Results 21 to 30 of about 54,214 (96)

The Rapalogue, CCI-779, Improves Salivary Gland Function following Radiation

PLoS ONE, 2014
The standard of care for head and neck cancer typically includes surgical resection of the tumor followed by targeted head and neck radiation. However depending on tumor location and stage, some cases may not require surgical resection while others may ...
M. Morgan-Bathke, Zoey I. Harris, Deborah G. Arnett, R. Klein, R. Burd, D. Ann, K. Limesand   +6 more
semanticscholar   +1 more source

Deficiency of S100A8/A9 attenuates pulmonary microvascular leakage in septic mice

Respiratory Research, 2023
Background We have reported a positive correlation between S100 calcium-binding protein (S100) A8/S100A9 and sepsis-induced lung damage before.
Jiang Yu, Boying Zhao, Qiangzhong Pi, Guoxiang Zhou, Zhe Cheng, Can Qu, Xiaowen Wang, Lingwen Kong, Suxin Luo, Dingyuan Du, Yongzheng Guo   +10 more
doaj   +1 more source

The novel mTOR inhibitor CCI-779 (temsirolimus) induces antiproliferative effects through inhibition of mTOR in Bel-7402 liver cancer cells

Cancer Cell International, 2013
BackgroundLiver cancer is one of the most frequent cancers in the world. Targeted therapy of cancer with specific inhibitors is developing and has shown promising antitumor efficacy.
Shu-yu Li, Yan Liang, Man-lin Wu, Xiaojing Wang, Haixia Fu, Yuhao Chen, Zhigang Wang   +6 more
semanticscholar   +1 more source

Phosphorylation of Serine 779 in Fibroblast Growth Factor Receptor 1 and 2 by Protein Kinase Cϵ Regulates Ras/Mitogen-activated Protein Kinase Signaling and Neuronal Differentiation*

Journal of Biological Chemistry, 2013
Background: The FGF receptors (FGFRs) regulate pleiotropic (diverse) cellular responses. Results: Serine 779 phosphorylation of FGFR1 and 2 by PKCϵ promotes maximal Ras/MAPK signaling and neuronal differentiation.
A. Lonic, J. Powell, Yang Kong, Daniel Thomas, J. Holien, N. Truong, M. Parker, M. Guthridge   +7 more
semanticscholar   +1 more source

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

Science, 2020
The COVID-19 RNA-synthesizing machine Many in the scientific community have mobilized to understand the virus that is causing the global coronavirus disease 2019 (COVID-19) pandemic. Gao et al.
Yan Gao, Liming Yan, Yucen Huang, Fengjiang Liu, Yao Zhao, Lin Cao, Tao Wang, Qianqian Sun, Z. Ming, Lianqi Zhang, Ji Ge, Litao Zheng, Ying Zhang, Haofeng Wang, Yan Zhu, Chen Zhu, T. Hu, T. Hua, Bing Zhang, Xiuna Yang, Jun Li, Haitao Yang, Zhijie Liu, Wenqing Xu, L. Guddat, Quan Wang, Z. Lou, Z. Rao   +27 more
semanticscholar   +1 more source

Severe community acquired adenovirus pneumonia in an immunocompetent host successfully treated with IV Cidofovir

Respiratory Medicine Case Reports, 2020
Adenovirus is a common cause of acute febrile respiratory infection in children and are generally self-limiting although pneumonia can occur in neonates and adults with compromised immunity. However, severe adenovirus pneumonia in healthy adults has been
Joseph Zhao, Ashton Yap, Eric Wu, Chian Yong Low, Jane Yap   +4 more
doaj   +1 more source

Thymoma Causing Bilateral Upper Extremity Deep Vein Thrombosis

Respiratory Medicine Case Reports, 2020
A 38-year-old African American male presented with progressive pain, swelling, numbness, and warmth of the left upper extremity ten days before admission.
Hoang Bui, Jessica L. Helms, Miguel Sierra-Hoffman, Mark L. Stevens, Rafael Deliz-Aguirre, Miriams T. Castro-Lainez, Rafael J. Deliz   +6 more
doaj   +1 more source

Midregional Proatrial Natriuretic Peptide (MRproANP) is associated with vertebral fractures and low bone density in patients with chronic obstructive pulmonary disease (COPD)

Respiratory Research
Background Patients with COPD are often affected by loss of bone mineral density (BMD) and osteoporotic fractures. Natriuretic peptides (NP) are known as cardiac markers, but have also been linked to fragility-associated fractures in the elderly.
Franziska C. Trudzinski, Rudolf A. Jörres, Peter Alter, Henrik Watz, Claus F. Vogelmeier, Hans-Ulrich Kauczor, Subasini Thangamani, Manuel Debic, Tobias Welte, Jürgen Behr, Kathrin Kahnert, Robert Bals, Christian Herr, Claus Peter Heußel, Jürgen Biederer, Oyunbileg von Stackelberg, Sebastian Fähndrich, Emiel F. M. Wouters, Benjamin Waschki, Klaus F. Rabe, Felix J. F. Herth, Viktoria Palm, COSYCONET study group   +22 more
doaj   +1 more source

Successful recovery from critical COVID-19 pneumonia with extracorporeal membrane oxygenation: A case report

Respiratory Medicine Case Reports, 2020
A public health emergency of current international concern is the outbreak of a severe respiratory illness, that is, coronavirus disease (COVID-19). The disease initially started in Wuhan, China, and it rapidly spread to most regions of the world. Herein,
Yuichi Ikuyama, Yosuke Wada, Kazunari Tateishi, Yoshiaki Kitaguchi, Masanori Yasuo, Atsuhito Ushiki, Kazuhisa Urushihata, Hiroshi Yamamoto, Hiroshi Kamijo, Atsuyoshi Mita, Hiroshi Imamura, Masayuki Hanaoka   +11 more
doaj   +1 more source

Necroptosis plays a role in TL1A-induced airway inflammation and barrier damage in asthma

Respiratory Research
Background Airway epithelial cell (AEC) necroptosis contributes to airway allergic inflammation and asthma exacerbation. Targeting the tumor necrosis factor-like ligand 1 A (TL1A)/death receptor 3 (DR3) axis has a therapeutic effect on asthmatic airway ...
Xiaofei Liu, Jintao Zhang, Dong Zhang, Yun Pan, Rong Zeng, Changjuan Xu, Shuochuan Shi, Jiawei Xu, Qian Qi, Xueli Dong, Junfei Wang, Tian Liu, Liang Dong   +12 more
doaj   +1 more source