Results 101 to 110 of about 7,506,517 (292)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Disequilibrium-induced initial Os isotopic heterogeneity in gram aliquots of single basaltic rock powders: Implications for dating and source tracing

open access: yes, 2015
The Re–Os isotopic heterogeneity of mantle-derived rocks has been well documented. However, it is unclear whether and how the Os isotopic heterogeneity of a mantle source can influence Re–Os isotopic dating and source tracing of mantle-derived melts ...
Wang, Q.   +10 more
core   +1 more source

Views on interracial dating among Chinese and European Canadians: The roles of culture, gender, and mainstream cultural identity [PDF]

open access: yes, 2007
The present study examines cross-cultural and gender differ-ences in the norms regarding interracial dating among Chinese and European Canadians. In response to a scenario describing an interracial dating conflict between a young adult and his/her ...
Lynda Cheng   +5 more
core   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

The Age and Sedimentary Environment of the Kunyang Phosphate Deposit, Central Yunnan: Constraints from Re-Os Isotopes

open access: yesYankuang ceshi, 2018
BACKGROUND The Kunyang phosphate deposit in central Yunnan is the largest marine sedimentary phosphorite deposit in China. The deposit is hosted in black shale of the Lower Cambrian Meishucun Formation.
YAN Qing-gao   +5 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Age and Source of the Jinjingzui Skarn-Type Gold Deposit in the Southeastern Hubei Province, China

open access: yesApplied Sciences
The Jinjingzui gold (Au) deposit is located in the central part of Edong, China. The theoretical gold reserves are large with significant potential for mining and future development.
Yan Li   +3 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

open access: yesFEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson   +2 more
wiley   +1 more source

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