Results 111 to 120 of about 99,443 (295)

The ‘Lost’ Church of Bix Gibwyn: The Human Bone [PDF]

open access: yes, 2011
Recent research for the Victoria County History (VCH) highlighted the presence of a ‘lost’ medieval church in Bix, a Chilterns parish north-west of Henley-on-Thames.
Mileson, S.   +2 more
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

The Age and Sedimentary Environment of the Kunyang Phosphate Deposit, Central Yunnan: Constraints from Re-Os Isotopes

open access: yesYankuang ceshi, 2018
BACKGROUND The Kunyang phosphate deposit in central Yunnan is the largest marine sedimentary phosphorite deposit in China. The deposit is hosted in black shale of the Lower Cambrian Meishucun Formation.
YAN Qing-gao   +5 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Age and Source of the Jinjingzui Skarn-Type Gold Deposit in the Southeastern Hubei Province, China

open access: yesApplied Sciences
The Jinjingzui gold (Au) deposit is located in the central part of Edong, China. The theoretical gold reserves are large with significant potential for mining and future development.
Yan Li   +3 more
doaj   +1 more source

Highly Siderophile Elements as Tracers for the Subcontinental Mantle Evolution Beneath the Southwestern USA: The San Carlos and Kilbourne Hole Peridotite Xenoliths Revisited [PDF]

open access: yes
Peridotite xenoliths from San Carlos, Arizona, and Kilbourne Hole, New Mexico, have been studied since the 1970 s to give insights into melting and metasomatism in the subcontinental mantle beneath the southwestern USA.
Brandon, A. D.   +3 more
core   +1 more source

Natural environment and settlement in Chonge District, Eastern Muri Mountains, Northeastern Nigeria : an interdisciplinary case study [PDF]

open access: yes, 2006
The craggy and hilly Muri Mountains, which are situated to the north of the Benue Lowlands, are an area with a complex pattern of settlement. This roughly 80 km long and 20 km wide mountainous area is inhabited by about 20 ethnic groups belonging to ...
Adelberger, Jörg   +2 more
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

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