Results 31 to 40 of about 53,372 (96)

Role of ethambutol and rifampicin in the treatment of Mycobacterium avium complex pulmonary disease

BMC Pulmonary Medicine, 2019
Background A three-drug regimen (macrolide, ethambutol, and rifampicin) is recommended for the treatment of Mycobacterium avium complex pulmonary disease (MAC-PD).
Hyung-Jun Kim, Jong Sik Lee, Nakwon Kwak, Jaeyoung Cho, Chang-Hoon Lee, Sung Koo Han, Jae-Joon Yim   +6 more
doaj   +1 more source

Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer.

Journal of Clinical Oncology, 2005
PURPOSE In this study, two doses of temsirolimus (CCI-779), a novel inhibitor of the mammalian target of rapamycin, were evaluated for efficacy, safety, and pharmacokinetics in patients with locally advanced or metastatic breast cancer who had been ...
S. Chan, M. Scheulen, S. Johnston, K. Mross, F. Cardoso, C. Dittrich, W. Eiermann, D. Hess, R. Morant, V. Semiglazov, M. Borner, M. Salzberg, V. Ostapenko, H. Illiger, D. Behringer, N. Bardy-Bouxin, J. Boni, S. Kong, M. Cincotta, L. Moore   +19 more
semanticscholar   +1 more source

Autophagy and pulmonary disease

Therapeutic Advances in Respiratory Disease, 2019
Autophagy is a process of cell self-renewal that is dependent on the degradation of the cytoplasmic proteins or organelles of lysosomes. Many diseases, such as metabolic diseases, cancer, neurodegenerative diseases, and lung diseases, have been confirmed
Shi-xia Liao, Peng-peng Sun, Yan-hui Gu, Xi-min Rao, Lan-ying Zhang, Yao Ou-Yang   +5 more
doaj   +1 more source

Sonic hedgehog signalling as a potential endobronchial biomarker in COPD

Respiratory Research, 2020
Background The hedgehog (HH) pathway has been associated with chronic obstructive pulmonary disease (COPD) in genome-wide association studies and recent studies suggest that HH signalling could be altered in COPD.
Julien Ancel, Randa Belgacemi, Jeanne-Marie Perotin, Zania Diabasana, Sandra Dury, Maxime Dewolf, Arnaud Bonnomet, Nathalie Lalun, Philippe Birembaut, Myriam Polette, Gaëtan Deslée, Valérian Dormoy   +11 more
doaj   +1 more source

Derrame pleural secundário à hiperestimulação ovariana Pleural effusion following ovarian hyperstimulation

Jornal Brasileiro de Pneumologia, 2012
A síndrome de hiperestimulação ovariana (SHEO) é uma complicação iatrogênica que ocorre na fase lútea de um ciclo hormonal induzido. Na maioria dos casos, os sintomas são autolimitados e regridem espontaneamente. Entretanto, casos graves comumente cursam
Jader Joel Machado Junqueira, Ricardo Helbert Bammann, Ricardo Mingarini Terra, Ana Cristina P. Castro, Augusto Ishy, Angelo Fernandez   +5 more
doaj   +1 more source

Multiple endo bronchial lipoma: a rare case report

BMC Pulmonary Medicine, 2020
Background Endobronchial lipoma is an extremely rare benign tumor, which is generally located in the first three subdivisions of the tracheobronchial tree. According to the existing literature, all endobronchial lipomas are single (one per patient). Here,
Shunjin Zhao, Yuexiang Shui, Zhong Dai
doaj   +1 more source

Perifosine and CCI 779 Co-Operate to Induce Cell Death and Decrease Proliferation in PTEN-Intact and PTEN-Deficient PDGF-Driven Murine Glioblastoma

PLoS ONE, 2011
Background Platelet derived growth factor receptor (PDGFR) activity is deregulated in human GBM due to amplification and rearrangement of the PDGFR-alpha gene locus or overexpression of the PDGF ligand, resulting in the activation of downstream kinases ...
K. Pitter, C. Galbán, S. Galban, Omid Saeed-Tehrani, Fei Li, Nikki Charles, M. Bradbury, O. Becher, T. Chenevert, A. Rehemtulla, B. Ross, E. Holland, D. Hambardzumyan   +12 more
semanticscholar   +1 more source

Club Cell Secretory Protein (CCSP) is Reduced in Hospitalized Chronic Obstructive Pulmonary Disease (COPD) Exacerbations

International Journal of COPD, 2020
Arianne K Baldomero,1,2 Ken M Kunisaki,1,2 John Connett,3 Aprile Pilon,4 Chris H Wendt1,2 1Pulmonary, Allergy, Critical Care, and Sleep Medicine, Minneapolis VA Health Care System, Minneapolis, MN, USA; 2Pulmonary, Allergy, Critical Care, and Sleep ...
Baldomero AK, Kunisaki KM, Connett J, Pilon A, Wendt CH   +4 more
doaj  

Phase I trial of lenalidomide and CCI-779 in patients with relapsed multiple myeloma: evidence for lenalidomide-CCI-779 interaction via P-glycoprotein.

Journal of Clinical Oncology, 2011
PURPOSE Multiple myeloma (MM) is an incurable plasma-cell neoplasm for which most treatments involve a therapeutic agent combined with dexamethasone. The preclinical combination of lenalidomide with the mTOR inhibitor CCI-779 has displayed synergy in ...
C. Hofmeister, Xiaoxia Yang, F. Pichiorri, Ping Chen, Darlene M. Rozewski, A. Johnson, Seungsoo Lee, Zhongfa Liu, C. Garr, E. Hade, Jia Ji, L. Schaaf, D. Benson, E. Kraut, W. Hicks, K. Chan, Ching S. Chen, S. Farag, M. Grever, J. Byrd, M. Phelps   +20 more
semanticscholar   +1 more source

Endobronchial metastasis of ovarian cancer rescued by tumor ablation and a self-expanding hybrid stent: A case report and review of the literature

Respiratory Medicine Case Reports, 2020
Tracheal stenosis caused by malignancy is a life-threatening complication. Herein, we performed tumor ablation and airway stenting using a hybrid stent on a patient with upper tracheal stenosis caused by endobronchial metastasis of ovarian cancer.
Daisuke Himeji, Gen-ichi Tanaka, Chikara Fukuyama, Ritsuya Shiiba, Takeshi Murakami, Moriguchi Sayaka, Kousuke Marutsuka   +6 more
doaj