Results 71 to 80 of about 333,799 (287)

Protective effect of leukotriene receptor antagonist montelukast on smoking-induced lung injury in Wistar rats. [PDF]

, 2003
Increased activation of alveolar macrophage, neutrophil and mast cell has been proven in cigarette smoking (CS)-related lung disorders (CSLD). An increased production of cysteinyl-leukotrienes (LTs), which are mediators secreted from the mentioned cells,
Coskun, Senol, Ozbilgin, Kemal, Tuglu, Ibrahim, Yuksel, Hasan   +3 more
core   +1 more source

Inhalable Artificial Polymeric Nucleases Degrading Neutrophil Extracellular Trap‐DNAs and Alleviating Pulmonary Fibrosis

Advanced Science, EarlyView.
Pulmonary fibrosis (PF) is promoted by NETs that induce fibroblast activation. PEG‐PIm, a polymeric artificial DNase is reported that efficiently degrades NET‐DNA via phosphodiester bond hydrolysis. Inhalation of PEG‐PIm in a mouse PF model prevents fibroblast activation and fibrosis progression, offering a promising therapeutic strategy for NET ...
Yibo Du, Chenxu Zhu, Ruifeng Wang, Shi Chen, Chuang Li, Defang OuYang, Lixin Liu, Yongming Chen   +7 more
wiley   +1 more source

Isolation and Characterization of Ischemia-Derived Astrocytes (IDAs) with Ability to Transactivate Quiescent Astrocytes [PDF]

, 2016
Reactive gliosis involving activation and proliferation of astrocytes and microglia, is a widespread but largely complex and graded glial response to brain injury.
Barbeito, Osvaldo Luis, Cadena, María Vanesa, Dodes Traian, Martín Miguel, Murta, Verónica, Ramos, Alberto Javier, Rosciszewski, Gerardo Ariel, Setton, Clara Patricia, Usach, Vanina, Villarreal, Alejandro   +8 more
core   +1 more source

Mitochondria‐Targeted ROS Scavenging Natural Enzyme Cascade Nanogels for Periodontitis Treatment via Hypoxia Alleviation and Immunomodulation

Advanced Science, EarlyView.
TPP‐SAT, a mitochondria‐targeted natural enzyme‐cascade nanogel, selectively scavenges mitochondrial ROS (e.g., H2O2/·O2⁻) and converts them into therapeutic O2 via enzymatic cascades, alleviating hypoxia and inflammation. It rebalances M1/M2 macrophage polarization, activates the Nrf2 pathway while suppressing NF‐κB, enhances antioxidant defenses, and
Yanfen Zheng, Liuzhou Mao, Qi Wang, Haohua Hu, Bahriman Xarpidin, Zheng Luo, Yun‐Long Wu   +6 more
wiley   +1 more source

Stress-related alterations of visceral sensation: animal models for irritable bowel syndrome study. [PDF]

, 2011
Stressors of different psychological, physical or immune origin play a critical role in the pathophysiology of irritable bowel syndrome participating in symptoms onset, clinical presentation as well as treatment outcome.
Larauche, Muriel, Mulak, Agata, Taché, Yvette   +2 more
core   +2 more sources

Highly Efficient Classification of Time‐Series Based on Resistive Switching Cluster‐Assembled Materials

Advanced Intelligent Systems, EarlyView.
Cluster‐assembled nanocomposite devices are employed for the classification of neuronal traces, without any preprocessing of the input time‐series or prior training of the nonlinear devices. The classification method relies on the statistical analysis of the device's output time‐series, achieving higher classification accuracy compared to more energy ...
Filippo Profumo, Francesca Borghi, Tommaso Angì, Marta Maschietto, Stefano Vassanelli, Paolo Milani   +5 more
wiley   +1 more source

Trichosomoides crassicauda infection in wistar rats

Archives of Razi Institute, 2014
Laboratory animals, including rats, play an important role in biomedical research and advances. The human care and management of these animals is an ongoing concern.
Bahrami, S., , Rezaei, A., , Alborzi, A.R.   +2 more
doaj  

Biochemical characterisation of a Kunitz-type inhibitor from Tamarindus indica L. seeds and its efficacy in reducing plasma leptin in an experimental model of obesity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
A trypsin inhibitor isolated from tamarind seed (TTI) has satietogenic effects in animals, increasing the cholecystokinin (CCK) in eutrophy and reducing leptin in obesity. We purified TTI (pTTI), characterised, and observed its effect upon CCK and leptin
Amanda Fernandes de Medeiros, Izael de Sousa Costa, Fabiana Maria Coimbra de Carvalho, Sumika Kiyota, Beatriz Blenda Pinheiro de Souza, Daniel Nogoceke Sifuentes, Raphael Paschoal Serquiz, Bruna Leal Lima Maciel, Adriana Ferreira Uchôa, Elizeu Antunes dos Santos, Ana Heloneida de Araújo Morais   +10 more
doaj   +1 more source

Effect of Aqueous Extract of Blackberry Nightshade (Solanum nigrum) Leaf on Carbonated Alcoholic Herbal Beverage (CAHB)-Induced Cerebellar Damage and Behavioural Changes in Adult Wistar Rats

Journal of Applied Sciences and Environmental Management, 2019
This study was aimed at investigating the effect of aqueous extract of Solanum nigrum leaf on carbonated alcoholic herbal beverage-induced cerebellar damage and behavioural changes.
G.I Eze, C.O Ekechi, V.O Ekundina, K.A Akonoafua   +3 more
doaj   +1 more source

Animal models of cisplatin‐induced neuropathic pain

Animal Models and Experimental Medicine, EarlyView.
This article illustrates the modeling process of a cisplatin‐induced neuropathic pain model in rats or mice. Multiple modeling tests are required for rats or mice before, during, and after modeling. The appropriate injection method, dose, and modeling method are selected, and multiple assays are chosen for evaluation and comparison.
Ningxin Li, Mingzhu Li, Shengbo Jin, Jun Yu, Hongzhe Wei, Wenping Wang, Siyao Ma, Yuxin Jiang, Qian Liu, Huini Yao   +9 more
wiley   +1 more source