Results 311 to 320 of about 427,760 (358)

Prostate cancer in a Sprague‐Dawley rat

The Prostate, 1985
AbstractAn adenocarcinoma of the prostate gland developed in one rat of the Lobund Sprague‐Dawley (S‐D) strain, following treatments with testosterone propionate in silastic membranes. The transplanted cells (PA‐SD1) developed local tumors, metastasized through lymphatic channels to the lungs, and induced osteolytic lesions when deposited adjacent to ...
Morris Pollard, Phyllis H. Luckert
openaire   +4 more sources

Leiomyoma of the iris in a Sprague-Dawley rat

Journal of Comparative Pathology, 1987
A leiomyoma of the iris was composed of bundles of spindle-shaped cells with abundant myoglial fibres and represents the first observation of this rare tumour in a rat.
P Duprat, R.A Owen
openaire   +3 more sources

Behavioral heterogeneity in Sprague-Dawley rats

Physiology & Behavior, 1992
Because of consistent individual differences in animal behavior, it is often difficult to interpret experimental data. We therefore attempted to rank Sprague Dawley rats by a hierarchical ascendant clustering technique using data from avoidance conditioning and open-field testing (scores of exploratory activity before, during, and after an ...
M. Curé, J.P. Rolinat
openaire   +3 more sources

Spontaneous Hibernomas in Sprague-Dawley Rats

Toxicologic Pathology, 2009
Hibernomas are rare neoplasms originating in brown adipose tissue of humans and other animal species, including laboratory animals. Background incidence values for these tumors in all common strains of laboratory rats are generally accepted as being <0.1%.
Richard H. Bruner, Wade B. Lawrence, Kathryn L. Scully, David G. Peters, Catherine A. Picut, Thomas P. O’Neill, Brett H. Saladino, Jeannie B. Kirkpatrick, George A. Parker, Dawn G. Goodman, Meliton N. Novilla   +10 more
openaire   +3 more sources

Postirradiation Sarcomas in Sprague-Dawley Rats

Radiation Research, 1998
A series of radiation-induced neoplasms occurred in Sprague-Dawley rats 4-8 months after irradiation of a single hind leg with 60Co gamma rays. The rats were exposed to fractionated cumulative doses that ranged from 0 to 106 Gy. Osteosarcomas, malignant fibrous histiocytomas and fibrosarcomas developed in the radiation fields of a number of the rats in
Peggy T. Tinkey, Gregory R. D. Evans, Kenneth N. Gray, Roger E. Price, Jack H. Cundiff, Thomas M. Lembo   +5 more
openaire   +3 more sources

Intrauterine Expression of Prothrombin in the Sprague-Dawley Rat

Journal of the Society for Gynecologic Investigation, 2002
Thrombin appears to underlie myometrial contractions in response to intrauterine bleeding. In a similar fashion, thrombin generated within the uterus in the absence of active bleeding could also produce contractions. These studies sought to determine whether functionally active prothrombin is expressed in the pregnant and nonpregnant rat uterus.
Mark Phillippe, Leandra Thomas, Trevania Saunders, Jeffrey Chapa, David Wolff   +4 more
openaire   +3 more sources

Carcinogenicity of 4-chloronitrosopiperidine in Sprague-Dawley rats

Zeitschrift f�r Krebsforschung und Klinische Onkologie, 1978
4-Chloronitrosopiperidine was administered to a group of 15 male Sprague-Dawley rats as a 0.005% solution in drinking water for 27 weeks. Of the 15 animals, 12 died with tumors induced by the treatment, half of them by the 41 st week; all 15 were dead at 58 weeks.
H. W. Taylor, W. Lijinsky
openaire   +3 more sources