Results 211 to 220 of about 86,065 (262)

Microbial product translocation and mortality in adults hospitalised with HIV-associated tuberculosis: a prospective observational cohort study

Schutz C, Queiroz A, Mota T, Ward A, Barr D, Janssen S, Shey M, Wilkinson R, Wilkinson K, Burton R, Lelouvier B, Andrade B, Meintjes G.   +12 more
europepmc   +1 more source

Variability of Human rDNA [PDF]

Cells, 2021
In human cells, ribosomal DNA (rDNA) is arranged in ten clusters of multiple tandem repeats. Each repeat is usually described as consisting of two parts: the 13 kb long ribosomal part, containing three genes coding for 18S, 5.8S and 28S RNAs of the ribosomal particles, and the 30 kb long intergenic spacer (IGS).
Pavla Bažantová, Evgeny Smirnov, Dusan Cmarko   +2 more
exaly   +4 more sources

Human rDNA and Cancer [PDF]

Cells, 2021
In human cells, each rDNA unit consists of the ~13 kb long ribosomal part and ~30 kb long intergenic spacer (IGS). The ribosomal part, transcribed by RNA polymerase I (pol I), includes genes coding for 18S, 5.8S, and 28S RNAs of the ribosomal particles, as well as their four transcribed spacers.
Evgeny Smirnov, Dusan Cmarko, Nikola Chmúrčiaková   +2 more
exaly   +4 more sources

Evolution of rDNA in Nicotiana Allopolyploids: A Potential Link between rDNA Homogenization and Epigenetics [PDF]

Annals of Botany, 2008
The evolution and biology of rDNA have interested biologists for many years, in part, because of two intriguing processes: (1) nucleolar dominance and (2) sequence homogenization. We review patterns of evolution in rDNA in the angiosperm genus Nicotiana to determine consequences of allopolyploidy on these processes.Allopolyploid species of Nicotiana ...
Sandra Knapp, Andrew R Leitch, James J Clarkson   +2 more
exaly   +3 more sources

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Expression of rDNA insertions during rDNA magnification in D. melanogaster

Molecular and General Genetics MGG, 1983
In D. melanogaster, many ribosomal genes contain an intervening sequence that interrupts the 28S rRNA gene. In wild-type flies, type I and type II insertions are rarely transcribed and the transcripts of the interrupted genetic units do not contribute significantly to the production of mature ribosomal RNA. We demonstrate that during rDNA magnification,
T, Labella, L, Vicari, A, Manzi, F, Graziani   +3 more
openaire   +2 more sources

Evidence for an excess of rDNA in the testis ofDrosophila melanogaster during rDNA magnification

Molecular and General Genetics MGG, 1977
Hybridization of rRNA and DNA extracted from different tissues of different genotypes have been performed. The results show that: 1) in DNA extracted from the testis of premagnified males there exists an excess of rDNA, which is consistent with the model proposed by Ritossa (1972) and by us (1973) to explain the phenomenon of magnification.
D, Locker, M, Marrakechi
openaire   +2 more sources

Amplification of rDNA and type I sequences in Drosophila males deficient in rDNA

Cell, 1983
rDNA magnification is a heritable change in rDNA content that occurs in D. melanogaster males when chromosomes deficient in rDNA are placed together for several generations. We have examined the restriction endonuclease cleavage pattern of the rDNA from an X chromosome undergoing magnification, and find no evidence for the selective amplification of ...
D V, de Cicco, D M, Glover
openaire   +2 more sources

Regulation of rDNA stability by sumoylation

DNA Repair, 2009
Repair of DNA lesions by homologous recombination relies on the copying of genetic information from an intact homologous sequence. However, many eukaryotic genomes contain repetitive sequences such as the ribosomal gene locus (rDNA), which poses a risk for illegitimate recombination.
Eckert-Boulet, Nadine, Lisby, Michael
openaire   +3 more sources

Chromosomal localization of rDNA in the gorilla

Cytogenetic and Genome Research, 1998
Twenty-five specimens of lowland gorilla, including 24 specimens of the western lowland gorilla <i>(Gorilla gorilla gorilla) </i>and 1 specimen of the eastern lowland gorilla<i> (G. gorilla graueri), </i>were investigated by fluorescence in situ hybridization with a human-derived 18S + 28S rDNA probe.
W, Schempp, S, Zeitler, W, Rietschel
openaire   +2 more sources

rDNA transcription and cardiac hypertrophy

Trends in Cardiovascular Medicine, 1993
A common result of the various stimuli that alter the growth rates of cells is a parallel alteration of the rate of ribosome biogenesis. In many cell types, this mandates an altered rate of ribosomal RNA synthesis. Preliminary studies indicate that rDNA transcription may in fact be regulated at more than one level or step.
W, Xie, L I, Rothblum
openaire   +2 more sources