Results 21 to 30 of about 1,545,547 (221)

Metabolic Syndrome and Hypertension Resulting from Fructose Enriched Diet in Wistar Rats

BioMed Research International, 2017
Increased sugar consumption, especially fructose, is strongly related to the development of type 2 diabetes (T2D) and metabolic syndrome. The aim of this study was to evaluate long term effects of fructose supplementation on Wistar rats.
Julie Dupas, Annie Féray, C. Goanvec, A. Guernec, Nolwenn Samson, Pauline Bougaran, F. Guerrero, J. Mansourati   +7 more
semanticscholar   +1 more source

Corneal Mineralization in Wistar Hannover Rats

Journal of Toxicologic Pathology, 2013
We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHan(TM):WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histopathologically and ...
Sou Wada, Takuya Doi, Satomi Hashimoto, Yumi Wako, Junko Sato, Minoru Tsuchitani   +5 more
openaire   +4 more sources

Protective effect of curcumin on lead acetate-induced testicular toxicity in Wistar rats

Research in Pharmaceutical Sciences, 2017
In recent years, the use of the antioxidant in reducing heavy metal toxicities has increased worldwide. Curcumin has been reported to have a strong antioxidant activity.
S. Sudjarwo, G. W. Sudjarwo, Koerniasari
semanticscholar   +1 more source

Experimental model of heterotopic ossification in Wistar rats [PDF]

Brazilian Journal of Medical and Biological Research, 2012
Heterotopic ossification (HO) is a metaplastic biological process in which there is newly formed bone in soft tissues adjacent to large joints, resulting in joint mobility deficit. In order to determine which treatment techniques are more appropriate for such condition, experimental models of induced heterotopic bone formation have been proposed using ...
Zotz, T.G.G., Paula, J.B. de, Moser, A.D.L.   +2 more
openaire   +7 more sources

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Fenugreek seed extract attenuates cisplatin‐induced testicular damage in Wistar rats

Andrologia, 2016
Cisplatin (CIS) provides oxidative stress and inflammations in testicular tissues. Fenugreek seed extract (FSE) is a widely used herbal medicine with potent antioxidant and anti‐inflammation properties.
A. Hamza, H. Elwy, A. M. Badawi
semanticscholar   +1 more source

Machine Learning Guided Design of Nerve‐On‐A‐Chip Platforms with Promoted Neurite Outgrowth

Advanced Functional Materials, EarlyView.
Compared to labor‐intensive trial‐and‐error experimentation, a machine learning (ML)‐guided workflow, incorporating cell viability assays, data augmentation, ensemble modeling, and model interpretation, is developed to accelerate nerve‐on‐a‐chip optimization and uncover data‐driven design principles.
Tsai‐Chun Chung, Chu‐Chun Liang, Min‐Wei Huang, Tianle Chen, Joshua M. Little, Snehi Shrestha, Yi‐Chen Ethan Li, I‐Chi Lee, Po‐Yen Chen   +8 more
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Reservoir‐Type Subcutaneous Implantable Devices Containing Porous Rate Controlling Membranes for Sustained Delivery of Risperidone

Advanced Healthcare Materials, EarlyView.
This study presents a novel implantable drug delivery systemwith a biodegradable poly(caprolactone) membrane and compressed drug core forsustained release. These implantable devices deliver risperidone in vitro for 170 days and in vivo for 49 days in rats, showing promise for chronic conditions like schizophrenia.
Linlin Li, Andi Dian Permana, Juan Domínguez‐Robles, Muh Nur Amir, Habibie Habibie, Qonita Kurnia Anjani, Li Zhao, Natalia Moreno‐Castellanos, Ryan F Donnelly, Eneko Larrañeta   +9 more
wiley   +1 more source

Dilated cardiomyopathy in a wistar rat.

Journal of Toxicologic Pathology, 1995
A 57-week-old male Wistar rat died one week before the end of a toxicity study. Necropsy revealed subcutaneous edema, hydrothorax, dilatation of all cardiac chambers, and congestion in several organs. Light and electron microscopic examinations revealed myocardial hypertrophy, degeneration, fibrosis, and disruption of myofibrils and variable sized ...
Yoshimasa Okazaki, Osamu Katsuta, Junko Matsumoto, Minoru Tsuchitani   +3 more
openaire   +3 more sources