Results 21 to 30 of about 64,665 (70)

Sphingosine Kinase 1 Aggravates Liver Fibrosis by Mediating Macrophage Recruitment and PolarizationSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Sphingosine kinase 1 (SphK1) has distinct roles in the activation of Kupffer cells and hepatic stellate cells in liver fibrosis. Here, we aim to investigate the roles of SphK1 on hepatic macrophage recruitment and polarization in ...
Xin Ding, Xiang Zhang, Jiafan Cao, Shiyun Chen, Yinghua Chen, Kai Yuan, Bo Chen, Guizhi Yang, Shengwen Li, Jundong Yang, Guixiang Wang, Frank Tacke, Tian Lan   +12 more
doaj   +1 more source

Modernizing metabolic dysfunction-associated steatotic liver disease diagnostics: the progressive shift from liver biopsy to noninvasive techniques

Therapeutic Advances in Gastroenterology
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing public health concern worldwide. Liver biopsy is the gold standard for diagnosing and staging MASLD, but it is invasive and carries associated risks. In recent years, there has
David Hudson, Tamoor Afzaal, Hasan Bualbanat, Raaed AlRamdan, Nisha Howarth, Pavithra Parthasarathy, Alia AlDarwish, Emily Stephenson, Yousef Almahanna, Maytham Hussain, Luis Antonio Diaz, Juan Pablo Arab   +11 more
doaj   +1 more source

Intestinal Stearoyl-CoA Desaturase-1 Regulates Energy Balance via Alterations in Bile Acid HomeostasisSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Stearoyl-CoA desaturase-1 (SCD1) converts saturated fatty acids into monounsaturated fatty acids and plays an important regulatory role in lipid metabolism.
Natalie Burchat, Jeanine Vidola, Sarah Pfreundschuh, Priyanka Sharma, Daniel Rizzolo, Grace L. Guo, Harini Sampath   +6 more
doaj   +1 more source

Dysrupted microbial tryptophan metabolism associates with SARS-CoV-2 acute inflammatory responses and long COVID

Gut Microbes
Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and risk of long COVID has been associated with the depletion or over-abundance of specific taxa within the gut microbiome.
Lu Yao, Hannah Devotta, Junhui Li, Nonhlanhla Lunjani, Corinna Sadlier, Aonghus Lavelle, Werner C. Albrich, Jens Walter, Paul W. O’Toole, Liam O’Mahony   +9 more
doaj   +1 more source

Intrahepatic Exhausted Antiviral Immunity in an Immunocompetent Mouse Model of Chronic Hepatitis BSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Targeting exhausted immune systems would be a promising therapeutic strategy to achieve a functional cure for HBV infection in patients with chronic hepatitis B (CHB). However, animal models recapitulating the immunokinetics of CHB
Satoshi Shigeno, Takahiro Kodama, Kazuhiro Murai, Daisuke Motooka, Akihisa Fukushima, Akira Nishio, Hayato Hikita, Tomohide Tatsumi, Toru Okamoto, Tatsuya Kanto, Tetsuo Takehara   +10 more
doaj   +1 more source

Tumor-Derived Exosomal Circular RNA Pinin Induces FGF13 Expression to Promote Colorectal Cancer Progression through miR-1225-5p

Gut and Liver
Background/Aims: Colorectal cancer (CRC) is a common malignant tumor, and circular RNAs (circRNAs) are abnormally expressed in CRC. However, the function and underlying mechanism of circRNA pinin (circ-PNN; hsa_circ_0101802) in CRC remain unclear ...
Xianghui Liao, Tuhua Li, Li Yang, Haiwen Li, Weiru Li, Yuting Liu, Zhong Xie   +6 more
doaj   +1 more source

Combi-Elastography versus Transient Elastography for Assessing the Histological Severity of Metabolic Dysfunction-Associated Steatotic Liver Disease

Gut and Liver
Background/Aims: Combi-elastography is a B-mode ultrasound-based method in which two elastography modalities are utilized simultaneously to assess metabolic dysfunction-associated steatotic liver disease (MASLD).
Yun Kyu Lee, Dong Hyeon Lee, Sae Kyung Joo, Heejoon Jang, Young Ho So, Siwon Jang, Dong Ho Lee, Jeong Hwan Park, Mee Soo Chang, Won Kim, Innovative Target Exploration of NAFLD (ITEN) Consortium   +10 more
doaj   +1 more source

Cognitive Impairment and Insomnia in Celiac Disease: A Systematic Review and Meta-Analysis

Gut and Liver
Emerging evidence suggests a broader spectrum of celiac disease (CeD) system involvement, including neurological manifestations. We aimed to conduct a systematic review and meta-analysis of the available evidence from studies assessing the association of
Renato Beas, Ambar Godoy, Dalton A. Norwood, Ysaith Orellana Ascencio, Diego Izquierdo-Veraza, Eleazar E. Montalvan-Sanchez, Mirian Ramirez, Satya Kurada   +7 more
doaj   +1 more source

Genetically-modified, redirected T cells target hepatitis B surface antigen-positive hepatocytes and hepatocellular carcinoma lesions in a clinical setting [PDF]

Clinical and Molecular Hepatology
Background/Aims Hepatitis B virus (HBV)-DNA integration in HBV-related hepatocellular carcinoma (HBV-HCC) can be targeted by HBV-specific T cells. SCG101 is an autologous, HBV-specific T-cell product expressing a T-cell receptor (TCR) after lentiviral ...
Xueshuai Wan, Karin Wisskirchen, Tao Jin, Lu Yang, Xiaorui Wang, Xiang’an Wu, Fang Liu, Yu Wu, Christy Ma, Yong Pang, Qi Li, Ke Zhang, Ulrike Protzer, Shunda Du   +13 more
doaj   +1 more source

Metal Stents for the Management of Massive Hemobilia in Patients with Hilum-Involving Cholangiocarcinoma Receiving Multi-Regimen Chemotherapy

Gut and Liver
Recent clinical outcomes of multi-regimen chemotherapy in patients with cholangiocarcinoma (CCC) have shown benefits in terms of overall survival.
Seung Yeon Lee, Min Je Sung, Suk Pyo Shin, Hong Jae Chon, Beodeul Kang, Kwang Hyun Ko, Mamoru Takenaka, Chang-Il Kwon   +7 more
doaj   +1 more source