Results 1 to 10 of about 165,253 (120)
DAXX-ATRX regulation of p53 chromatin binding and DNA damage response
Nature Communications, 2022 The tumor suppressor proteins DAXX and ATRX are frequently mutated in cancers with alternative lengthening of telomeres (ALT). This study shows that DAXX-ATRX regulates p53 chromatin accessibility and DNA damage response and that disruption of this ...
Nitish Gulve +8 more
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Hepatitis B virus polymerase-specific T cell epitopes shift in a mouse model of chronic infection
Virology Journal, 2021 Background Chronic hepatitis B virus (HBV) infection (CHB) is a significant public health problem that could benefit from treatment with immunomodulators. Here we describe a set of therapeutic HBV vaccines that target the internal viral proteins. Methods
Mohadeseh Hasanpourghadi +6 more
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Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy
Nature Communications, 2021 Immune checkpoint therapies (ICT) are promising for treating various cancers, but response rates vary. Here the authors show, in mouse models, that tumor-infiltrating mast cells colocalize with regulatory T cells, coincide with local reduction of MHC-I ...
Rajasekharan Somasundaram +56 more
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Nature Communications, 2021 One type of RNA editing involves ADAR-mediated conversion of adenosine to inosine. Here the authors show that ADAR1 nuclear isoform p110 regulates R loop formation and genome stability at telomeres in cancer cells.
Yusuke Shiromoto +4 more
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Neutralization of hepatitis B virus by a novel DNA-encoded monoclonal antibody
Human Vaccines & Immunotherapeutics, 2020 Hepatitis B virus (HBV) causes a potentially life-threatening liver infection that frequently results in life-long chronic infection. HBV is responsible for 887,000 deaths each year, most resulting from chronic liver diseases and hepatocellular carcinoma.
Urvi S. Zankharia +10 more
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A deep learning approach reveals unexplored landscape of viral expression in cancer
Nature Communications, 2023 Here, Elbasir et al. develop viRNAtrap, a deep learning approach for detection of viruses from tumor RNA sequencing data, which they showcase on an RNA dataset of different cancer types, revealing tumor expression of divergent viruses that had not been ...
Abdurrahman Elbasir +11 more
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ARID1A mutation and genomic stability
Molecular & Cellular Oncology, 2020 We have recently discovered that AT-rich interactive domain-containing protein 1A (ARID1A) protects telomere cohesion through regulation of the cohesin subunit stromal antigen 1 (STAG1).
Timothy Nacarelli +3 more
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Human Vaccines & Immunotherapeutics, 2020 Significant concerns have arisen over the past 3 y from the increased global spread of the mosquito-borne flavivirus, Zika. Accompanying this spread has been an increase in cases of the devastating birth defect microcephaly as well as of Guillain–Barré ...
Hyeree Choi +16 more
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Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
Nature Communications, 2021 The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can ...
Jianhuang Lin +13 more
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CTCF driven TERRA transcription facilitates completion of telomere DNA replication
Nature Communications, 2017 TERRA RNA is involved in maintaining stability during telomere repeat replication. Here the authors, by using CRISPR/Cas9, mutate CTCF-binding sites at start site of TERRA transcripts and find that subtelomeric CTCF facilitates telomeric DNA replication ...
Kate Beishline +5 more
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