Results 1 to 10 of about 169,093 (102)

Implementasi Standar Audit (SA) 701: Pengomunikasian Hal Audit Utama di Tahun Pertama Penerapan

Jurnal Akuntansi Manado (JAIM), 2023
Penelitian ini bertujuan untuk menganalisis bagaimana implementasi SA 701 dan apa saja kendala yang dihadapi auditor dalam implementasi SA 701 di tahun pertama penerapannya.
Marina Lauren, Aria Farah Mita
semanticscholar   +1 more source

Multi-institutional retrospective study investigating blood culture protocols and test positivity in 701 dogs

Frontiers in Veterinary Science, 2023
Objectives (i) To determine the influence of specimen collection protocol (timing and specimen quantity), primary disease process, and pre-existing antimicrobial or immunosuppressive therapy on blood culture (BC) positivity and (ii) To determine ...
Andrzej J. Ogrodny, Rinosh Mani, Sarah M Schmid, Emily N Gould, C. Fellman, Ian M DeStefano, S. Shropshire, Jillian M. Haines, T. Bolton, Sara A Jablonski, Nicole Jess, H. Cridge   +11 more
semanticscholar   +1 more source

INZ‐701, a recombinant ENPP1 enzyme, prevents ectopic calcification in an Abcc6−/− mouse model of pseudoxanthoma elasticum

Experimental Dermatology, 2022
Pseudoxanthoma elasticum (PXE), a heritable multisystem ectopic calcification disorder, is predominantly caused by inactivating mutations in ABCC6. The encoded protein, ABCC6, is a hepatic efflux transporter and a key regulator of extracellular inorganic
I. Jacobs, Zhiliang Cheng, D. Ralph, K. O’Brien, Lisa Flaman, J. Howe, David Thompson, J. Uitto, Qiaoli Li, Y. Sabbagh   +9 more
semanticscholar   +1 more source

Efficacy and safety of a new ranibizumab biosimilar CKD-701 using a pro re nata treatment regimen in neovascular age-related macular degeneration: A phase 3 randomized clinical trial

PLoS ONE, 2022
Purpose This study aimed to establish the efficacy, safety, and immunogenicity equivalence of the proposed biosimilar CKD-701 with the reference ranibizumab in patients with treatment-naïve neovascular age-related macular degeneration (nAMD).
C. Yoon, Jaeryung Oh, K. Bae, Un Chul Park, K. Yu, H. Yu   +5 more
semanticscholar   +1 more source

INZ‐701 Prevents Ectopic Tissue Calcification and Restores Bone Architecture and Growth in ENPP1‐Deficient Mice

Journal of Bone and Mineral Research, 2021
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is the major enzyme that cleaves extracellular adenosine triphosphate (ATP) to generate pyrophosphate (PPi), an inorganic metabolite with potent anticalcification activity.
Zhiliang Cheng, K. O’Brien, J. Howe, C. Sullivan, D. Schrier, A. Lynch, S. Jungles, Y. Sabbagh, D. Thompson   +8 more
semanticscholar   +1 more source

Clinical profile and predictors of poor prognosis in infective endocarditis

Journal of Clinical and Preventive Cardiology, 2023
Context: Infective endocarditis (IE) is associated with high morbidity and mortality despite advances in diagnosis and treatment. A recent knowledge of the epidemiology and clinical spectrum of IE is essential for prompt recognition and effective therapy.
Bejoy V Ealias, Jayaprasad Narayanapillai, Suresh Madhavan, V L Jayaprakash, R Baiju   +4 more
doaj   +1 more source

Factor XI inhibitors in adjunct to antiplatelet therapy: the ultimate dual-pathway inhibition?

Bleeding, Thrombosis and Vascular Biology, 2023
A strategy of oral anticoagulants (OAC) in addition to single or dual antiplatelet therapy, known as dual-pathway inhibition (DPI), has shown to reduce thrombotic events in patients with cardiovascular disease.
Mattia Galli, C. Michael Gibson, Dominick J. Angiolillo   +2 more
doaj   +1 more source

Addressing some challenges of congenital fibrinogen disorders in 2023 and beyond

Bleeding, Thrombosis and Vascular Biology, 2023
Congenital fibrinogen disorders (CFD) include several types and subtypes of fibrinogen deficiency, resulting from monoallelic or biallelic mutations in one of the three fibrinogen genes. While it is relatively easy to make an accurate diagnosis based on
Cristina Santoro, Alessandro Casini
doaj   +1 more source

Cytokine pattern in patients with ST-elevation myocardial infarction treated with the interleukin-6 receptor antagonist tocilizumab

Open Heart, 2023
Background Tocilizumab improves myocardial salvage index (MSI) in patients with ST-elevation myocardial infarction (STEMI), but its mechanisms of action are unclear. Here, we explored how cytokines were affected by tocilizumab and their correlations with
Ola Kleveland, Rune Wiseth, Jan Kristian Damås, Pål Aukrust, Lars Gullestad, Bente Halvorsen, Einar Hopp, Kaspar Broch, T Ueland, Anne Kristine Anstensrud, Sindre Woxholt, Bjørn Bendz, Brage H Amundsen, Nils-Einar Kløw, Ingebjørg Seljeflot, Geir Øystein Andersen, Ingvild Maria Tøllefsen, Liv Ryan, Tuva B Dahl, Camilla Huse   +19 more
doaj   +1 more source

EVT‐701 is a novel selective and safe mitochondrial complex 1 inhibitor with potent anti‐tumor activity in models of solid cancers

Pharmacology Research & Perspectives, 2021
Targeting the first protein complex of the mitochondrial electron transport chain (MC1) in cancer has become an attractive therapeutic approach in the recent years, given the metabolic vulnerabilities of cancer cells. The anticancer effect exerted by the
Raquel Luna Yolba, V. Visentin, C. Hervé, J. Chiche, J. Ricci, J. Méneyrol, Michael R Paillasse, N. Alet   +7 more
semanticscholar   +1 more source