Results 21 to 30 of about 55,188 (97)

The novel mTOR inhibitor CCI-779 (temsirolimus) induces antiproliferative effects through inhibition of mTOR in Bel-7402 liver cancer cells

Cancer Cell International, 2013
BackgroundLiver cancer is one of the most frequent cancers in the world. Targeted therapy of cancer with specific inhibitors is developing and has shown promising antitumor efficacy.
Shu-yu Li, Yan Liang, Man-lin Wu, Xiaojing Wang, Haixia Fu, Yuhao Chen, Zhigang Wang   +6 more
semanticscholar   +1 more source

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

Science, 2020
The COVID-19 RNA-synthesizing machine Many in the scientific community have mobilized to understand the virus that is causing the global coronavirus disease 2019 (COVID-19) pandemic. Gao et al.
Yan Gao, Liming Yan, Yucen Huang, Fengjiang Liu, Yao Zhao, Lin Cao, Tao Wang, Qianqian Sun, Z. Ming, Lianqi Zhang, Ji Ge, Litao Zheng, Ying Zhang, Haofeng Wang, Yan Zhu, Chen Zhu, T. Hu, T. Hua, Bing Zhang, Xiuna Yang, Jun Li, Haitao Yang, Zhijie Liu, Wenqing Xu, L. Guddat, Quan Wang, Z. Lou, Z. Rao   +27 more
semanticscholar   +1 more source

Clinical and biologic profiles of patients with acute respiratory distress syndrome by prevalence of chronic obstructive pulmonary disease or emphysema; a cohort study

Respiratory Research
Introduction Acute respiratory distress syndrome (ARDS) is characterized by diffuse lung injury. The impact of pre-existing chronic obstructive pulmonary disease (COPD) or emphysema on ARDS pathogenesis is not well characterized.
Sridesh Nath, Hafiz Qurashi, Georgios D. Kitsios, William Bain, Hamam Aneis, Tomeka Suber, Niall Prendergast, Matthew Hensley, Caitlin Schaefer, Yingze Zhang, Jessica Bon, Bryan J. McVerry, John Evankovich, Faraaz Ali Shah   +13 more
doaj   +1 more source

Combined allergic bronchopulmonary mycosis and eosinophilic granulomatosis with polyangiitis: A case report and literature review

Respiratory Medicine Case Reports
A 27-year-old female visited our hospital with a history of asthma, peripheral blood eosinophilia, increased total IgE, Aspergillus fumigatus specific IgE, reversible mild bronchiectasis, sinusitis, bronchial mucus plugs and cultivation of Aspergillus ...
Ning Cui, Jingluan Wang, Yanmei Shao, Jingming Zhao, Zhaozhong Cheng   +4 more
doaj   +1 more source

Atomized inhalation of indocyanine green in thoracoscopic surgery for intralobar pulmonary sequestration: a multicenter study

Respiratory Research
Background Investigate the safety and efficacy of preoperative atomization inhalation of indocyanine green (ICG) solution in precise lesion resection of pediatric thoracoscopic intralobar pulmonary sequestration.
Ye Yin, Guofeng Zhang, Wei LI, Didi Zhuansun, Xiaofeng Xiong, Yanan Li, Yin He, Wenjing Wang, Tianqi Zhu, Jiexiong Feng   +9 more
doaj   +1 more source

Aviptadil: A multifaceted approach to mitigating hypoxemia in acute respiratory distress syndrome

Respiratory Medicine Case Reports
Acute Respiratory Distress Syndrome (ARDS) is a severe and potentially life-threatening lung condition that often leads to Intensive Care Unit (ICU) admissions.
Yatin Mehta, Chitra Mehta, Aravind Chandrasekaran   +2 more
doaj   +1 more source

Ivacaftor ameliorates mucus burden, bacterial load, and inflammation in acute but not chronic P. aeruginosa infection in hG551D rats

Respiratory Research
Background Newly approved highly effective modulation therapies (HEMT) have been life-changing for people with CF. Although these drugs have resulted in significant improvements in lung function and exacerbation rate, bacterial populations in the lung ...
Johnathan D. Keith, Mikayla Murphree-Terry, Gretchen Bollar, Ashley M. Oden, Ian H. Doty, Susan E. Birket   +5 more
doaj   +1 more source

Unilateral intestinal lung disease misdiagnosed as rheumatoid lung disease. A case report of absent pulmonary artery

Respiratory Medicine Case Reports
Unilateral absence of pulmonary artery (UAPA) is a congenital clinical abnormality that is rarely diagnosed in adulthood. Due to its rarity and heterogeneity as it pertains to its clinical presentation, it may be difficult to diagnose, often leading to ...
Bimaje Akpa, Hem Desai
doaj   +1 more source

Successful treatment of a patient with NSCLC carrying uncommon compound L861Q/G719X epidermal growth factor receptor mutations using Afatinib

Respiratory Medicine Case Reports
The availability of targeted therapies for molecular aberrations have substantially improved the outcomes of advanced non-small-cell lung cancer (NSCLC) patients harboring sensitive mutations.
Zihan Zhou, Jie Huang, Ming Ding, Jing Huang, Ting Wu, Qun Wang, Shuhua Han, Yuan Lu   +7 more
doaj   +1 more source

A rare case of MET exon 14 skipping mutation-positive pulmonary sarcomatoid carcinoma with pancreatic metastasis

Respiratory Medicine Case Reports
Lung sarcomatoid carcinoma is a rare tumor. We report a rare case of pancreatic metastasis in a 76-year-old man with lung sarcomatoid carcinoma. Right upper lobectomy was performed, and the patient was diagnosed with pulmonary sarcomatoid carcinoma with ...
Tatsuya Hayashi, Shinji Otani, Riko Kitazawa, Takashi Ueki, Takao Ishimura, Takahito Sugihara, Fumiya Ogura, Yousuke Kiriyama, Yu Mori, Nobuhiko Sakao, Yoshifumi Sano, Hironori Izutani   +11 more
doaj   +1 more source