Results 231 to 240 of about 7,803,272 (294)

AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective

Advanced Intelligent Discovery, EarlyView.
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley   +1 more source

Multidisciplinary evidence for synchroneity between Ontong Java Nui volcanism and early Aptian oceanic anoxic event 1a. [PDF]

Sci Adv
Matsumoto H, Shirai K, Ishikawa A, Ohkouchi N, Ogawa NO, Tejada MLG, Ando A, Kuroda J, Suzuki K.   +8 more
europepmc   +1 more source

Catalyst‐Specialized Chemical Language Model Based on Transformer Variational Autoencoder for Catalyst Design and Discovery

Advanced Intelligent Discovery, EarlyView.
We present CatTransVAE, a catalyst‐specialized chemical language model (CLM) built on a transformer variational autoencoder (VAE), developed through pretraining on general compounds followed by fine‐tuning on diverse catalyst databases. A template‐guided generation framework is introduced to enable controlled catalyst design under structural ...
Apakorn Kengkanna, Masahito Ohue
wiley   +1 more source

Isotopic H/D Exchange in Hydrogen Bonds Between the Nitrogenous Bases of the CAG Repeat Tract Makes It Possible to Stabilize Its Expansion in the <i>ATXN2</i> Gene. [PDF]

Biomedicines
Dorohova A, Velázquez-Pérez L, Drobotenko M, Lyasota O, Hernandez-Caceres JL, Rodriguez-Labrada R, Svidlov A, Leontyeva O, Nechipurenko Y, Dzhimak S.   +9 more
europepmc   +1 more source

A mid‐Cretaceous monocot flower from the Dakota Sandstone of Kansas and its potential implications for the fossil record of palms

American Journal of Botany, EarlyView.
Abstract Premise Although the megafossil flora of the upper Albian–lower Cenomanian Dakota Formation in Kansas is well known for angiosperms, monocots have not been reported previously. Methods A mesofossil flower was discovered by X‐ray analysis of a specimen collected more than a century ago from the Dakota Sandstone of central Kansas.
Bruce H. Tiffney, Walter S. Judd, William J. Baker, John Dransfield, Steven R. Manchester   +4 more
wiley   +1 more source

Scout-Triggered Multiple Reaction Monitoring Enables Robust Quantification of Host Cell Proteins Across Bioprocess Matrices. [PDF]

Proteomes
Flecheux J, Bardet C, Herment L, Fortin T, Lemoine J.   +4 more
europepmc   +1 more source

Construction Trade Work Is Associated With Accelerated Decline in Kidney Function

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Construction workers are exposed to airborne particulates, organic solvents, and metals—agents linked to elevated risk of chronic kidney disease (CKD). Few studies have evaluated whether construction trade work is associated with longitudinal changes in estimated glomerular filtration rate (eGFR), a key indicator of kidney function.
Sammy Almashat, John M. Dement, Marianne Cloeren, Knut Ringen, Miles Fisher, Richard Rinehart   +5 more
wiley   +1 more source

The Boron-Neuron Connection: The Potential of Boron-Containing Molecules for Treating Incurable Amyotrophic Lateral Sclerosis. [PDF]

ChemMedChem
Sanghai N, Vuong B, Afridi MSK, Leggett S, Roghzai H, Tranmer GK.   +5 more
europepmc   +1 more source

Molecular Details of RNA Interactions With FUS Condensates Altering Assembly, Dynamics, and Aggregation

Angewandte Chemie, EarlyView.
Using NMR and molecular simulations, we map how RNA engages FUS LC‐RGG1 within condensates through electrostatic, π‐stacking, and polar contacts. These multivalent RNA contacts help stabilize RNA within FUS condensates while also reshaping condensate composition and dynamics.
Tongyin Zheng, Kandarp A. Sojitra, Samara Cummings, Qizan Chen, Priyesh Mohanty, Jeetain Mittal, Nicolas L. Fawzi   +6 more
wiley   +1 more source

Physeal breach as a potential predictor of pulmonary metastasis in paediatric osteosarcoma. [PDF]

Front Oncol
Lin Z, Huang P, Shan J, Qi Z, Liang M, Cao B, Ning B.   +6 more
europepmc   +1 more source