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Rat-Rat Hybridoma Formation and Rat Monoclonal Antibodies [PDF]
, 1987 The first model of monoclonal antibody-secreting hybridomas, developed by Kohler and Milstein (1), was a mouse system. It can be considered eminently successful, most likely because of its efficiency and extreme stability. If it is so successful, why develop another rodent model? There are, at least, three main reasons.
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2003
There is an increasing interest in the preparation of rat × rat hybridomas, because they have been found to be more stable in culture than mouse hybridomas and they secrete consistently high levels (10 µg/mL and above) of monoclonal antibody. In addition, certain subclasses of rat IgG have been found to interact efficiently with human Fc receptors and ...
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There is an increasing interest in the preparation of rat × rat hybridomas, because they have been found to be more stable in culture than mouse hybridomas and they secrete consistently high levels (10 µg/mL and above) of monoclonal antibody. In addition, certain subclasses of rat IgG have been found to interact efficiently with human Fc receptors and ...
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1996
One of the most important effects to control against in psychological experimentation is the effect of experimenter bias. Experimenters can all too easily find what they are looking for (support for their own hypotheses) by inadvertently influencing the way in which their subjects behave.
K. L. Fode, R. Rosenthal
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One of the most important effects to control against in psychological experimentation is the effect of experimenter bias. Experimenters can all too easily find what they are looking for (support for their own hypotheses) by inadvertently influencing the way in which their subjects behave.
K. L. Fode, R. Rosenthal
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Digestion, 1990
Four months of sigmoid colon intrinsic denervation of young male Wistar rats resulted in typical megacolon. Average 46.0% denervation of the Auerbach plexus was obtained by serosal application of benzalkonium chloride (0.2% v/v). Denervation was assessed by ganglion cell counts in a 480-nm extension of the treated segment.
J. S. M. Oliveira +2 more
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Four months of sigmoid colon intrinsic denervation of young male Wistar rats resulted in typical megacolon. Average 46.0% denervation of the Auerbach plexus was obtained by serosal application of benzalkonium chloride (0.2% v/v). Denervation was assessed by ganglion cell counts in a 480-nm extension of the treated segment.
J. S. M. Oliveira +2 more
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Archives of Oral Biology, 1965
Abstract To assess the contribution of the condyle to the growth of the mandible, forty-two Holtzman albino rats weighing between 40–50 g, were bilaterally condylectomized and at maturity compared anatomically and radiographicalry with 10 shamoperated and 27 control animals. From standardized lateral radiographs, the incisor overjet and molar overjet
C.F.A. Moorrees, A.A. Gianelly
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Abstract To assess the contribution of the condyle to the growth of the mandible, forty-two Holtzman albino rats weighing between 40–50 g, were bilaterally condylectomized and at maturity compared anatomically and radiographicalry with 10 shamoperated and 27 control animals. From standardized lateral radiographs, the incisor overjet and molar overjet
C.F.A. Moorrees, A.A. Gianelly
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Veterinary Clinics of North America: Exotic Animal Practice, 2010
The past decade has seen an increase in the number of rodents being kept as pets and subsequently in the number of rodent owners seeking veterinary services. The common rat, (Rattus norvegicus) has become increasingly popular, particularly as novel varieties have been introduced to the pet market.
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The past decade has seen an increase in the number of rodents being kept as pets and subsequently in the number of rodent owners seeking veterinary services. The common rat, (Rattus norvegicus) has become increasingly popular, particularly as novel varieties have been introduced to the pet market.
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Agents and Actions, 1988
Basic mechanisms of the rat ERG were reinvestigated with contemporary methods of recording and photic stimulation via an optic fiber system connected with a contact lens. Flash stimulation and background illuminance were performed with photometrically defined light stimuli.
X. Fink +4 more
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Basic mechanisms of the rat ERG were reinvestigated with contemporary methods of recording and photic stimulation via an optic fiber system connected with a contact lens. Flash stimulation and background illuminance were performed with photometrically defined light stimuli.
X. Fink +4 more
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British Veterinary Journal, 1975
SUMMARY Glaucoma in the rat is described. In Wistar rats buphthalmus was diagnosed. In strains of Sprague–Dawley rats the glaucomas were considered to be secondary, however, the causes were not easily determined. One case was associated with a tumour of the ciliary body; the others were in the main associated with intraocular inflammatory disease of ...
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SUMMARY Glaucoma in the rat is described. In Wistar rats buphthalmus was diagnosed. In strains of Sprague–Dawley rats the glaucomas were considered to be secondary, however, the causes were not easily determined. One case was associated with a tumour of the ciliary body; the others were in the main associated with intraocular inflammatory disease of ...
openaire +3 more sources