Results 41 to 50 of about 199,364 (50)

High expression of G-protein signaling modulator 2 in hepatocellular carcinoma facilitates tumor growth and metastasis by activating the PI3K/AKT signaling pathway

Tumor Biology, 2017
The aim of this study was to investigate the role of G-protein signaling modulator 2 in the carcinogenesis and progression of hepatocellular carcinoma. We previously showed that G-protein signaling modulator 2 was upregulated in hepatitis B virus-related
Xiao-Qin He, Yue-Feng Zhang, Jia-Jun Yu, Yuan-Yuan Gan, Na-Na Han, Mei-Xia Zhang, Wei Ge, Jun-Jian Deng, Yong-Fa Zheng, Xi-Ming Xu   +9 more
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Drugging the ‘undruggable’ KRAS: breakthroughs, challenges, and opportunities in pancreatic cancer

Cancer Biology & Medicine
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis that is driven primarily by oncogenic KRAS mutations present in > 90% of cases.
Nawaz Khan, Umar Raza, Syed Aqib Ali Zaidi, Muhadaisi Nuer, Kayisaier Abudurousuli, Yipaerguli Paerhati, Alifeiye Aikebaier, Wenting Zhou   +7 more
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Knockdown of long non-coding RNA HOXD-AS1 inhibits gastric cancer cell growth via inactivating the JAK2/STAT3 pathway

Tumor Biology, 2017
Long non-coding RNA HOXD-AS1 (HOXD cluster antisense RNA 1) has been demonstrated to be closely associated with the progression of several tumors. However, the biological function of HOXD-AS1 and the underlying molecular mechanism in gastric cancer are ...
Li Zheng, Jiangtao Chen, Zhongyong Zhou, Zhikuan He   +3 more
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Lactate and lactylation in breast cancer: current understanding and therapeutic opportunities

Cancer Biology & Medicine
Breast cancer (BC) has the highest prevalence among cancers specific to women, and its incidence rates are increasing in many countries. Subtypes of BC, including HER2-positive or triple-negative BC, exhibit differing treatment responses; consequently ...
Lan Huang, Xuemei Chen, Meina Yan, Ze Xiang, Jian Wu   +4 more
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Silencing of bach1 gene by small interfering RNA–mediation regulates invasive and expression level of miR-203, miR-145, matrix metalloproteinase-9, and CXCR4 receptor in MDA-MB-468 breast cancer cells

Tumor Biology, 2017
Background: Recently experimental validation of the networks revealed bach1, a basic leucine zipper transcription factor, as the common regulator of several functional invasive genes.
Reza Mohammadzadeh, Mojgan Saeid Harouyan, Seyed Mansour Ale Taha   +2 more
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The polarity protein Par3 enhances renal cell carcinoma metastasis via YAP/TAZ activation

Cancer Biology & Medicine
Objective: Partitioning defective protein 3 (Par3) has recently been found to have important roles in cancer progression. Interestingly, Par3’s functions vary among cancers: both Par3 elevation (in the prostate or liver) and loss (in the breast or lung ...
Soo Lee, Jonathan Balcazar, Karla Davis, Rey-Chen Pong, Jer-Tsong Hsieh, Payal Kapur, Xiaosong Meng   +6 more
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Abstracts of invited lectures and oral presentations at ISOBM 2017

Tumor Biology, 2018
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Correction

Cancer Biology & Therapy
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Correction: Prospective evaluation of artificial intelligence (AI) applications for use in cancer pathways following diagnosis: a systematic review

BMJ Oncology
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Non-essential role of S100A9 in hematopoiesis in primary MPN and MDS mouse models

Cancer Biology & Medicine
Qinglin Li, Xuezhen Ma, Zhaofeng Li, Xinshu Xie, Yating Lu, Hanqi Liu, Ailing Zou, Yexin Yang, Jie Ouyang, Shuqian Xu, Yang Mei   +10 more
doaj   +1 more source