Results 51 to 60 of about 22,141 (218)

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC‐Derived Microglia and Modulates Glial‐Neuronal Crosstalk

Glia, Volume 74, Issue 1, January 2026.
C9orf72 microglia display heightened glycolysis and oxidative stress, driving astrocytic reprogramming that impacts motor neurons. iPSC tricultures uncover key glial–neuronal interactions in C9orf72 pathology. ABSTRACT The C9orf72 hexanucleotide repeat expansion mutation is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and ...
Marika Mearelli, Insa Hirschberg, Christin Weissleder, Carmela Giachino, María José Pérez, Malvina Dubroux, Francesca Provenzano, Mafalda Rizzuti, Linda Ottoboni, Udit Sheth, Tania F. Gendron, Stefania Corti, Michela Deleidi   +12 more
wiley   +1 more source

Cognitive profiles at presentation and subsequent cognitive decline and quality of life in Parkinson's disease

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Currently, our ability to predict cognitive decline in Parkinson's disease is limited. METHODS In 234 dementia‐free PD patients, cognitive profiles at baseline were determined using cluster analysis and longitudinal associations with global cognitive z‐score, health‐related quality of life (HR‐QoL), caregiver burden, and risk of ...
Saira S. Mirza, Sarah Duff‐Canning, Mark Mapstone, Susan Fox, Sandra E. Black, Malcolm A. Binns, David P. Breen, Keera N. Fishman, David A. Grimes, Anthony E. Lang, Brian Levine, Paula M. McLaughlin, Angela K. Troyer, Mario Masellis, Connie Marras   +14 more
wiley   +1 more source

On the Emergence of the Castellieri Settlements and Possible Effects of Climatic Changes in the 2nd Millennium BC in the Adriatic Region

Quaternary
The fortified hilltop settlement of Monkodonja, located near Rovinj on the west coast of Istria, Croatia, provides insight into Bronze Age occupation and conflict in the Adriatic region.
Anja Hellmuth Kramberger
doaj   +1 more source

Locus coeruleus‐entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Pretangle tau inclusions from the locus coeruleus (LC) are hypothesized to propagate to the entorhinal cortex (EC) via neuron‐to‐neuron transmission along its projections. The lower integrity of the LC‐EC pathway accompanying Alzheimer's disease (AD) pathology is supported by post mortem studies, but in vivo evidence remains ...
Yuliya Patsyuk, Maxime Van Egroo, Elise Beckers, Elouise A. Koops, Nicholas J. Ashton, Shorena Janelidze, Kaj Blennow, Oskar Hansson, Henrik Zetterberg, Benedikt A. Poser, Heidi I. L. Jacobs   +10 more
wiley   +1 more source

Mountain as an Archetype of »the Supreme« in Magomet H. Mokaev’s Work

Slavistična Revija
The article is the first attempt to study the mythologeme “mountain” in the works of the Karachay-Balkar writer Magomet Kh. Mokaev. The goal is to identify the functional features of the mythologeme as one of the dominants of the text structure in the ...
Rauzat Kerimova
doaj   +1 more source

Detection of TDP‐43 seeds in CSF of presymptomatic and symptomatic genetic FTD/ALS

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Seed amplification assays (SAAs) have shown promising results in detecting misfolded transactive response (TAR) DNA‐binding protein 43 (TDP‐43) in cerebrospinal fluid (CSF) of genetic frontotemporal dementia (FTD). To date, the use of SAA has yet to be evaluated in presymptomatic individuals.
Ilaria Linda Dellarole, Vittoria Aprea, Marcella Catania, Claudia Battipaglia, Aurora Romeo, Cristina Villa, Anna Burato, Luigi Celauro, Eleonora Dalla Bella, Nilo Riva, Erika Salvi, Giacomina Rossi, Giuseppe Di Fede, Giuseppe Legname, Julie F H De Houwer, Antonella Alberici, Barbara Borroni, Harro Seelaar, John C van Swieten, Fabio Moda, Paola Caroppo   +20 more
wiley   +1 more source

Beta Power Response After Levodopa Intake in Parkinson's Disease Patients With Chronic Sensing‐Enabled Deep Brain Stimulation

Annals of Neurology, Volume 98, Issue 6, Page 1352-1363, December 2025.
Objective In Parkinson's disease (PD), the power of beta oscillations (± 13–30 hertz [Hz]) from subthalamic nucleus (STN) local field potentials (LFPs) is associated with motor symptoms. Beta power can be used for adaptive deep brain stimulation (aDBS) algorithms based upon symptom fluctuations.
Martijn G.J. de Neeling, Bart J. Keulen, Mariëlle J. Stam, Deborah Hubers, Rob M.A. de Bie, Bernadette C.M. van Wijk, P. Rick Schuurman, Arthur W.G. Buijink, Martijn Beudel   +8 more
wiley   +1 more source

Estimation of sodium availability in food in Slovenia: results from household food purchase data from 2000 to 2009

Slovenian Journal of Public Health, 2014
Uvod: Glavni namen raziskave je bil ugotoviti razpoložljivost natrija v kupljenih živilih v Sloveniji. Osnovo so predstavljali podatki nacionalne raziskave o porabi v gospodinjstvih za obdobje 2000-2009. Sekundarni cilj raziskave je bil ugotoviti, katere
Ribič Cirila Hlastan, Zakotnik Jožica Maučec, Seljak Barbara Koroušić, Poličnik Rok, Blaznik Urška, Mis Nataša Fidler, Eržen Ivan, Ji Chen, Cappucio Francesco P.   +8 more
doaj   +1 more source

The Risk of Transmission of Genetic Prion Diseases is Greater Than 50%

European Journal of Neurology, Volume 32, Issue 12, December 2025.
This study investigated whether transmission ratio distortion (TRD) occurs in inherited prion diseases, specifically familial Creutzfeldt‐Jakob disease (p.E200K variant) and fatal familial insomnia (p.D178N variant), despite the theoretical 50% autosomal dominant inheritance risk.
Izaro Kortazar‐Zubizarreta, Africa Manero‐Azua, Hasier Eraña, Urko Aguire, Joaquín Castilla, Guiomar Perez de Nanclares   +5 more
wiley   +1 more source

Vsakdan in gibanje, 2012

, 2012
Glavni namen raziskave Vsakdan in gibanje je prepoznati odnos do telesne oz. športne aktivnosti respondentov in v tej povezavi nadalje tudi njihov odnos do posameznih ukrepov za njihovo spodbujanje.
Kustec Lipicer, Simona
core   +1 more source