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Spontaneous endocrine tumors in Sprague-Dawley rats
Journal of Cancer Research and Clinical Oncology, 1979Spontaneous endocrine tumors were found in 81 of 100 Sprague-Dawley rats (42 males and 39 females) which survived for more than 2 years. Most of these tumors were medullary carcinomas of the thyroid, followed by tumors of the anterior pituitary gland, pheochromocytomas and cortical adenomas of the adrenal gland, and islet cell tumors of the pancreas ...
G. Kimmerle, Ulrich Mohr, H. Suzuki
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Immunolocalization of Ghrelin in the Stomach of Sprague‐Dawley Rat
Anatomia, Histologia, Embryologia, 2010With 3 figures and 1 tableSummaryTo investigate the distribution of ghrelin in different regions of stomach in Sprague‐Dawley rat, and attempt to compare with those of humans and other mammalian species in this study, the stomach of rats was divided into five sections, cardia, fundus, greater curvature, lesser curvature and pylorus ...
Shuang-Qin Yi +7 more
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Developmental Toxicity of Thiodiglycol in Sprague-Dawley Rats
International Journal of Toxicology, 2007Thiodiglycol (TG), a hydrolysis product of sulfur mustard (HD), is a potential contaminant of soil and water at certain military sites. To establish developmental toxicity criteria for TG, an oral developmental toxicity study was conducted in Sprague-Dawley rats.
Lee C. B. Crouse +4 more
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Spontaneous neoplasms in aged sprague-dawley rats
Archives of Toxicology, 1992Incidence of neoplastic lesions in untreated Sprague-Dawley rats (1340 males and 1329 females) used as controls in 17 carcinogenicity studies are tabulated and evaluated. In male rats, the most common neoplasms were benign pheochromocytomas and keratoacanthomas (4.0% in each case) followed by pancreatic islet cell adenomas (3.7%), thyroid ...
Dale E. Johnson +2 more
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Carcinogenicity of 8-nitroquinoline in Sprague—Dawley rats
Cancer Letters, 19788-Nitroquinoline was added to the semisynthetic diet of outbred Sprague-Dawley rats for 48 weeks. Squamous cell carcinomas of the upper digestive tract (tongue and esophagus), but especially of the forestomach, occurred among the higher concentration groups.
Nobuyuki Ito +5 more
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Cardiac anaphylaxis in the Sprague-Dawley rat.
The Journal of laboratory and clinical medicine, 1992Anaphylactic shock was induced in pentobarbital-anesthetized, mechanically ventilated Sprague-Dawley rats that had been sensitized 21 days earlier to crystallized ovalbumin. The sensitization was confirmed by passive cutaneous anaphylaxis test. Antigen challenge produced an immediate reduction in mean aortic pressure from 168 to 67 mm Hg within 1 ...
Max Harry Weil +6 more
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Carcinogenicity of nitrosoazetidine and tetradeuteronitrosoazetidine in sprague-dawley rats
Zeitschrift f�r Krebsforschung und Klinische Onkologie, 1977Nitrosoazetidine was fed to rats in drinking water at three different concentrations. At 2 mmol (10 mmol total dose) all of the rats died with hepatocellular carcinomas by the 62nd week. This was a greater response than to an equivalent dose of nitrosopyrrolidine. At 0.67 mmol, 6 of 21 rats developed liver tumors, and at 0.17 millimolar 2 of 30 animals
W. Lijinsky, H. W. Taylor, H. W. Taylor
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Polycystic kidney disease in Sprague-Dawley rats
Experimental and Toxicologic Pathology, 2015Polycystic kidney disease (PKD) is a cystic genetic disorder of the kidneys which is typically associated with cystic bile duct dilatation in the liver in humans, and domestic and laboratory animals. In humans, there are two types of PKD, autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD ...
Ahmed M. Shoieb, Norimitsu Shirai
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Sugar-Induced Hypertension in Sprague-Dawley Rats
American Journal of Hypertension, 1991Male Sprague-Dawley rats were fed either conventional rat chow, or a diet in which vegetable starch was replaced with either glucose or sucrose for two weeks. At the end of this period, measurements were made of weight, blood pressure, and plasma glucose, insulin, and triglyceride concentrations.
Helen Ho, Gerald M. Reaven
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Leiomyoma of the Iris, Sprague-Dawley Rat
1991Because of their small size, intraocular location, and rarity, these tumors have not been seen grossly at necropsy. Subgrossly, they are small mesenchymal tumors confined to and distorting the iris (Fig. 47). It can be envisaged that an ophthalmologic examination would reveal a nodular growth that distorts the iris and the pupil and normal pupillary ...
Pierre Duprat, Roger A. Owen
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