Results 111 to 120 of about 325,138 (309)

Splenic Hemangiosarcoma in a Young Sprague-Dawley Rat

Journal of Toxicologic Pathology, 2012
The present report describes a rare case of spontaneous hemangiosarcoma in a nine-week-old male Sprague-Dawley rat. At necropsy, multiple white nodules of various sizes were observed on and within the enlarged spleen and liver and were histopathologically determined to be composed of spindle- to oval-shaped cells that showed invasive growth without ...
Shiraki, Katsuhisa, Ono, Mihoko, Kajikawa, Satoru, Takeuchi, Ayano, Murakami, Yuichi, Oishi, Yuji, Matsumoto, Masahiro   +6 more
openaire   +3 more sources

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Female Sprague Dawley Rats Show Impaired Spatial Memory in the 8-Arm Radial Maze under Dim Blue and Red Light

International Journal of Zoology, 2010
Light intensity and wavelength strongly influence mood and cognition in humans and rodent animal models. The aim of the present study was to explore if dim white (7.6–17.7 lux) , blue (1.3–2.3 lux), and red light (0.8–1.4 lux) affect spatial memory of ...
Michael Pirchl, Georg Kemmler, Christian Humpel   +2 more
doaj   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Effect of 3β, hydroxy-lup-20(29)-en-28-oic acid on 7,12-Dimethylbenz(a) anthracene impaired cellular homeostasis in extrahepatic organs of Sprague Dawley rats

Journal of Xenobiotics, 2017
3β, hydroxy-lup-20(29)-en-28-oic acid (Betulinic acid), a pentacyclic lupane-type triterpene has diverse pharmacological functions both in vitro and in vivo.
Pardeep Kaur, Rajbir Kaur, Rohit Arora, Saroj Arora   +3 more
doaj   +1 more source

Strain specific effects of low level lead exposure on associative learning and memory in rats. [PDF]

, 2017
Exposure to lead (Pb) remains a significant public health concern. Lead exposure in early life impairs the normal development of numerous cognitive and neurobehavioral processes.
Schneider, J. S., Verma, Megha
core   +2 more sources

Spontaneous Rhabdomyosarcoma in a Young Sprague-Dawley Rat [PDF]

Veterinary Pathology, 1994
I Day MJ, Penhale WJ: An immunohistochemical study of canine disseminated aspergillosis. Aust Vet J 68:383386, 1991 2 Day MJ, Penhale WJ, Eger CE, Shaw SE, Kabay MJ, Robinson WF, Huxtable CRR, Mills JN. Wyburn RS: Disseminated aspergillosis in dogs. Aust Vet J 68:55-59, 1986 3 Greene CE, Chandler FW: Candidiasis.
openaire   +2 more sources

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

A novel Osteoarthritis scoring system to separate typical OA joint degeneration from non-typical lesions in male Sprague Dawley rats

Osteoarthritis and Cartilage Open
Objective: To develop a novel scoring system to characterize osteoarthritis-related degeneration distinct from spontaneous subchondral bone lesions observed in the tibia and femur of male Sprague Dawley rats.
Nada Abughazaleh, Ruth-Anne Seerattan, David A. Hart, Raylene A. Reimer, Walter Herzog   +4 more
doaj   +1 more source

Tissue compatibility of poly(hydroxypropylglutamate)-prazosin conjugates [PDF]

, 1992
Biocompatibility of an injectable biodegradable drug delivery system for prazosin was investigated in Sprague-Dawley rats by histological studies after subcutaneous injection ofpoly(hydroxypropyl glutamate)-prazosin (PHPG-prazosin) conjugate particles ...
Anderson, James M., Feijen, Jan, Kim, Sung Wan, Li, Xiaoling, Yamaguchi, Kazuhiro   +4 more
core   +2 more sources