Results 31 to 40 of about 54,214 (96)

The integrin receptor beta7 subunit mediates airway remodeling and hyperresponsiveness in allergen exposed mice

Respiratory Research
Background Fibroblast differentiation to a myofibroblast phenotype is a feature of airway remodeling in asthma. Lung fibroblasts express the integrin receptor α4β7 and fibronectin induces myofibroblast differentiation via this receptor.
Miri Assayag, Tahrir Obedeyah, Avraham Abutbul, Neville Berkman   +3 more
doaj   +1 more source

The management pattern and outcomes of chronic thromboembolic pulmonary hypertension: rationale and design for a Chinese real-world study

BMC Pulmonary Medicine
Background Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive pulmonary vascular disorder with substantial morbidity and mortality, also a disease underdiagnosed and undertreated. It is potentially curable by pulmonary endarterectomy (
Shuai Zhang, Yishan Li, Yuanhua Yang, Sugang Gong, Zhenwen Yang, Cheng Hong, Xiaopei Cui, Jun Wan, Yingqun Ji, Hong Chen, Ling Zhu, Chenghong Li, Zhaozhong Cheng, Yunhui Zhang, Qiguang Wang, Qin Luo, Lu Guo, Guofeng Ma, Baoshi Han, Zhihong Liu, Changming Xiong, Lan Wang, Qiushang Ji, Fajiu Li, Shengfeng Wang, Zhu Zhang, Yunxia Zhang, Dingyi Wang, Qian Gao, Qiang Huang, Wanmu Xie, Zhenguo Zhai, Chen Wang   +32 more
doaj   +1 more source

Association between lactate dehydrogenase and ventilator-associated pneumonia risk: an analysis of the MIMIC database 2001–2019

BMC Pulmonary Medicine
Background Serum lactate dehydrogenase (LDH) is a nonspecific inflammatory biomarker and has been reported to be associated with pneumonia prognosis. This study aimed to evaluate the relationship between LDH levels and ventilator-associated pneumonia ...
Xiangfeng Qian, Yi Sheng, Yinsheng Jiang, Yongan Xu   +3 more
doaj   +1 more source

Perifosine and CCI 779 Co-Operate to Induce Cell Death and Decrease Proliferation in PTEN-Intact and PTEN-Deficient PDGF-Driven Murine Glioblastoma

PLoS ONE, 2011
Background Platelet derived growth factor receptor (PDGFR) activity is deregulated in human GBM due to amplification and rearrangement of the PDGFR-alpha gene locus or overexpression of the PDGF ligand, resulting in the activation of downstream kinases ...
K. Pitter, C. Galbán, S. Galban, Omid Saeed-Tehrani, Fei Li, Nikki Charles, M. Bradbury, O. Becher, T. Chenevert, A. Rehemtulla, B. Ross, E. Holland, D. Hambardzumyan   +12 more
semanticscholar   +1 more source

Serum S1P level in interstitial lung disease (ILD) is a potential biomarker reflecting the severity of pulmonary function

BMC Pulmonary Medicine
Background sphingosine-1-phosphate (S1P), a naturally occurring sphingolipid, has been involved in pulmonary interstitial remodeling signaling. However, no study has examined its clinical merits for interstitial lung disease (ILD).
Fangping Ding, Zhenyang Wang, Jing Wang, Yingmin Ma, Jiawei Jin   +4 more
doaj   +1 more source

Impulse oscillometry for detection of small airway dysfunction in subjects with chronic respiratory symptoms and preserved pulmonary function

Respiratory Research, 2021
Background Subjects with chronic respiratory symptoms and preserved pulmonary function (PPF) may have small airway dysfunction (SAD). As the most common means to detect SAD, spirometry needs good cooperation and its reliability is controversial.
Liang-Yuan Li, Tian-Sheng Yan, Jing Yang, Yu-Qi Li, Lin-Xi Fu, Lan Lan, Bin-Miao Liang, Mao-Yun Wang, Feng-Ming Luo   +8 more
doaj   +1 more source

Outcomes of biological therapy in patients with severe asthma with chronic rhinosinusitis in Saudi Arabia: patients with nasal polyps versus those without nasal polyps

BMC Pulmonary Medicine
Background This study’s purposes were to evaluate the impact of biological therapies on outcomes in patients with severe asthma (SA) and chronic rhinosinusitis (CRS) and to compare these effects among those with NP (CRSwNP) versus those without NP ...
Usama E. Abuelhassan, Medhat Elnamaky, Abdulaziz Alfifi, Sultan K. Kadasah, Mohammed A. Alshehri, Haneen A. Alasiri, Salihah Y. Al-Mani, Ali S. Kadasah, Abdullah Musleh, Fawwaz A. Alshafa, Muhammad S. S. Qureshi, Abdulmohsen Y. Assiri, Abdulrahman I. Falqi, Bader I. Asiri, Haider M. O. Ahmed, Saleem Alshehri, Fasih U. Rahman, Muhammad Amir Qureshi, Omar Abdelwahab, Sherif Mohamed, Ahmed R. I. Ali, Saad M. A. Alqahtani, Abdelrahman M. Abdalla   +22 more
doaj   +1 more source

Cluster analysis in 975 patients with current cough identifies a phenotype with several cough triggers, many background disorders, and low quality of life

Respiratory Research, 2020
Background Recognition of disorder phenotypes may help to estimate prognosis and to guide the clinical management. Current cough management guidelines classify patients according to the duration of the cough episode.
Heikki O. Koskela, Tuomas A. Selander, Anne M. Lätti   +2 more
doaj   +1 more source

Successful treatment with alectinib after crizotinib-induced hepatitis in ALK-rearranged advanced lung cancer patient: a case report

BMC Pulmonary Medicine, 2021
Background Besides the clinical benefit of crizotinib in ALK-rearranged metastatic non-small cell lung cancer (NSCLC), concerns about its hepatotoxicity have arisen.
Flávia Amaral Duarte, Leonardo Brand Rodrigues, Flávia Rocha Paes, Paulo Henrique Costa Diniz, Helena Flávia Cuba de Almada Lima   +4 more
doaj   +1 more source

Performance of risk scores in predicting mortality at 3, 6, and 12 months in patients diagnosed with community-acquired pneumonia

BMC Pulmonary Medicine
Background Risk scores (RS) evaluate the likelihood of short-term mortality in patients diagnosed with community-acquired pneumonia (CAP). However, there is a scarcity of evidence to determine the risk of long-term mortality. This article aims to compare
Eduardo Tuta-Quintero, Alirio R. Bastidas, Gabriela Guerrón-Gómez, Isabella Perna-Reyes, Daniela Torres, Laura Garcia, Javier Villanueva, Camilo Acuña, Eathan Mikler, Juan Arcila, Nicolas Chavez, Allison Riviera, Valentina Maldonado, María Galindo, María Fernández, Carolina Schloss, Luis Felipe Reyes   +16 more
doaj   +1 more source