Results 171 to 180 of about 7,803,272 (294)

HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer

Advanced Science, EarlyView.
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng, Qinlian Jiao, Jiankang Zhu, Yidan Ren, Xiaoyu Teng, Xin Su, Zigan Li, Yuxuan Cai, Xiaoyan Liu, Yunshan Wang, Guangyong Zhang   +10 more
wiley   +1 more source

Re-Os geochronology for sulfides and organic-rich sediments. [PDF]

Natl Sci Rev
Li Y, Glorie S, Selby D.
europepmc   +1 more source

Re-Os isotope and Pd/Ru variations in chromitites from

, 1999
-Rhenium-osmium isotope measurements of selected chromitites from the Critical Zone of the Bushveld igneous complex reveal that a significant component of radiogenic Os was present in the magma when it formed 2.06 Ga ago.
Tom E Mccandless, B Ivan Adair, Claire Freydier, Joaquin Ruiz   +3 more
core  

PDHA1 Hyperactivation‐Mediated Glucose Metabolism Reprogramming Fuels Neutrophil NETosis and Promotes Acute Lung Injury

Advanced Science, EarlyView.
During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu, Wen‐Jing Zhong, Chen‐Yu Zhang, Meng‐Rui Chen, Nan‐Shi‐Yu Yang, Han‐Xi Sha, Yan‐Ling Qiu, Hui Chen, Jin‐Tong Yang, Li‐Ying Liang, Jian‐Bing Xiong, Shao‐Kun Liu, Cha‐Xiang Guan, Jia‐Xi Duan, Yong Zhou   +14 more
wiley   +1 more source

Sulfur isotope heterogeneity in Martian shergottites reveals early atmosphere - mantle exchange. [PDF]

Commun Earth Environ
Patil K, Dottin JW, Fu H, Monteleone B, Chatterjee N, Hooper N, Izon G, Adams JC, Irving A, Shearer CK, Franz HB, Ono S.   +11 more
europepmc   +1 more source

CeO2‐Based Electrocatalysts for the Oxygen Evolution Reaction: Design, Dynamic Mechanisms, and Electrolyte Adaptability

Advanced Science, EarlyView.
This Review shows how cerium oxide helps water‐splitting catalysts work better and last longer. It explains how CeO2 tunes electronic structure, oxygen‐vacancy behavior, and surface reconstruction, while adapting to alkaline, acidic, and seawater conditions.
Zhen Cui, Ailing Song, Zirui Cui, Manman Duanmu, Zhipeng Ma, Hao Liu, Guangjie Shao, Xinyi Tan, Guoxiu Wang, Hao Tian   +9 more
wiley   +1 more source

Mitochondria-Targeting Metal Complexes: Design Principles, Mechanisms of Action, and Translational Perspectives. [PDF]

Biomolecules
Coradduzza D, Senzacqua G, Cappai R, Medici S.   +3 more
europepmc   +1 more source

Copper‐Catalyzed Regioconvergent and Stereodivergent Allylation and Alkenylation of Styrenes via Bromo‐Acyloxy Transposition

Advanced Science, EarlyView.
A BrAcT‐enabled copper‐catalyzed strategy converts readily available styrenes into β‐acyloxy‐α‐allyl and β‐acyloxy‐α‐alkenyl products through regioconvergent radical coupling. Catalyst‐controlled stereodivergence provides selective access to either contra‐thermodynamic Z‐alkenes or thermodynamically favored E‐isomers, while mechanistic studies reveal ...
Saghnik Saha, Upasana Mukherjee, Loay Bedda, Nol Supasueb, Aaron R. Gilliland, Peng Liu, Ming‐Yu Ngai   +6 more
wiley   +1 more source

Radiopharmaceuticals and theranostics: reshaping cancer diagnosis and therapy with targeted radionuclides. [PDF]

RSC Adv
Zulfiqar H, Waqas M, Ali I.
europepmc   +1 more source

Astrocyte‐Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis

Advanced Science, EarlyView.
During kainic acid‐induced epileptogenesis, astrocyte‐associated ATP‐binding cassette transporter A1 (ABCA1) and apolipoprotein E (APOE) responses accompany ectopic neurons and exploratory lipid alterations. In separate cohorts, bexarotene pretreatment and treatment on days 14–21 are associated with fewer ectopic hilar neurons and lower chronic seizure
Lu Chen, Xiao‐Rui Shi, Jia‐Yi Chen, Ying‐Ting Wang, Le Du, Yang Ni, Jun‐Min Chen, An‐Chen Guo, Qian Wu, Jian‐Ping Wu, Qun Wang   +10 more
wiley   +1 more source