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Olanzapine Induced Thrombocythemia in Sprague‐Dawley Rats
Drug and Chemical Toxicology, 2004Olanzapine was administered orally (20 mg/kg/day) in Sprague-Dawley rats. Forty-eight male Sprague-Dawley rats were divided into eight groups of six animals each. Four groups of animals received olanzapine for 7, 14, 21 and 48 days. There were no significant changes in hematological, clinical biochemistry parameters and superoxide dismutase activity in
Harish Padh +3 more
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Spontaneous leukaemia in a sprague-dawley rat
Experientia, 1962Description d'un cas de chloroleucemie myeloide chez un rat de souche Sprague-Dawley, presentant quelques modifications peu communes des tubes renaux.
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The nephrotoxic potential of styrene in sprague-dawley rats
Toxicology Letters, 1983Pre-fasted (16 h) Sprague-Dawley male rats were treated i.p. with 0, 0.2, 0.4, 0.8 and 1.2 g/kg of styrene in corn oil. Renal functions were assessed at 0-24, 24-48 and 48-72 h after the exposure. Urinary creatinine was decreased at 0.8 g/kg of styrene during 0-24 h after the treatment compared to control, whereas such a decrease was noticed in 1.2 g ...
Jules Brodeur, Saroj K. Chakrabarti
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Respiration in Sprague-Dawley Rats During Pregnancy
Inhalation Toxicology, 2006Minute ventilation and tidal volume increase in humans during pregnancy. Little data exists, however, on the respiration in pregnant rats, despite their widespread use as an animal model. Since respiration will affect the pharmacokinetics of volatile compounds and ultimately the dose to the fetus, we conducted a study to evaluate respiration in rats ...
David C. Dorman +5 more
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Lactational transfer of bisphenol A in Sprague–Dawley rats
Toxicology Letters, 2010Bisphenol A (BPA), an important industrial chemical to which humans are exposed on a daily basis, has long been associated with endocrine disruption in experimental animal models. Such exposures are of concern, particularly during fetal and early neonatal periods, because of greater vulnerability of developing organs to aberrant endocrine signaling ...
Michelle Vanlandingham +3 more
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Toxicity Studies of Epichlorohydrin in Sprague-Dawley Rats
Drug and Chemical Toxicology, 1996Adult male and female Sprague-Dawley rats received epichlorohydrin via gavage in distilled water for 10 consecutive days at dose levels of 3, 7, 19, and 46 mg/kg-day, and for 90 days at dose levels of 1, 5, and 25 mg/kg-day. Epichlorohydrin did not adversely effect mortality, but toxicity, at the higher doses, was evident by: 1) losses in body weight ...
Greg R. Olson +3 more
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The Journal of Phytopharmacology, 2014
The present study was carried out to evaluate the hepatoprotective effects of aqueous extract of Xylopia aethiopica stem bark (XASB) on carbon tetrachloride (CCl4) induced liver damage in sprague dawley rats.
O. Adewale +4 more
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The present study was carried out to evaluate the hepatoprotective effects of aqueous extract of Xylopia aethiopica stem bark (XASB) on carbon tetrachloride (CCl4) induced liver damage in sprague dawley rats.
O. Adewale +4 more
semanticscholar +1 more source
Spontaneous brain tumours in Sprague-Dawley rats
Food and Chemical Toxicology, 1986Data were collected over a 5-yr period on brain tumours occurring spontaneously among Sprague-Dawley-derived rats in the HRC laboratories. Gliomas, like meningiomas, tended to occur more among males than in females, and in general appeared to be lesions of older rats. Astrocytic tumours of rats were less differentiated than those in man.
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Disposition of butadiene epoxides in Sprague-Dawley rats
Chemico-Biological Interactions, 19971,2-Epoxybutene (BMO) and diepoxybutane (BDE) are metabolic products of 1,3-butadiene in rodents. Both BMO and BDE are suspect in the development of tumors in rats and mice. To understand the distribution and elimination of these compounds in the absence of the rate-limiting production from butadiene, the pharmacokinetics of BMO and BDE in blood were ...
Lisa M. Sweeney +7 more
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Carcinogenic Effects of Diisopropanolnitrosamine in Sprague-Dawley Rats
JNCI: Journal of the National Cancer Institute, 1977The carcinogenic effects of diisopropanolinitrosamine (DIPN) were tested in Sprague-Dawley rats and were then compared with results produced earlier by the same substance in Syrian hamsters. In addition to the similarities, several differences were noted; for example, DIPN caused pancreatic tumors in all the hamsters, but only 1 pancreatic tumor was ...
Parviz M. Pour, Gerd Reznik, Ulrich Mohr
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