Epilepsia, EarlyView.Abstract Objective This study was undertaken to investigate the molecular consequences of pathogenic variants in the SMC1A gene—particularly those associated with developmental and epileptic encephalopathy (DEE85)—and to evaluate the therapeutic potential of ataluren in restoring SMC1A function and mitigating disease‐related transcriptomic and genomic ...
Maddalena Di Nardo +7 more
wiley +1 more source
Epilepsy surgery: From bench to the clinics
Epilepsia Open, EarlyView.Abstract Objective Recent advances in epilepsy surgery in patients with intractable epilepsy make it possible to study the mechanism of epilepsy in human brains. However, the true extent and propagation of each epileptogenic area from the epileptogenic focus in each patient is still difficult to perform “epilepsy cure” by surgery.
Tatsuya Tanaka
wiley +1 more source
The design considerations of steel braced frame for seismic retrofit through increasing the lateral strength of existing RC buildings [PDF]
, 2013 Choong Weon Ahn +4 more
openalex +1 more source
Quantifying Model Selection Uncertainty in Structural Analysis: Methodology and Application
Earthquake Engineering &Structural Dynamics, EarlyView.ABSTRACT With increasing focus on complex engineering systems under rare events, computational models are critical for predictions due to the scarcity or absence of data. However, selecting an appropriate model can be challenging. Using a single model without available test calibration could result in significant bias in performance predictions. A case
Ya‐Heng Yang, Tracy C. Becker
wiley +1 more source
Finite Element Modelling of Rocking and Hybrid Precast Walls under Seismic Loading
Earthquake Engineering &Structural Dynamics, EarlyView.ABSTRACT In recent years, self‐centring systems have received considerable research interest in the seismic design of precast concrete structures for their ability to limit damage and satisfy resilience requirements. Rocking and hybrid structural walls, characterised by the formation of a single gap at the wall–foundation interface, mitigate damage by ...
Andrea Belleri +3 more
wiley +1 more source
Investigation of finite element simulation-based bond-slip effect for seismically vulnerable school reinforced concrete building frame. [PDF]
Sci RepKang H, Lee K, Shin S, Woo J, Shin J.
europepmc +1 more source
Assessment of double story single bar RC frame through FEM modelling
Ammar T. Al-Sayegh
openalex +1 more source
Navigating the Dual Pandemics: Challenges to Faculty Diversity and Student Success
New Directions for Community Colleges, EarlyView.
Lorenzo Baber +3 more
wiley +1 more source
Earthquake Engineering &Structural Dynamics, EarlyView.ABSTRACT Nonstructural components (NSCs) installed in large‐span reticular structures were frequently severely damaged during earthquakes, even when the primary structure remained intact. Existing seismic design specifications for NSCs were predominantly developed for upright structures such as multi‐storey buildings and offer no guidance for reticular
Xudong Zhi +6 more
wiley +1 more source
Advanced single-strut modelling of lightweight in-filled RC frames: validation and seismic performance assessment. [PDF]
Sci RepEl-Fotuh GA, Attia WA, El-Feky MS.
europepmc +1 more source