Results 71 to 80 of about 7,506,517 (292)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Overview on the Re-Os isotopic method and its application on ore deposits and organic-rich rocks [PDF]

Geochimica Brasiliensis, 2013
The Re-Os method has in the last twenty years experienced outstanding improvements and is now widely applied in earth science studies. The unique geochemical characteristics of the isotopic pair allow its application on investigations that vary from ...
Juliana Charão Marques
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Geochemical, microthermometric, and geochronological characterization of the newly discovered Binnan molybdenum deposit in the great Xing’an Range, northeast China: insights into ore genesis

Frontiers in Earth Science
In this paper, the Binnan molybdenum (Mo) deposit, a newly discovered deposit located in the Great Xing’an Range, eastern section of the Central Asian Orogenic Belt, has been subjected to a comprehensive integrated study involving field surveys, rhenium ...
Zhongyou Qi, Shipan Tian, Guibin Sun, Gang Sun, Alam Masroor, Xiaoyu Li, Bingying Du   +6 more
doaj   +1 more source

Application of the 190Pt-186Os isotope decay system to dating platinum-group minerals [PDF]

, 2010
Constraining the formation age of platinum-group minerals (PGM) in placer deposits has traditionally been very challenging. The 190Pt-186Os decay system, measured by laser ablation multi-collector ICPMS (LA-MC-ICPMS), has been demonstrated as a useful ...
Coggon, Judith Ann, COGGON, JUDITH,ANN
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Late Triassic E-W striking shear zone and its implication on gold mineralization in the Xiaoqinling area, eastern China

Frontiers in Earth Science
The Xiaoqinling area is located in the eastern part of the Qinling Orogen and experiences early and late Mesozoic gold mineralization controlled by structural deformation. The relationship between the two stages of mineralization and the orogenic process
Hong Chen, Gui-Fan Zhu, He Bai, Guo-Shuai Cui, Huan-Huan Zhang, Pei-Ji Mu, Yong-Jie Jin   +6 more
doaj   +1 more source

Re-os isotope constraints on the age of the Lithospheric mantle beneath western Greenland. [PDF]

, 2007
Alkaline magmatic activity across Western Greenland (W.G.) provides a record of lithosphere evolution over the last 600 Ma. Ultra Mafic Lamprophyre (UML) magmatism in particular has erupted an exceptional inventory of mantle xenoliths allowing a detailed
Webb, Michelle
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source