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Rat strains differ in antibody response to Streptobacillus Moniliformis
, 2010 Rats are the natural host of Streptobacillus moniliformis. The bacterium is zoonotic which is an obvious reason for periodic monitoring of rat colonies for S. moniliformis infection.
Boot, R. +5 more
core +1 more source
Behavioral reactivity in spontaneously hypertensive rats
, 1985 Spontaneously hypertensive rats of the Okamoto strain (SHR) were compared with inbred normotensive rats of the Wistar-Kyoto strain (WKY) and with normally bred Wistar rats (NT) in tests on the audiogenic immobility reaction (freezing), open-field ...
Jern, Sverker, +5 more
core
, 2002 This study was designed to determine the association between dietary Mg (Mg) status on induction of hypertension in both normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR).
Lai, Lucinda Man Lai
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Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey
, 2019 Negative affective state has a significant impact on pain, and genetic background is an important moderating influence on this interaction. The Wistar-Kyoto (WKY) inbred rat strain exhibits a stress-hyperresponsive, anxiety/depressive-like phenotype and ...
Madasu, Manish K. +6 more
core +1 more source
, 2003 Millions of children and adults worldwide are diagnosed with Attention-deficit hyperactivity disorder (ADHD) and yet its very existence, definition, and treatment are surrounded with discord and controversy.
Tennison, Linda R. +2 more
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, 1993 The behavioral and neuroendocrine reactivity to a novel environment (open field) and the adrenocorticotropic hormone (ACTH)/corticosterone response to a corticotropin-releasing factor (CRF) challenge were measured in 2-mo-old rats from four inbred ...
Hendley, E.D. +7 more
core +1 more source
Strain and site dependence of polyploidization of cultured rat smooth muscle
, 1986 Smooth muscle cell (SMC) growth may play an important role in the pathogenesis of vascular diseases such as atherosclerosis and hypertension. Recent studies have demonstrated that, under different growth stimuli in vivo, SMC may respond by proliferation ...
Goldberg, Itzhak D. +5 more
core +1 more source
, 2005 Genetic mapping of the progeny of an F2 intercross between WKY and WKHA rats had previously allowed us to detect male-specific linkage between locus Cm24 and left ventricular mass index (LVMI).
Jiang, Z. +4 more
core +1 more source