PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source
Chromosome-scale genome assembly and annotation of Garuga floribunda var. gamblei (King ex W. W. Sm.) Kalkman. [PDF]
Chen R, Rao R, Yue LL.
europepmc +1 more source
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat +6 more
wiley +1 more source
Draft genome sequence of a novel species of <i>Winogradskyella</i> (strain PC D3.3) isolated from a Red Antarctic macroalgae. [PDF]
John J +5 more
europepmc +1 more source
A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol +18 more
wiley +1 more source
Whole-genome sequences of the dwarf honey bee subgenus Micrapis: Apis andreniformis and Apis florea. [PDF]
Ivancevic A +5 more
europepmc +1 more source
An amplicon-based tiled PCR scheme for the enrichment of avian metapneumovirus subtype B genomes prior to next generation sequencing. [PDF]
Álvarez-Narváez S +2 more
europepmc +1 more source
Complete genome sequence of the calcite-precipitating bacterium <i>Cytobacillus kochii</i> strain ITBMC_116, isolated from a limestone karst in Vietnam. [PDF]
Vu TM +7 more
europepmc +1 more source
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