Results 91 to 100 of about 12,629,330 (263)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Using nominal group technique to identify and prioritize barriers to decentralizing HIV care to primary health centers in Lima, Peru

BMC Health Services Research
Background Decentralizing HIV services is an evidence-based strategy recommended by the World Health Organization to expand healthcare access by shifting most HIV care from specialty (SHCs) to primary health centers (PHCs) with the goal of maximizing ...
David Oliveros, Kelika A. Konda, Lynn M. Madden, Juan José Montenegro-Idrogo, Karla T. Tafur Quintanilla, Karin Sosa Barbarán, Benjamin M. Nikitin, Matthew Ponticiello, Carlos M. Benites, Jorge Sánchez, Frederick L. Altice   +10 more
doaj   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Navigating the completing cancer treatment incentive in Malaysia: patient insights and implementation challenges

BMC Health Services Research
Background Cancer diagnosis imposes a significant economic burden on healthcare systems, patients, and their families particularly those from low-income households.
Nur Hidayati Abdul Halim, Nur Azmiah Zainuddin, Farhana Aminuddin, Nurul Athirah Naserrudin, Nor Zam Azihan Mohd Hassan   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Comparing Two Food is Medicine Trials Using the RE-AIM Framework

ABSTRACT Introduction Food is Medicine (FIM) interventions, such as medically tailored meals, groceries, and produce prescriptions, are increasingly embedded in healthcare delivery.
Bridget Simon-Friedt, Rachel G. Tabak, Sylvester Tumusiime, Lindsey Rudov, Sang Gune K. Yoo, Stephanie Mazzucca-Ragan, Allison Primo, Derek Hashimoto, Adam Hively, Lingxiu Dong, Mark D. Huffman, Thomas W. Carton, Jing Li   +12 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Implementation findings from a hybrid III implementation-effectiveness trial of the Diabetes Prevention Program (DPP) in the Veterans Health Administration (VHA)

Implementation Science, 2017
Background The Diabetes Prevention Program (DPP) is an effective lifestyle intervention to reduce incidence of type 2 diabetes. However, there are gaps in knowledge about how to implement DPP.
Laura J. Damschroder, Caitlin M. Reardon, Mona AuYoung, Tannaz Moin, Santanu K. Datta, Jordan B. Sparks, Matthew L. Maciejewski, Nanette I. Steinle, Jane E. Weinreb, Maria Hughes, Lillian F. Pinault, Xinran M. Xiang, Charles Billington, Caroline R. Richardson   +13 more
doaj   +1 more source