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Genotoxicity of nimesulide in Wistar rats
Drug and Chemical Toxicology, 2013It is mandatory for all new drugs to be tested for their potential genotoxicity in addition to general toxicity testing. Some old drugs have not been tested adequately for their genotoxic effects because these were in use before the local regulations were enforced. According to the material safety database, the toxicological effect of nimesulide is not
Subas Chandra Parija +3 more
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Spontaneous Immunoglomerulonephritis in Wistar Rats
Pathology - Research and Practice, 1980A strain of rats bred at the Nuclear Study Center of Mol (C.E.N.) develops a nephropathy characterized by granular deposition of immunoglobulin and complement in the renal glomeruli and tubules. We have attempted to specify the complement activation pathways (classical or alternate) in this disease by looking for their initial components (C1q, C3 and ...
Angela Fridman-Manduzio +2 more
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METABOLISM OF MYOSMINE IN WISTAR RATS
Drug Metabolism and Disposition, 2005The alkaloid myosmine is present not only in tobacco products but also in various foods. Myosmine is easily nitrosated, yielding 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and the esophageal tobacco carcinogen N'-nitrosonornicotine. Due to its widespread occurrence, investigations on the metabolism and activation of myosmine are needed for risk ...
Stefan Tyroller +2 more
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, 2019
Histological effects of Monosodium glutamate (MSG) commonly used as food additive on the liver of adult Wistar rats were carefully studied. The rats of both sexes (n=24), average weight of 185g were randomly assigned into two treatments (n=16) and ...
A. O. Eweka
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Histological effects of Monosodium glutamate (MSG) commonly used as food additive on the liver of adult Wistar rats were carefully studied. The rats of both sexes (n=24), average weight of 185g were randomly assigned into two treatments (n=16) and ...
A. O. Eweka
semanticscholar +1 more source
Spontaneous Neoplasms in Control Wistar Rats
Toxicological Sciences, 1994Neoplastic data on 1370 control Wistar rats from 10 carcinogenicity bioassays done between 1980 and 1990 were reviewed. Mean percentage survival at 104 weeks was 58% for males and 59% for females. A total of 1857 neoplasms were diagnosed in 466 (68%) male and 582 (85%) female rats; 1390 were benign and 467 were malignant (12% with metastasis).
James Poteracki, Kathleen M. Walsh
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Acetaminophen nephrotoxicity in male Wistar rats
Archives of Toxicology, 1992Acute acetaminophen (APAP) nephrotoxicity was studied in male Wistar rats 1 h after different APAP single doses (200, 500 and 1000 mg/kg body wt, i.p.). Significant impairments in glomerular filtration rate (GFR) and clearance of p-aminohippuric acid (ClPAH) were observed in a dose-dependent way, although tubular parameters measured, water and ...
María Mónica Elías +2 more
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Induced palatal candidosis in the Wistar rat
Archives of Oral Biology, 1981Palatal candidosis was induced by inoculating Candida albicans 3091 (serotype A) under an acrylic appliance. After 1 week, the palatal epithelium showed acute inflammatory cell infiltration and surface colonization by blastospores. Two weeks after inoculation, the inflammation had increased, micro-abscesses were observed and fungal hyphae penetrated ...
B.S. Shakir, M.V. Martin, C.J. Smith
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A supernumerary forelimb in a Wistar rat
Laboratory Animals, 1987A fifth limb, quite independent of the others, was found in a pup born in our colony of Wistar rats. The malformation is described.
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The fate of oxalic acid in the Wistar rat
Xenobiotica, 19811. An established procedure for determining oxalate in human urine has been modified for rat urine. The daily excretion of oxalate by the male Wistar rat is 570-650 microgram. 2. Oxalate excretion in rat urine following i.p. administration of [14C]oxalic acid (1-70 mg/kg) has been studied. The rate and degree of excretion are dose-dependent. 3.
Penny Gadiel +2 more
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Hepatotoxicity of graphene oxide in Wistar rats
Environmental Science and Pollution Research, 2020Graphene oxide (GO) has a multitude of applications in areas of nanomedicine, electronics, textile, water purification, and catalysis among others. GO is relatively easier to manufacture and customize as compared with other carbon-based nanomaterials.
Naresh K. Nirmal +2 more
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