Results 191 to 200 of about 7,532,149 (298)

Metabolic reprogramming-related drug resistance in osteosarcoma: from molecular mechanisms to therapeutic translation. [PDF]

Front Mol Biosci
Wu Q, Chen H, Li J.
europepmc   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source

Advances in Transarterial Radionuclide Therapy for Hepatocellular Carcinoma and Other Liver Tumors: From Yttrium-90 Radioembolization to Emerging Lipiodol-Based Theranostic Approaches. [PDF]

Molecules
Kono Y, Utsunomiya K, Kariya S, Tanigawa N.   +3 more
europepmc   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Olivine and Fe-isotopes in kimberlites indicate an iron-rich substrate for CLIPPIR and other sub-lithospheric diamonds. [PDF]

Nat Commun
Howarth GH, Giuliani A, Tau MM, Cai R, Liu J.   +4 more
europepmc   +1 more source

Understanding and Regulating C–N Coupling Pathways for Electrocatalytic Urea Synthesis From CO2 and NO3−/NO2−

Advanced Science, EarlyView.
Understanding and regulating C–N coupling is central to electrocatalytic urea synthesis from CO2 and NO3−/NO2−. This review outlines representative coupling pathways, summarizes carbon‐ and nitrogen‐side intermediate regulation strategies, and highlights in situ/operando tools for mechanistic clarification and catalyst design. ABSTRACT Electrocatalytic
Xingbao Chen, Zhuo Li, Lebin Cai, Paul Kilmartin, Bao Yu Xia, Ziyun Wang   +5 more
wiley   +1 more source

Discovery of White Sea assemblage fossils from Laurentia. [PDF]

Sci Adv
Evans SD, Sperling EA, Lau KV, Strauss JV.   +3 more
europepmc   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

Earth orbital rhythms links timing of Deccan trap volcanism phases and global climate change. [PDF]

Sci Adv
Westerhold T, Dallanave E, Penman D, Schoene B, Röhl U, Gussone N, Kuroda J.   +6 more
europepmc   +1 more source

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source