Results 11 to 20 of about 165,402 (265)
Observations on Leukemia in Wistar and Wistar Furth Rats [PDF]
Blood, 1965 Abstract 1. Six-hundred and seventy-three Wistar and W/Fu rats were treated at the age of 4 months with whole body x-ray, orally administered 3MCA or a combination of these agents. All animals were followed until death and 87 per cent were autopsied. 2. Among 303 autopsied animals there were 403 benign and malignant tumors,
W C, MOLONEY, A E, BOSCHETTI, G, DOWD
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Ototoxicity of cypermethrin in Wistar rats
Brazilian Journal of Otorhinolaryngology, 2020 This study presents the effect of cypermethrin on the cochlear function in Wistar rats post-subchronic inhalation exposure. Worldwide several pesticides are described as causing health disorders. Cypermethrin is currently one of the most commonly used, however, little is known about its harmful effects, especially related to hearing. Human studies have
Eduarda Oliveira Cunha +4 more
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Epigenetic specifications of host chromosome docking sites for latent Epstein-Barr virus
Nature Communications, 2020 Epstein-Barr virus (EBV) episomes tether to the host chromosome via EBNA1. Here, using circular chromosome conformation capture (4C), Kim et al. identify attachment sites and show that EBV episomes preferentially associate with transcriptionally silenced
Kyoung-Dong Kim +8 more
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COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions
mBio, 2021 A state of hyperinflammation and increased complement activation has been associated with coronavirus disease 2019 (COVID-19) severity. However, the pathophysiological mechanisms that contribute to this phenomenon remain mostly unknown.
Opeyemi S. Adeniji +15 more
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Structural and functional analysis of the human POT1-TPP1 telomeric complex
Nature Communications, 2017 POT1 and TTP1 are part of the shelterin complex that caps and stabilizes the ends of telomeres. Here the authors present a structural analysis of the human POT1-TTP1 complex, shedding light on how it assembles and how cancer-associated mutations impact ...
Cory Rice +8 more
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Pol α-primase dependent nuclear localization of the mammalian CST complex
Communications Biology, 2021 Kelich, Papaioannou and Skordalakes investigate the intracellular localization dynamics of the mammalian CST, a protein complex critical for telomere maintenance and homeostasis.
Joseph M. Kelich +2 more
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Telomeres and Viruses: Common Themes of Genome Maintenance
Frontiers in Oncology, 2012 Genome maintenance mechanisms actively suppress genetic instability associated with cancer and aging. Some viruses provoke genetic instability by subverting the host’s control of genome maintenance.
Zhong eDeng +2 more
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Spontaneous Cholangiofibrosis in a Wistar Rat [PDF]
Toxicologic Pathology, 2019 In a 2-year carcinogenicity study, we identified a spontaneous cholangiofibrosis in a control male Wistar rat. This lesion has long been considered as a compound-related change, with no spontaneous cases reported in the Wistar rat. In addition to routine hematoxylin and eosin stains evaluation, we applied Masson’s trichrome staining, Alcian blue ...
Tao Chen +3 more
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Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
Nature Communications, 2020 Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence.
Bo Zhao +11 more
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Patologìâ, 2019 The aim was to determine the features of the NO system status in the left ventricular myocardium in the rats with intermittent hypoxic hypobaric hypoxia during 15 and 60 days. Material and methods.
Yu. M. Kolesnyk +2 more
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