Results 201 to 210 of about 458,842 (310)

Lactobacillus Salivarius‐Derived Indole‐3‐Acetic Acid Promotes AHR‐PARP1 Axis‐Mediated DNA Repair to Mitigate Intestinal Aging

open access: yesAdvanced Science, EarlyView.
Indole‐3‐acetic acid (IAA) acting as one of the aryl hydrocarbon receptor (AHR) endogenous ligands is identified to be derived from Lactobacillus salivarius via its catalytic enzyme (ALDH) rather than host cells. Lactobacillus salivarius and IAA supplementation effectively mitigate intestinal aging by facilitating AHR‐poly (ADP‐ribose) polymerase 1 ...
Zheng Cao   +13 more
wiley   +1 more source

Influence of Heat- and Cold-Stressed Raw Milk on the Stability of UHT Milk. [PDF]

open access: yesFoods
Li N   +12 more
europepmc   +1 more source

Boron Nitride Reinforced Supramolecular Gels Nano‐Assembled with Fungicides toward Soil‐Borne Fungal Disease Management

open access: yesAdvanced Science, EarlyView.
This work demonstrates of 2D material‐mediated stimuli‐responsive transport in soft matter systems, pioneers a new class of nano‐bridged carriers with mechanically strengthening and programmable permeability characteristics designed to overcome persistent barriers in soil‐borne disease management.
Li Hao   +9 more
wiley   +1 more source

Microbiological quality of raw milk: community expansion tanks in Alagoas [PDF]

open access: diamond
Karla Danielle Almeida Soares   +10 more
openalex   +1 more source

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels

open access: yesAdvanced Science, EarlyView.
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu   +10 more
wiley   +1 more source

12‐HETE Is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture

open access: yesAdvanced Science, EarlyView.
In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Yuyu Li   +13 more
wiley   +1 more source

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu   +10 more
wiley   +1 more source

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