Results 241 to 250 of about 2,785,182 (312)

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

The genome sequence of black currant, <i>Ribes nigrum</i> L. (Saxifragales: Grossulariaceae). [PDF]

Wellcome Open Res
Christenhusz MJM, Leitch IJ, Fay MF, Royal Botanic Gardens Kew Genome Acquisition Lab, Plant Genome Sizing Collective, Darwin Tree of Life Barcoding collective, Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team, Wellcome Sanger Institute Scientific Operations: Sequencing Operations, Wellcome Sanger Institute Tree of Life Core Informatics team, Tree of Life Core Informatics collective, Darwin Tree of Life Consortium.   +11 more
europepmc   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Genome sequencing and assembly for <i>Aspergillus ustus</i> VKPM-F2030. [PDF]

Microbiol Resour Announc
Popova E, Shestakova A, Lavrenova V, Shelukhanov E.   +3 more
europepmc   +1 more source

Chromosome level genome assembly and full-length transcriptome of blacktip trevally (Caranx heberi). [PDF]

Sci Data
Shekhar MS, Katneni VK, Prabhudas SK, Jangam AK, Selvaraj A, Jose IM, Krishnan K, Jani RJA.   +7 more
europepmc   +1 more source

Complete genome sequence of <i>Streptomyces diastaticus</i> strain GN02 and analysis of its biosynthetic gene clusters. [PDF]

Microbiol Resour Announc
González-Nava J, Elenes-Zazueta HJ, Marcos-Viquez J.   +2 more
europepmc   +1 more source

Complete genome sequences of the biocontrol strains <i>Bacillus velezensis</i> MRL14-522 and MRL14-108. [PDF]

Microbiol Resour Announc
Grimonpont M, Turc E, Monnier N, Bardin M.   +3 more
europepmc   +1 more source

Complete genome sequence of an MDR and hypermucoviscous <i>Klebsiella pneumoniae</i> strain KP99 isolated from a 62-year-old patient in Dalian, China. [PDF]

Microbiol Resour Announc
Fan F, Hao Y, Wang T, Gao Y, Chai P, Luo S, Song M, Wu Y, Wu C, Hao C, Yang Z.   +10 more
europepmc   +1 more source