Results 291 to 300 of about 1,786,922 (333)

The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3/Caspase‐1 signaling pathway and oxidative stress in Wistar rats

Environmental Toxicology, 2021
The extensive existing of microplastics (MPs) in the ecosystem have increased considerable attention concerning their potential adverse effects, the toxicities and the underlying mechanism of MPs are still scarce.
Jialiu Wei, Xi-feng Wang, Qian Liu, Na Zhou, Shuxiang Zhu, Zekang Li, Xiaoli Li, Jinpeng Yao, Lianshuang Zhang   +8 more
semanticscholar   +1 more source

Wistar rat dermis recellularization

Research in Veterinary Science, 2020
Skin lesions are normal to all species, regardless of gender or age. The skin, the largest organ of the body, has function as a primary barrier to the chemical, physical and biological aggressions of the environment. In animals, these lesions may be due to fights and/or predations, also as in humans, there is a very common cause of dermal lesions that ...
A R, Martins, G S S, Matias, V F, Batista, M A, Miglino, P, Fratini   +4 more
openaire   +2 more sources

Neurotoxicity of heavy metals (aluminum chloride) studies performed on rats wistar

International Journal of Biosciences, 2019
Every day we are exposed to toxic heavy metals that pose a health risk, in an invisible way. All heavy metals are naturally present in trace amounts in our environment such as Aluminum chloride (AlCl3). Heavy metals are a metal element characterized by a

semanticscholar   +1 more source

Spontaneous Immunoglomerulonephritis in Wistar Rats

Pathology - Research and Practice, 1980
A strain of rats bred at the Nuclear Study Center of Mol (C.E.N.) develops a nephropathy characterized by granular deposition of immunoglobulin and complement in the renal glomeruli and tubules. We have attempted to specify the complement activation pathways (classical or alternate) in this disease by looking for their initial components (C1q, C3 and ...
A, Fridman-Manduzio, J, Salmon, E H, Betz   +2 more
openaire   +2 more sources

Acetaminophen nephrotoxicity in male Wistar rats

Archives of Toxicology, 1992
Acute acetaminophen (APAP) nephrotoxicity was studied in male Wistar rats 1 h after different APAP single doses (200, 500 and 1000 mg/kg body wt, i.p.). Significant impairments in glomerular filtration rate (GFR) and clearance of p-aminohippuric acid (ClPAH) were observed in a dose-dependent way, although tubular parameters measured, water and ...
L, Trumper, G, Girardi, M M, Elías
openaire   +2 more sources

Ameloblastoma in a female Wistar rat

Experimental and Toxicologic Pathology, 1995
A spontaneous ameloblastoma of the right mandible is described in a 120-week-old female Wistar rat (strain Chbb: THOM). The tumour had a locally aggressive growth pattern and was histologically characterized by sheets and islands of odontogenic epithelium bounded by a palisaded layer of ameloblast-like cells. Because of multifocal keratinizing squamous
H, Ernst, D, Mirea
openaire   +2 more sources

Endocardial Schwannomas in the Wistar Rat

Journal of Veterinary Medicine Series A, 2005
SummaryEndocardial neoplasms were observed in 13 Wistar rats, 15–30 months old, from a 30‐month inhalation study. Eight of the rats were dissected at 30 months and the other five between 15 and 29 months. Histologically, the lesions in the heart were diagnosed as endocardial schwannomas.
A, Teredesai, T, Wöhrmann
openaire   +2 more sources

Genotoxicity of nimesulide in Wistar rats

Drug and Chemical Toxicology, 2013
It is mandatory for all new drugs to be tested for their potential genotoxicity in addition to general toxicity testing. Some old drugs have not been tested adequately for their genotoxic effects because these were in use before the local regulations were enforced. According to the material safety database, the toxicological effect of nimesulide is not
Debojyoti, Borkotoky, Sushen K, Panda, Gyana R, Sahoo, Subas C, Parija   +3 more
openaire   +2 more sources

METABOLISM OF MYOSMINE IN WISTAR RATS

Drug Metabolism and Disposition, 2005
The alkaloid myosmine is present not only in tobacco products but also in various foods. Myosmine is easily nitrosated, yielding 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and the esophageal tobacco carcinogen N'-nitrosonornicotine. Due to its widespread occurrence, investigations on the metabolism and activation of myosmine are needed for risk ...
Wolfgang, Zwickenpflug, Stefan, Tyroller, Elmar, Richter   +2 more
openaire   +2 more sources

Lymphoproliferative lesions in BB Wistar rats

Metabolism, 1983
Fifteen percent of long-term diabetic BB Wistar rats developed abdominal B cell lymphoproliferative lesions which ranged from minute mesenteric aggregates of plasma cells and lymphocytes to malignant lymphoma with features of immunoblastic sarcoma or plasma-cell lymphoma.
T A, Seemayer, N, Kalant, W, Schürch, E, Colle   +3 more
openaire   +2 more sources