Results 81 to 90 of about 177,998 (114)

Abstract 1262: BLU-701 is a highly potent, brain-penetrant and WT-sparing next-generation EGFR TKI for the treatment of sensitizing (ex19del, L858R) and C797S resistance mutations in metastatic NSCLC

Experimental and Molecular Therapeutics, 2021
BACKGROUND: Non-small cell lung cancer (NSCLC) represents 80% of lung cancers, the second leading cause of cancer deaths globally. Mutations in the kinase domain of the epidermal growth factor receptor (EGFR) are genomic drivers in a molecular sub-type ...
C. Conti, John L. Campbell, R. Woessner, Jian Guo, Y. Timsit, M. Iliou, Scott D. Wardwell, A. Davis, Sharon Chicklas, J. Hsieh, Meredith S Eno, Omar Ahmad, D. Fernando, Kevin A Barvian, Joseph L. Kim, S. Kazmirski, E. Perola, T. Dineen, Victoria Brown, T. Guzi, Ayşegül Özen, F. Stevison, C. Utt, Clare Medendorp, R. Meissner, M. Dorsch, K. Hoeflich   +26 more
semanticscholar   +1 more source

The direct effect of the international standard on auditing – 701 requirements on audit profession concerning the reimbursement costs: case study of Jordanian finance industry

Asian Journal of Accounting Research
PurposeThe objective of this study is to present novel evidence regarding the impact of the Key Audit Matters (KAM) disclosure requirements of International Standard on Auditing – 701 (ISA) on the auditing profession concerning reimbursement costs in ...
Esraa
exaly   +2 more sources

LncRNA KCNQ1OT1 accelerates fracture healing via modulating miR‐701‐3p/FGFR3 axis

The FASEB Journal, 2020
Emerging evidence highlights the role of the long noncoding RNA (lncRNA) KCNQ1OT1 in fracture healing. Osteoblast proliferation, migration, and survival are pivotal during this process.
Lang Chen, Y. Xiong, Chenchen Yan, Wu Zhou, Y. Endo, Hang Xue, Yiqiang Hu, Liangcong Hu, Xingzhu Leng, Jing Liu, Ze Lin, B. Mi, Guohui Liu   +12 more
semanticscholar   +1 more source

Clinical and epidemiological characteristics of childhood vitiligo: a study of 701 patients from Brazil

International Journal of Dermatology, 2020
Vitiligo is an acquired pigmentary disorder that affects approximately 0.5–2% of the world's population, and 25% of cases begin before 10 years of age. Although prevalent, there are few studies on the characterization of childhood vitiligo.
Clarissa P.S. Martins, A. Hertz, P. Luzio, P. Paludo, L. Azulay‐Abulafia   +4 more
semanticscholar   +1 more source

Clinical update related to the first-in-human trial of SYS6002 (CRB-701), a next-generation nectin-4 targeting antibody drug conjugate.

Journal of Clinical Oncology
3151 Background: SYS6002 (CRB-701) is a novel, nectin-4 targeting antibody drug conjugate (ADC) that take advantage of a third generation, site-specific cleavable linker with novel conjugation chemistry.
D. Ye, Jian Zhang, Hua Yang, Jin Yang, Tongsen Zheng, Hongmei Sun, Yuping Sun, Guiling Li, Funan Liu, Xuechao Wan, Lan Ge, G. Sun, Xiao Zhang, Lei Wang, R. Brake   +14 more
semanticscholar   +1 more source

Phase 1 dose escalation of SYS6002 (CRB-701), a next-generation nectin-4 targeting antibody drug conjugate (ADC).

Journal of Clinical Oncology
622 Background: Linker-conjugation of an ADC is a key feature in optimizing highly active and well tolerated agents. For maximal intra-tumoral delivery, linkers need to be highly stable in the systemic circulation yet allow for efficient drug release at ...
D. Ye, Jian Zhang, Hua Yang, Jin Yang, Tongsen Zheng, Hongmei Sun, Xuechao Wan, G. Lan, G. Sun, Xiao Zhang   +9 more
semanticscholar   +1 more source

Fierce-21: Phase II study of vofatmab (B-701), a selective inhibitor of FGFR3, as salvage therapy in metastatic urothelial carcinoma (mUC).

Journal of Clinical Oncology, 2019
409 Background: Patients (pts) with mUC who have failed platinum-based chemotherapy have a poor prognosis. About 20% of them usually respond to immune checkpoint inhibitors (ICI).
A. Necchi, D. Castellano, B. Mellado, S. Pang, Y. Urun, S. Park, U. Vaishampayan, G. Currie, Esteban Abella-Dominicis, S. Pal   +9 more
semanticscholar   +1 more source

Lestaurtinib (CEP-701) modulates the effects of early life hypoxic seizures on cognitive and emotional behaviors in immature rats.

Epilepsy & Behavior, 2019
Hypoxic encephalopathy of the newborn is a major cause of long-term neurological sequelae. We have previously shown that CEP-701 (lestaurtinib), a drug with an established safety profile in children, attenuates short-term hyperexcitability and ...
Y. Medlej, Houssein Salah, Lara Wadi, Sarah Saad, Bashir Bashir, J. Allam, Zahraa Atoui, Nora Darwish, Nabil Karnib, H. Darwish, F. Kobeissy, K. Wang, E. Hamade, M. Obeid   +13 more
semanticscholar   +1 more source

Anti-BCMA BiTE® AMG 701 Potently Induces Specific T Cell Lysis of Human Multiple Myeloma (MM) Cells and Immunomodulation in the Bone Marrow Microenvironment

Blood, 2018
The first Bispecific T-cell Engager (BiTE®) targeting B-cell maturation antigen (BCMA) on multiple myeloma (MM) cells and CD3 on T cells is currently in clinical development (NCT02514239).
Shih-Feng Cho, Liang Lin, Lijie Xing, Jiye Liu, Tengteng Yu, Kenneth Wen, Phillip A. Hsieh, N. Munshi, K. Anderson, Y. Tai   +9 more
semanticscholar   +1 more source

Histone Deacetylase 701 (HDT701) Induces Flowering in Rice by Modulating Expression of OsIDS1

Molecules and Cells, 2018
Rice is a facultative short-day (SD) plant in which flowering is induced under SD conditions or by other environmental factors and internal genetic programs. Overexpression of Histone Deacetylase 701 (HDT701) accelerates flowering in hybrid rice. In this
Lae-Hyeon Cho, Jinmi Yoon, A. H. Wai, G. An   +3 more
semanticscholar   +1 more source