Using the Hybrid Rat Diversity Panel, we demonstrated that sex and genetic background confer differences in mechanical sensitivity, thermal sensitivity, and oxycodone‐induced analgesia. Created with BioRender.com. Abstract Opioid use disorder (OUD) is an ongoing public health concern in the United States, and relatively little work has addressed how ...
Eamonn P. Duffy +7 more
wiley +1 more source
Basal differences in AEA and FAAH levels in the brain of WKY rats.
The level of eCB, AEA was found to be significantly lower in hippocampus of WKY rats compared to WIS rats (31 ...
Basalingappa L. Hungund (323107) +5 more
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Electroacupuncture improves depression with constipation by balancing gut microbiota in WKY rats [PDF]
Accumulating evidence underscores the pivotal role of the gut microbiota in the pathogenesis of depression. In this study, we employed the Wistar-Kyoto (WKY) rat, a well-established animal model of depression comorbid with constipation.
Kaiyu Cui +6 more
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Relationship between dietary sodium intake, hemodynamics, and cardiac mass in SHR and WKY rats
To study the effects of sodium intake on circulatory homeostasis and cardiac structure, changes in cardiac mass, systemic hemodynamics, and organ blood flows were determined in spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats ...
Y. Chien +3 more
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Gestational Plasma Aldosterone Concentration in SHR and WKY Rats on Normal and Low Sodium Diets
educed perinatal sodium intake attenuates the development of hypertension in the SHR. Stimulation of the renin-angiotensin-aldosterone system by low sodium diets is well documented in non-pregnant rats, but not well documented in pregnant SHR rats.
Abraha, A., Magnuson, B., Dalerg, T.J.
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Vascular effects of R-568 in MVB from WKY and SHR rats.
Mesenteric vascular beds (MVB) from 8-week old WKY and SHR rats were isolated and prepared as described in Methods. PP at approximately 120 mmHg was maintained by continuous infusion with NA (10 μM and 3 μM in WKY and SHR rats, respectively). (A) and (B)
Domitilla Mandatori (5617583) +12 more
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Basal differences in CB1 receptor in the brain of WKY rats.
The CB1 receptor agonist-stimulated [35S]GTPγS binding was significantly higher in frontal cortex (24 ...
Basalingappa L. Hungund (323107) +5 more
core +1 more source
Impulsive choice behavior in four strains of rats: evaluation of possible models of Attention Deficit/Hyperactivity Disorder [PDF]
Several studies have examined impulsive choice behavior in spontaneously hypertensive rats (SHRs) as a possible pre-clinical model for Attention-Deficit/Hyperactivity Disorder (ADHD).
Garcia, Ana, Kirkpatrick, Kimberly
core
Effect of FAAH inhibition on depressive-like behavior in WKY rats.
Treatment with URB597 (0.3 mg/kg, i.p.
Basalingappa L. Hungund (323107) +5 more
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Blood pressure, plasma catecholamines, and sympathetic outflow in pithed SHR and WKY rats
After destruction, by pithing, of the central nervous system, the blood pressure (BP) of the spontaneously hypertensive (SHR) rat falls, but remains higher than in the pithed normotensive (WKY) rat.
I. Yamaguchi, I. J. Kopin
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