Results 1 to 10 of about 142,570 (53)

Novel EAAT2 activators improve motor and cognitive impairment in a transgenic model of Huntington’s disease

Frontiers in Behavioral Neuroscience, 2023
IntroductionGlutamate excitotoxicity is causal in striatal neurodegeneration underlying motor dysfunction and cognitive deficits in Huntington’s disease (HD).
Akanksha Bhatnagar, Visha Parmar, Visha Parmar, Nicholas Barbieri, Nicholas Barbieri, Frank Bearoff, Felice Elefant, Sandhya Kortagere   +7 more
doaj   +1 more source

Information-theoretic analysis of Hierarchical Temporal Memory-Spatial Pooler algorithm with a new upper bound for the standard information bottleneck method

Frontiers in Computational Neuroscience, 2023
Hierarchical Temporal Memory (HTM) is an unsupervised algorithm in machine learning. It models several fundamental neocortical computational principles.
Shiva Sanati, Modjtaba Rouhani, Ghosheh Abed Hodtani   +2 more
doaj   +1 more source

OPRM1 A118G polymorphism modulating motor pathway for pain adaptability in women with primary dysmenorrhea

Frontiers in Neuroscience, 2023
IntroductionPrimary dysmenorrhea (PDM) is a common condition among women of reproductive age, characterized by menstrual pain in the absence of any organic causes.
Pei-Shan Hsu, Pei-Shan Hsu, Pei-Shan Hsu, Chou-Ming Cheng, Hsiang-Tai Chao, Ming-Wei Lin, Wei-Chi Li, Wei-Chi Li, Wei-Chi Li, Lin-Chien Lee, Lin-Chien Lee, Lin-Chien Lee, Ching-Hsiung Liu, Ching-Hsiung Liu, Li-Fen Chen, Li-Fen Chen, Li-Fen Chen, Li-Fen Chen, Jen-Chuen Hsieh, Jen-Chuen Hsieh, Jen-Chuen Hsieh, Jen-Chuen Hsieh   +21 more
doaj   +1 more source

Assessment of precision and reliability of a novel computerized heterophoria test

Frontiers in Neuroscience, 2023
PurposeTo assess the precision and reliability of a novel computerized heterophoria test (CHT).MethodsOne hundred and three subjects aged 20 to 48 (27.37 ± 5.15) were recruited from Wenzhou Medical University.
Yuwen Wang, Yuwen Wang, Fuhao Zheng, Fengchao Zhou, E. Song   +4 more
doaj   +1 more source

Initial severity of the Positive and Negative Syndrome Scale (PANSS)-30, its main subscales plus the PANSS-6, and the relationship to subsequent improvement and trial dropout: a pooled participant-level analysis of 18 placebo-controlled risperidone and paliperidone trials

Translational Psychiatry, 2023
Greater initial severity on the 30-item Positive and Negative Syndrome Scale (PANSS-30) correlates positively with antipsychotic-placebo separation and trial dropout, but it is unknown whether these associations are present also on PANSS-derived ...
Fredrik Hieronymus, Christoph Ulrich Correll, Søren Dinesen Østergaard   +2 more
doaj   +1 more source

Effectiveness of non-pharmacological traditional Chinese medicine combined with conventional therapy in treating fibromyalgia: a systematic review and meta-analysis

Frontiers in Neuroscience, 2023
ObjectiveFibromyalgia is a chronic musculoskeletal disorder characterized by generalized pain, which is also known as “muscular rheumatism” in Chinese medicine.
Lili Cai, Lili Cai, Zhengquan Chen, Juping Liang, Yuanyuan Song, Hong Yu, Jiaye Zhu, Qikai Wu, Xuan Zhou, Qing Du, Qing Du   +10 more
doaj   +1 more source

Pre-intensive care unit use of selective serotonin reuptake inhibitors and mortality in critically ill adults with mental disorders: analysis from the MIMIC-IV database

Translational Psychiatry, 2023
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed drugs for mental disorders in critically ill patients. We performed a retrospective cohort study to investigate the association between pre-ICU use of SSRIs and mortality in
Wan-Jie Gu, Lu-Ming Zhang, Chun-Mei Wang, Feng-Zhi Zhao, Hai-Yan Yin, Jun Lyu   +5 more
doaj   +1 more source

Cisplatin ototoxicity mechanism and antagonistic intervention strategy: a scope review

Frontiers in Cellular Neuroscience, 2023
Cisplatin is a first-line chemotherapeutic agent in the treatment of malignant tumors with remarkable clinical effects and low cost. However, the ototoxicity and neurotoxicity of cisplatin greatly limit its clinical application.
Yingru Li, Yingru Li, Yingru Li, Tianyang Zhang, Tianyang Zhang, Tianyang Zhang, Qiang Song, Qiang Song, Qiang Song, Dekun Gao, Dekun Gao, Dekun Gao, Yue Li, Yue Li, Yue Li, Huiqun Jie, Huiqun Jie, Huiqun Jie, Ping Huang, Ping Huang, Ping Huang, Guiliang Zheng, Guiliang Zheng, Guiliang Zheng, Jun Yang, Jun Yang, Jun Yang, Jingchun He, Jingchun He, Jingchun He   +29 more
doaj   +1 more source

Short-term plasticity of the motor cortex compensates for bradykinesia in Parkinson’s disease

Neurobiology of Disease, 2023
Patients with Parkinson's disease (PD) show impaired short-term potentiation (STP) mechanisms in the primary motor cortex (M1). However, the role played by this neurophysiological abnormality in bradykinesia pathophysiology is unknown.
Andrea Guerra, Donato Colella, Antonio Cannavacciuolo, Margherita Giangrosso, Giulia Paparella, Giovanni Fabbrini, Alfredo Berardelli, Matteo Bologna   +7 more
doaj   +1 more source

Super-resolution imaging pinpoints the periodic ultrastructure at the human node of Ranvier and its disruption in patients with polyneuropathy

Neurobiology of Disease, 2023
The node of Ranvier is the key element in saltatory conduction along myelinated axons, but its specific protein organization remains elusive in the human species.
Luise Appeltshauser, Janis Linke, Hannah S. Heil, Christine Karus, Joachim Schenk, Katherina Hemmen, Claudia Sommer, Kathrin Doppler, Katrin G. Heinze   +8 more
doaj   +1 more source