Results 1 to 10 of about 155,452 (97)

Implementasi Standar Audit (SA) 701: Pengomunikasian Hal Audit Utama di Tahun Pertama Penerapan

Jurnal Akuntansi Manado (JAIM), 2023
Penelitian ini bertujuan untuk menganalisis bagaimana implementasi SA 701 dan apa saja kendala yang dihadapi auditor dalam implementasi SA 701 di tahun pertama penerapannya.
Marina Lauren, Aria Farah Mita
semanticscholar   +1 more source

Efficacy and safety of a new ranibizumab biosimilar CKD-701 using a pro re nata treatment regimen in neovascular age-related macular degeneration: A phase 3 randomized clinical trial

PLoS ONE, 2022
Purpose This study aimed to establish the efficacy, safety, and immunogenicity equivalence of the proposed biosimilar CKD-701 with the reference ranibizumab in patients with treatment-naïve neovascular age-related macular degeneration (nAMD).
C. Yoon, Jaeryung Oh, K. Bae, Un Chul Park, K. Yu, H. Yu   +5 more
semanticscholar   +1 more source

INZ‐701, a recombinant ENPP1 enzyme, prevents ectopic calcification in an Abcc6−/− mouse model of pseudoxanthoma elasticum

Experimental Dermatology, 2022
Pseudoxanthoma elasticum (PXE), a heritable multisystem ectopic calcification disorder, is predominantly caused by inactivating mutations in ABCC6. The encoded protein, ABCC6, is a hepatic efflux transporter and a key regulator of extracellular inorganic
I. Jacobs, Zhiliang Cheng, D. Ralph, K. O’Brien, Lisa Flaman, J. Howe, David Thompson, J. Uitto, Qiaoli Li, Y. Sabbagh   +9 more
semanticscholar   +1 more source

INZ‐701 Prevents Ectopic Tissue Calcification and Restores Bone Architecture and Growth in ENPP1‐Deficient Mice

Journal of Bone and Mineral Research, 2021
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is the major enzyme that cleaves extracellular adenosine triphosphate (ATP) to generate pyrophosphate (PPi), an inorganic metabolite with potent anticalcification activity.
Zhiliang Cheng, K. O’Brien, J. Howe, C. Sullivan, D. Schrier, A. Lynch, S. Jungles, Y. Sabbagh, D. Thompson   +8 more
semanticscholar   +1 more source

EVT‐701 is a novel selective and safe mitochondrial complex 1 inhibitor with potent anti‐tumor activity in models of solid cancers

Pharmacology Research & Perspectives, 2021
Targeting the first protein complex of the mitochondrial electron transport chain (MC1) in cancer has become an attractive therapeutic approach in the recent years, given the metabolic vulnerabilities of cancer cells. The anticancer effect exerted by the
Raquel Luna Yolba, V. Visentin, C. Hervé, J. Chiche, J. Ricci, J. Méneyrol, Michael R Paillasse, N. Alet   +7 more
semanticscholar   +1 more source

Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis

Frontiers in Cardiovascular Medicine, 2022
Lipoprotein(a) (Lp[a]) blood levels >50 mg/dL is a major cardiovascular disease risk factor in humans. Lp(a) associates with increased cardiovascular calcification, a critical pathology with no clinically available drug therapies.
Maximillian A. Rogers, Samantha K. Atkins, Kang H. Zheng, Kang H. Zheng, Sasha A. Singh, Sarvesh Chelvanambi, Tan H. Pham, Shiori Kuraoka, Erik S. G. Stroes, Masanori Aikawa, Masanori Aikawa, Elena Aikawa, Elena Aikawa   +12 more
doaj   +1 more source

The immunomodulatory drugs lenalidomide and pomalidomide enhance the potency of AMG 701 in multiple myeloma preclinical models.

Blood Advances, 2020
We investigated here the novel immunomodulation and anti-multiple myeloma (MM) function of T cells engaged by the bispecific T-cell engager molecule AMG 701, and further examined the impact of AMG 701 in combination with immunomodulatory drugs (IMiDs ...
Shih-Feng Cho, Liang Lin, Lijie Xing, Yuyin Li, Kenneth Wen, Tengteng Yu, Phillip A. Hsieh, N. Munshi, J. Wahl, Katja Matthes, M. Friedrich, T. Arvedson, K. Anderson, Y. Tai   +13 more
semanticscholar   +1 more source

Massive hemoptysis treated with embolization of an ectopic bronchial artery arising from the right thyrocervical trunk: a case report

CVIR Endovascular, 2022
Background Ectopic bronchial artery and non-bronchial systemic arteries may be the culprit vessels of hemoptysis. The main cause of clinical failure of bronchial artery embolization is incomplete embolization caused by the misidentification of the ...
Songhyon Cho, Kenji Kubota, Yoshikazu Hirose, Norihiko Yoshimura, Yui Murai, Yasuo Hirose   +5 more
doaj   +1 more source

Current State and Future Directions of Multimodality Imaging in Cardiac Sarcoidosis

Frontiers in Cardiovascular Medicine, 2022
Cardiac sarcoidosis (CS) is an increasingly recognized cause of heart failure and arrhythmia. Historically challenging to identify, particularly in the absence of extracardiac sarcoidosis, diagnosis of CS has improved with advancements in cardiac imaging.
Alison L. Wand, Jonathan Chrispin, Elie Saad, Monica Mukherjee, Allison G. Hays, Nisha A. Gilotra   +5 more
doaj   +1 more source

A Phase 1 First in Human (FIH) Study of AMG 701, an Anti-B-Cell Maturation Antigen (BCMA) Half-Life Extended (HLE) BiTE® (bispecific T-cell engager) Molecule, in Relapsed/Refractory (RR) Multiple Myeloma (MM)

, 2020
Aims: To evaluate AMG 701, a BiTE® molecule binding BCMA on MM cells and CD3 on T cells, in RR MM (Amgen, NCT03287908); primary objective was to evaluate safety and tolerability and estimate a biologically active dose; secondary objectives were to ...
S. Harrison, M. Minnema, Hans C. Lee, A. Spencer, P. Kapoor, D. Madduri, J. Larsen, S. Ailawadhi, J. Kaufman, M. Raab, P. Hari, S. Iida, R. Vij, F. Davies, R. Lesley, V. Upreti, Zhao Yang, Anjali Sharma, A. Minella, S. Lentzsch   +19 more
semanticscholar   +1 more source