Results 111 to 120 of about 20,697 (216)

Beyond Traditional Covariates: An Interpretable Machine Learning Workflow for Improved Hybrid Pharmacometric Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Model‐informed precision dosing is often constrained by the limited generalizability of traditional population pharmacokinetic models, especially in critically ill patients. A hybrid machine learning‐population pharmacokinetic framework is proposed to improve a priori pharmacokinetic predictions by integrating real‐world clinical data.
Freek J. A. Relouw, Jort J. M. T. Lokers, Tim Preijers, Sebastiaan D. T. Sassen, Natal A. W. van Riel, Birgit C. P. Koch   +5 more
wiley   +1 more source

Multivalent Bi‐Specific Nanoerythrosomes: A Two‐Birds‐One‐Stone Approach to Combine Homologous and Active Targeting for Effective Thrombolysis

Small, Volume 22, Issue 47, 21 August 2026.
A multivalent bi‐specific nanoerythrosome (mBiNE@tPA) is developed as a “two‐birds‐one‐stone” platform that simultaneously exploits two principal thrombus components. By integrating erythrocyte membrane‐mediated homologous targeting with cRGD‐based active targeting to activated platelets, mBiNE@tPA achieves enhanced thrombus accumulation, triggered ...
Yu Huang, Yilin Yang, Nicole Henry, Boram Gu, Jiahua Wang, Yuanyuan Guo, Colin Longstaff, Simon A. Thom, Yuehua Li, Xiao Yun Xu, Rongjun Chen   +10 more
wiley   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, Volume 81, Issue 8, Page 2675-2712, August 2026.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

Enriched Metabolic Phenotyping Refines Phenotypic Resolution of Type 2 Diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6674-6686, August 2026.
ABSTRACT Aims Data‐driven clustering studies of type 2 diabetes (T2D) based on limited routine clinical variables have reproducibly described major metabolic subgroups, including severe insulin‐deficient diabetes (SIDD), severe insulin‐resistant diabetes (SIRD), mild obesity‐related diabetes and mild age‐related diabetes.
Min Wang, Yang Ou, Heng Su, Bing Zhang, Ben Niu, Anwar Ahmed, Guoqiang Xing   +6 more
wiley   +1 more source

Primary cardiac T‐cell rich large B‐cell lymphoma causing aortic stenosis with metastasis in a Warmblood

Equine Veterinary Education, Volume 38, Issue 8, Page e488-e495, August 2026.
Summary An 18‐year‐old Warmblood mare was presented to the Royal Veterinary College Equine Referral Hospital for investigation of progressive periocular and facial swelling, weight loss and tachycardia. Physical examination additionally identified bilateral pansystolic (grade 5/6 basilar left‐sided, 2/6 right‐sided), cardiac murmurs, submandibular ...
S. E. Talbot, F. Z. X. Lean, H. M. Martineau, B. Dunkel, J. Reed   +4 more
wiley   +1 more source

Investigation of the clinical significance of RDW in sepsis

Abstract Objective Our study focused on the clinical relevance of red blood cell distribution width (RDW) in sepsis. Methods This retrospective analysis involved 57 sepsis patients from the University-Town Hospital of Chongqing Medical University (observation group) between February 2021 and November 2024, and 46 healthy controls who were ...
Wei Cai, Jia Liu, Yaqian Jin, Pan Xu
openaire   +1 more source

Analytical and Clinical Performance of the Atellica HEMA 580 Haematology Analyzer: A Comparison With the ADVIA 2120i

International Journal of Laboratory Hematology, Volume 48, Issue 4, Page 784-794, August 2026.
ABSTRACT Introduction The Atellica HEMA 580 is a novel haematology analyser providing eight‐part leukocyte differential and optical platelet (PLT) counting. We compared its analytical and clinical performance with that of the ADVIA 2120i. Methods A total of 796 residual whole blood specimens were analysed.
Hyeongyu Lee, Jooyoung Cho, Gilsung Yoo, Juwon Kim   +3 more
wiley   +1 more source

Two‐Year Pathogen Dynamics, Coinfection Features, and Core Risk Factors Associated With Severe Pediatric Acute Respiratory Tract Infections in Hangzhou, China

Influenza and Other Respiratory Viruses, Volume 20, Issue 8, August 2026.
ABSTRACT Background Acute respiratory tract infections (ARTI) remain a major public health burden in children globally. Nevertheless, regional data regarding postpandemic pathogen shifts, coinfection profiles, and risk factors associated with severe pediatric ARTI in Hangzhou, China, remain scarce.
Chao Song, Jun Zhou, Xinfeng Zhao, Cuiying Ye, Shu Teng, Yidong Wu   +5 more
wiley   +1 more source

Application of RDW in Orthopedic Disease

Advances in Clinical Medicine, 2022
openaire   +1 more source

Hematology and Serum Biochemistry Reference Intervals for Captive‐Born Owl Monkeys (Aotus nancymae): Effects of Age and Sex

Journal of Medical Primatology, Volume 55, Issue 4, August 2026.
ABSTRACT Background Owl monkeys (Aotus spp.) are a nocturnal nonhuman primate (NHP) native to central and South America that are used as infectious disease research models for human diseases, such as malaria and human immunodeficiency virus. Natural and infectious diseases may cause alterations in the hematology and serum biochemistry values, which ...
Sarah M. Kezar, Sarah J. Neal, Gregory K. Wilkerson   +2 more
wiley   +1 more source