Oxidative Medicine and Cellular Longevity, 2019 N-Acetyl-p-aminophenol (APAP) or acetaminophen is the most common drug ingredient worldwide. It is found in more than 600 different over-the-counter and prescription medicines. Its long-term and overdose use is highly toxic and may result in liver injury.
O. Ahmed +7 more
semanticscholar +1 more source
Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of attention deficit hyperactivity disorder [PDF]
, 2015 Attention deficit hyperactivity disorder (ADHD) is associated with hypofunctional medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC). Methylphenidate (MPH) remediates ADHD, in part, by inhibiting the norepinephrine transporter (NET). MPH also
Dwoskin, Linda P. +2 more
core +4 more sources
Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3 [PDF]
, 2017 Background: We have previously confirmed the importance of rat chromosome 3 (RNO3) genetic loci on blood pressure elevation, pulse pressure (PP) variability and renal pathology during salt challenge in the stroke-prone spontaneously hypertensive (SHRSP ...
Beattie, Wendy +8 more
core +9 more sources
Medical Laboratory Journal, 2022 Background and objectives: Lead (Pb) is among the most toxic pollutants that affect health of both humans and animals. Finding a way to prevent Pb accumulation in animals’ bodies seems necessary.
Nahid Valipoor +3 more
doaj
Acta Medica, 1998 Plasma prolactin was measured in genetically hypertensive obese Koletsky rats, in their lean siblings and in normotensive rats of Wistar strain. Lean as well as obese females show hyperprolactinemia.
Věroslav Golda, Jana Jurčovičová
doaj +1 more source
A comparison of the results from intra-pleural and intra-peritoneal studies with those from inhalation and intratracheal tests for the assessment of pulmonary responses to inhalable dusts and fibres. [PDF]
, 2016 The aim of this paper is to compare results from inhalation studies with those from intraperitoneal and intrapleural tests, where available, for a number of fibrous and particulate test materials.
Bevan, Ruth +2 more
core +2 more sources
Chronic toxicity of low dose monosodium glutamate in albino Wistar rats
BMC Research Notes, 2019 The objective of this study was to observe the effects of chronic dosing with monosodium glutamate on mortality, fertility, major organ functions and histology in albino Wistar rats.
J. Nnadozie +7 more
semanticscholar +1 more source
A rat model of early stage osteonecrosis induced by glucocorticoids
Journal of Orthopaedic Surgery and Research, 2011 Background Glucocorticoid (GC)-induced osteonecrosis (ON) is an important complication of medical therapy. The exact pathomechanisms of ON has not been clearly elucidated.
Kerachian Mohammad +5 more
doaj +1 more source
Effect of dithiocarbamate thiram on Wistar rat growth plate and articular cartilage [PDF]
, 2012 Avaliou-se o efeito do tirame, ditiocarbamato largamente utilizado na agricultura como antifúngico e repelente de roedores, na ossificação endocondral de mamíferos, usando, como modelo, ratos Wistar.
Cabrita, AS +4 more
core +3 more sources
Age-related changes in hematological and biochemical profiles of Wistar rats
Laboratory Animal ResearchBackground Wistar rats are extensively used as the model for assessing toxicity and efficacy in preclinical research. Hematological and biochemical laboratory data are essential for evaluating specific variations in the physiological and functional ...
Suresh Patel +10 more
semanticscholar +1 more source