Results 101 to 110 of about 12,629,330 (263)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

SUBVERSIVE FLORI.CULTURES. Ecological manoeuvres from the re-existing South

, 2017
The article deals with the need to approach a decolonial critique of the notion of nature, both in its theoretical and methodological dimension, since it has been clearly reified by Western scientific knowledge to sustain inequalities of power or the ...
Romero Caballero, Belén
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Implementation of a mobile prosthetic and orthotic care program in the VA; a qualitative study of implementation challenges and associated strategies for improvement

Frontiers in Health Services
IntroductionAnticipating and addressing implementation challenges is critical to ensuring success of mobile healthcare programs. Mobile Prosthetic and Orthotic (O&P) Care (MoPOC) is a new U.S.
Chelsea Leonard, Chelsea Leonard, Chelsea Leonard, Jessica Young, Jessica Young, Jessica Young, Lauren McKown, Lauren McKown, Carolyn Klassen, Carolyn Klassen, George E. Kaufman, Daniel Abrahamson   +11 more
doaj   +1 more source

Beyond Evaluation: Using the RE-AIM Framework for Program Planning in Extension

Journal of Extension, 2019
Extension professionals need to apply sound frameworks to program planning and evaluation in order to demonstrate strong population health impact and value. Pragmatic application of the RE-AIM (reach, effectiveness, adoption, implementation, maintenance) framework addresses the "who, what, when, where, how, and why" of a program's implementation.
Balis, Laura E., John, Deborah H., Harden, Samantha M.   +2 more
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

FLORI.CULTURAS SUBVERSIVAS Maniobras ecológicas desde el Sur re-existente

, 2017
El texto trata sobre la necesidad de abordar una crítica descolonial a la noción de naturaleza, tanto en su dimensión teórica como metodológica, pues ha sido claramente reificada por el conocimiento científico occidental para sostener desigualdades de ...
Romero Caballero, Belén
core   +12 more sources

Construction of the Evaluation System of Cognitive Impairment Screening Service in the Community Based on RE-AIM Framework [PDF]

Zhongguo quanke yixue
Background China has now launched the Alzheimer's disease prevention and treatment promotion action, and local communities are actively carrying out cognitive function screening around the community elderly population.
PANG Ting, LI Wanxin, ZHANG Haoran, LIN Zhiying, XU Xin
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source