Results 111 to 120 of about 11,640,128 (328)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

PENENTUAN NILAI KALOR HIGH HEATING VALUE (HHV) DAN LOW HEATING VALUE (LHV) DARI MATERIAL SAMPAH COMBUSTIBLE ZONA AKTIF II TPA JATIBARANG SEMARANG [PDF]

open access: yes, 2017
Abstrak Peningkatan jumlah penduduk berdampak pada tingginya kebutuhan energi. Sehingga, sumber daya yang tersedia juga semakin berkurang dan perlu digantikan dengan sumber energi yang baru. Konsep waste to energy (WTE) dapat dijadikan alternatif untuk
Sembiring, Lucy Amena
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Evolution and characterization of eggshell as a potential candidate of raw material

open access: yesCerâmica, 2018
Characterization of both uncalcined and calcined eggshells was done in this work. Raw eggshells turned out as a good source of calcite phase. Calcined eggshells had a mixture of lime and portlandite phase.
T. Zaman   +3 more
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

A PRELIMINARY STUDY OF THE EFFECT OF ALTERATION ON BREAKAGE PROPERTIES OF ANDESITES FROM TÁLLYA AND RECSK (HUNGARY)

open access: yesRudarsko-geološko-naftni Zbornik
This preliminary study investigates the influence of post-magmatic alteration on the breakage behaviour of andesitic rocks during comminution, with particular emphasis on the Chemical Index of Alteration (CIA) and smectite content.
Izabella Rebeka Márkus   +2 more
doaj   +1 more source

Quality aspects of processed organic baby food - Results of a case study from an expert consultation in the baby food industry in 10 European countries. [PDF]

open access: yes, 2008
The processor survey shows the general principles and understanding of quality for the processing of organic food from the processors’ point of view.
Kretzschmar, Ursula   +2 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Plastic recycling and their use as raw material for the synthesis of carbonaceous materials

open access: yesHeliyon, 2022
R. A. Muñoz Meneses   +5 more
semanticscholar   +1 more source

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