Animal models of attention-deficit hyperactivity disorder [PDF]
, 2005 Although animals cannot be used to study complex human behaviour such as language, they do have similar basic functions. In fact, human disorders that have animal models are better understood than disorders that do not.
Russell, Vivienne A +2 more
core +1 more source
Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans [PDF]
, 2017 Compelling evidence for the inherited nature of essential hypertension has led to extensive research in rats and humans. Rats have served as the primary model for research on the genetics of hypertension resulting in identification of genomic regions ...
Allbutt TC +34 more
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Sex differences in primary hypertension [PDF]
, 2012 Men have higher blood pressure than women through much of life regardless of race and ethnicity. This is a robust and highly conserved sex difference that it is also observed across species including dogs, rats, mice and chickens and it is found in ...
Kathryn Sandberg, Hong Ji
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Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats [PDF]
, 2000 This study was designed to test the hypothesis that stimulation of nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate (NADH/NADPH) oxidase is involved in increased vascular superoxide anion (*O(2)(-)) production in ...
Beaumont, J. (Javier) +6 more
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Reduced Levels of mGlu2 Receptors within the Prelimbic Cortex Are Not Associated with Elevated Glutamate Transmission or High Alcohol Drinking [PDF]
, 2017 Background A Grm2 cys407* stop codon mutation, which results in a loss of the metabotropic glutamate 2 (mGlu2) receptor protein, was identified as being associated with high alcohol drinking by alcohol-preferring (P) rats.
Bell, Richard L. +5 more
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Deficits in fine motor skills in a genetic animal model of ADHD [PDF]
, 2010 Background In an attempt to model some behavioral aspects of Attention Deficit/Hyperactivity Disorder (ADHD), we examined whether an existing genetic animal model of ADHD is valid for investigating not only locomotor hyperactivity, but also more complex ...
Yu Qian +4 more
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Pre-reproductive parental enriching experiences influence progeny’s developmental trajectories [PDF]
, 2018 While the positive effects of environmental enrichment (EE) applied after weaning, in adulthood, during aging, or even in the presence of brain damage have been widely described, the transgenerational effects of pre-reproductive EE have been less ...
Berretta, Erica +5 more
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Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis [PDF]
, 2018 • Cyp2j4 deletion in rats offers a simplified genetic landscape as opposed to the mice locus, which is under significant allelic expansion. • Under different metabolic stresses (aging, cafeteria diet), Cyp2j4−/− rats show an accelerated adipogenesis ...
Abraham +71 more
core +4 more sources
Fine mapping of bone structure and strength QTLs in heterogeneous stock rat [PDF]
, 2015 We previously demonstrated that skeletal structure and strength phenotypes vary considerably in heterogeneous stock (HS) rats. These phenotypes were found to be strongly heritable, suggesting that the HS rat model represents a unique genetic resource for
Alam, Imranul +16 more
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High-resolution genome screen for bone mineral density in heterogeneous stock rat [PDF]
, 2014 We previously demonstrated that skeletal mass, structure, and biomechanical properties vary considerably in heterogeneous stock (HS) rat strains. In addition, we observed strong heritability for several of these skeletal phenotypes in the HS rat model ...
Alam, Imranul +15 more
core +1 more source