Results 41 to 50 of about 717,881 (139)

Diurnal behavioral outcomes and BBB integrity in adult male SHR and WKY rats. [PDF]

Sci Rep
Day and night neurobehavioral tests were performed for Spontaneously Hypertensive rats (SHR) and Wistar Kyoto rats (WKY) to establish an optimal testing window. Also, blood–brain barrier (BBB) integrity in brain areas related to cognition was measured to
Shrivastava P, Biose OD, Dahal R, Jwayyed A, Raji RA, Xia H, Lazartigues E, Biose IJ.   +7 more
europepmc   +2 more sources

Optimization of Ultrasound Extraction of Total Anthocyanin From Berberis kaschgarica Rupr. by Response Surface Methodology and Its Antihypertensive Effect

Food Science &Nutrition, Volume 12, Issue 12, Page 10699-10715, December 2024.
In the current research, an optimized ultrasound‐assisted extraction method was developed for extracting anthocyanin from Berberis kaschgarica Rupr. fruits. The extract was purified and its effects were evaluated against hypertension in the rat model. The developed UAE method was found suitable for high‐yield anthocyanin extraction.
Nawaz Khan, Maierdan Yusufu, Zeynab Ahmadova, Nulibiya Maihemuti, Sendaer Hailati, Ziruo Talihat, Nuerbiye Nueraihemaiti, Dilihuma Dilimulati, Alhar Baishan, Li Duan, Wenting Zhou   +10 more
wiley   +1 more source

The plasma insulin levels of GK and WKY rats over time.

, 2023
The plasma insulin levels of GK and WKY rats over time.
Shenghao Cao (16326848), Xiao-ding Peng (17125178), Lei M. Li (16326851), Linting Wang (17125175), Yance Feng (6652652)   +4 more
core   +1 more source

Female Wistar Kyoto More Immobile rats with genetic stress hyper‐reactivity show enhanced contextual fear memory without deficit in extinction of fear

European Journal of Neuroscience, Volume 60, Issue 11, Page 6851-6865, December 2024.
Genetically stress hyperreactive females of the Wistar Kyoto More Immobile (WMI) strain have enhanced contextual fear memory with unimpaired extinction in a paradigm modelling posttraumatic stress disorder. Subsequent fasting plasma corticosterone levels and responses to a novel stressor are flattened in WMIs compared to their nearly isogenic Wistar ...
Aspen M. Harter, Mariya Nemesh, Michelle T. Ji, Luca Lee, Anna Yamazaki, Chris Kim, Eva E. Redei   +6 more
wiley   +1 more source

Photomicrograph of thoracic aorta from treated and untreated WKY rats at 400× magnification.

, 2013
Hematoxylin and eosin stained aorta: A. Control WKY. B. SO treated WKY. C. RPO treated WKY. D. PO treated WKY. No significant changes were observed in the aortic media thickness between the treated and control WKY rats.
Chee-Meng Boon (284217), Mei-Han Ng (284218), Shiueh-Lian Mok (284220), Yuen-May Choo (284219)   +3 more
core   +1 more source

Unmoving and uninflamed: Characterizing neuroinflammatory dysfunction in the Wistar‐Kyoto rat model of depression

Journal of Neurochemistry, Volume 168, Issue 9, Page 2443-2460, September 2024.
We aimed at assessing anxiety‐ and depressive‐like behaviors in Wistar‐Kyoto (WKY) rats and determining whether these were associated to changes in levels of neuroinflammatory markers (Iba‐1, CD86, Ym1, GFAP, S100A10) and mediators (interleukins IL‐1β, IL‐6, TNF‐α) in the prefrontal cortex (PFC), hippocampus, and amygdala.
Miguel Farinha‐Ferreira, Daniela M. Magalhães, Mariana Neuparth‐Sottomayor, Hugo Rafael, Catarina Miranda‐Lourenço, Ana M. Sebastião   +5 more
wiley   +1 more source

Effect of FAAH inhibition on BDNF, AEA and CB1 function in the brain of WKY rats.

, 2013
Basal BDNF levels were found to be significantly lower in frontal cortex (27%) and hippocampus (26%) of WKY compared to WIS rats ...
Basalingappa L. Hungund (323107), K. Yaragudri Vinod (323103), Shanaz M. Tejani-Butt (323109), Delphine Psychoyos (323106), Shan Xie (323105), Thomas B. Cooper (323108)   +5 more
core   +1 more source

Spontaneous vascular dysfunction in Dahl salt‐sensitive male rats raised without a high‐salt diet

Physiological Reports, Volume 12, Issue 14, July 2024.
Abstract Dahl salt‐sensitive (SS) rats fed a high‐salt diet, but not low‐salt, exhibit vascular dysfunction. Several substrains of SS rats exist that differ in their blood pressure phenotypes and salt sensitivity. The goal of this study was to investigate whether the John‐Rapp‐derived SS rat (SS/Jr), which exhibits spontaneous hypertension on a low ...
Arturo Grano de Oro, Sanjana Kumariya, Blair Mell, Jasenka Zubcevic, Bina Joe, Islam Osman   +5 more
wiley   +1 more source

Comparative assessment of CacyBP/SIP, β‐catenin and cannabinoid receptors in the adrenals of hypertensive rats

Journal of Cellular and Molecular Medicine, Volume 28, Issue 10, May 2024.
Abstract Taking into account homeostatic disorders resulting from arterial hypertension and the key importance of CacyBP/SIP, β‐catenin and endocannabinoids in the functioning of many organs, it was decided to assess the presence and distribution of CacyBP/SIP, β‐catenin, CB1 and CB2 in the adrenal glands of hypertensive rats of various aetiology.
Magdalena Smereczańska, Natalia Domian, Alicja Lewandowska, Irena Kasacka   +3 more
wiley   +1 more source

Phasic dopamine signals are reduced in the spontaneously hypertensive rat and increased by methylphenidate

European Journal of Neuroscience, Volume 59, Issue 7, Page 1567-1584, April 2024.
Abstract The spontaneously hypertensive rat (SHR) is a selectively bred animal strain that is frequently used to model attention‐deficit hyperactivity disorder (ADHD) because of certain genetically determined behavioural characteristics. To test the hypothesis that the characteristically altered response to positive reinforcement in SHRs may be due to ...
Yu‐Ting Li, Yi‐Ling Huang, Jia‐Jin Jason Chen, Brian Ian Hyland, Jeffery R. Wickens   +4 more
wiley   +1 more source