Results 31 to 40 of about 59,155 (100)

Combined femoral and tibial component total knee arthroplasty device rotation measurement is reliable and predicts clinical outcome

Journal of Orthopaedics and Traumatology, 2023
Background The optimal total knee arthroplasty (TKA) rotational alignment and how best to obtain and measure it are debatable. The aim was to analyse the reliability of the Berger femoral, three different tibial and four different combined two ...
José A. Hernández-Hermoso, Lexa Nescolarde, Federico Yañez-Siller, Juan Calle-García, Damian Garcia-Perdomo, Ricard Pérez-Andres   +5 more
doaj   +1 more source

Brief Report: Pharmacodynamics, Safety, and Clinical Efficacy of AMG 811, a Human Anti–Interferon‐γ Antibody, in Patients With Discoid Lupus Erythematosus

Arthritis & Rheumatology, 2017
Interferon‐γ (IFNγ) is implicated in the pathogenesis of discoid lupus erythematosus (DLE). This study sought to evaluate a single dose of AMG 811, an anti‐IFNγ antibody, in patients with DLE.
V. Werth, D. Fiorentino, B. Sullivan, M. Boedigheimer, Kit Chiu, Christine Wang, G. E. Arnold, M. Damore, J. Bigler, A. Welcher, C. Russell, David A. Martin, J. Chung   +12 more
semanticscholar   +1 more source

A Novel Internal Fixation Design for the Treatment of AO/OTA‐31A3.3 Intertrochanteric Fractures: Finite Element Analysis

Orthopaedic Surgery
Objective AO/OTA 31‐A3.3 intertrochanteric fracture is the most unstable type of intertrochanteric fracture, with a high rate of postoperative complications and implant failure.
Xiaofeng Chen, Miaotian Tang, Xiaomeng Zhang, Yichong Zhang, Yilin Wang, Chen Xiong, Yun Ji, Yanhua Wang, Dianying Zhang   +8 more
doaj   +1 more source

Long-term clinical and radiographic outcomes of arthroscopic acromioclavicular stabilization for acute acromioclavicular joint dislocation [PDF]

Clinics in Shoulder and Elbow
Background Standard open acromioclavicular (AC) stabilization is associated with increased postoperative complications including deltoid injury, infection, tunnel complications, loss of reduction, and wound/cosmetic concerns.
Eduard Van Eecke, Bernard Struelens, Stijn Muermans   +2 more
doaj   +1 more source

Degree of articular injury as measured by CT cross sectional area is associated with physical function following the treatment of bicondylar tibial plateau fractures

Journal of Orthopaedic Surgery, 2023
Background Bicondylar tibial plateau fractures are complex injuries that commonly require surgical repair. Long-term clinical outcome has been associated with discrepancies in leg alignment, instability and condylar width abnormalities.
Arvind von Keudell, Kyla D Huebner, Jacob Mandell, Matthew O’Brien, Mitchel B Harris, John G Esposito, Tyler Caton, Michael J Weaver   +7 more
doaj   +1 more source

Biomechanical Properties of Novel Porous Scaffold Core and Hollow Lateral Hole Pedicle Screws: A Comparative Study in Bama Pigs

Orthopaedic Surgery
Objective Screw loosening is a common complication of internal fixation of pedicle screw. Therefore, the development of a pedicle screw with low loosening rate and high biosafety is of great clinical significance.
Yong Hu, Xijiong Chen, Zhentao Chu, Linwei Luo, Zhiwei Gan, Jianbin Zhong, Zhenshan Yuan, Bingke Zhu, Weixin Dong   +8 more
doaj   +1 more source

Effect of different lumbar–iliac fixation and sacral slope for Tile C1.3 pelvic fractures: a biomechanical study

Journal of Orthopaedics and Traumatology
Background Lumbar–iliac fixation (LIF) is a common treatment for Tile C1.3 pelvic fractures, but different techniques, including L4–L5/L5 unilateral LIF (L4–L5/L5 ULIF), bilateral LIF (BLIF), and L4–L5/L5 triangular osteosynthesis (L4–L5/L5 TOS), still ...
Shicai Fan, Hongjie Luo, Sheqiang Chen, Haibo Xiang, Qiguang Mai, Zhenhua Zhu, Yuhui Chen, Zhiyong Hou, Wei Chen, Qingan Zhu, Yingze Zhang   +10 more
doaj   +1 more source

Safety, pharmacokinetics and pharmacodynamics of AMG 811, an anti-interferon-γ monoclonal antibody, in SLE subjects without or with lupus nephritis

Lupus Science and Medicine, 2017
Objective To evaluate safety, pharmacokinetics and pharmacodynamics of anti-interferon (IFN)-γ monoclonal antibody AMG 811 in subjects with SLE without or with lupus nephritis (LN).
Michael J Boedigheimer, David A. Martin, Zahir Amoura, J. Sánchez-Guerrero, J. Romero-Díaz, A. Kivitz, C. Aranow, Tak Mao Chan, Yip Boon Chong, Kit Chiu, Christine Wang, W. Sohn, G. E. Arnold, M. Damore, A. Welcher, Barbara A. Sullivan, Brian L. Kotzin, James B. Chung   +17 more
semanticscholar   +1 more source

PAN-811 prevents chemotherapy-induced cognitive impairment and preserves neurogenesis in the hippocampus of adult rats

PLoS ONE, 2018
Chemotherapy-induced cognitive impairment (CICI) occurs in a substantial proportion of treated cancer patients, with no drug currently available for its therapy.
Zhi-Gang Jiang, G. Winocur, J. Wojtowicz, O. Shevtsova, S. Fuller, H. Ghanbari   +5 more
semanticscholar   +1 more source

The effect of the IL-6 monoclonal blocker on the course of aseptic femoral head necrosis in the experiment (pilot study)

Гений oртопедии
Background There is currently no pathogenetically based treatment for aseptic necrosis of the femoral head. One of the most promising areas of possible targeted therapy is the use of genetically engineered drugs, including monoclonal blockers of ...
Nikita A. Shabaldin, Anna V. Sinitskaya, Lyudmila N. Igisheva, Lev A. Bogdanov, Andrey V. Shabaldin   +4 more
doaj   +1 more source