Results 81 to 90 of about 127,676 (332)

Glucocorticoids Alter Bone Microvascular Barrier via MAPK/Connexin43 Mechanisms

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Osteoporosis induced by Glucocorticoids (GCs) is a common complication of long‐term GC use in patients with inflammatory and autoimmune conditions, often leading to an increased fracture risk. A 3D bicellular endo‐osteo microfluidic platform is developed to explore pathogenic mechanisms underlying GCs‐induced osteoporosis, highlighting a novel MAPK ...
Eun‐Jin Lee, Peter Lialios, Micaila Curtis, James Williams IV, Yoontae Kim, Paul Salipante, Steven Hudson, Mandy B. Esch, Moshe Levi, Joanna Kitlinska, Stella Alimperti   +10 more
wiley   +1 more source

Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2. [PDF]

, 2018
The concentration of glucose in plasma is held within narrow limits (4-10 mmol/l), primarily to ensure fuel supply to the brain. Kidneys play a role in glucose homeostasis in the body by ensuring that glucose is not lost in the urine.
Ghezzi, Chiara, Loo, Donald DF, Wright, Ernest M   +2 more
core  

Aspects of particle production in isospin asymmetric matter

, 2005
The production/absorption rate of particles in compressed and heated asymmetric matter is studied using a Relativistic Mean Field (RMF) transport model with an isospin dependent collision term.
Aichelin, Baran, Bratkovskaya, Bratkovskaya, Cassing, Chen, Cugnon, Danielewicz, Danielewicz, de Jong, Fang, Fuchs, Fuchs, Fuchs, G. Ferini, Gaitanos, Gaitanos, Gaitanos, Gaitanos, Greco, Gross-Boelting, Hong, Huber, Kubis, Lang, Larionov, Laue, Li, Li, Li, Liu, Liu, M. Colonna, M. Di Toro, Pinkenburg, Reiter, Sahu, Serot, Sturm, T. Gaitanos, ter Haar, Tsushima, Tsushima, Tsushima, van Dalen, van Dalen, Weber   +46 more
core   +1 more source

Analysis of efficacy of SGLT2 inhibitors using semi-mechanistic model

Frontiers in Pharmacology, 2014
Renal sodium-dependent glucose co-transporter 2 (SGLT2) is one of the most promising targets for the treatment of type 2 diabetes. Two SGLT2 inhibitors, dapagliflozin and canagliflozin, have already been approved for use in USA and Europe; several ...
Oleg eDemin Jr, Tatiana eYakovleva, Dmitry eKolobkov, Oleg eDemin   +3 more
doaj   +1 more source

Increased Glomerular Hydrostatic Pressure is Associated with Tubular Creatinine Reabsorption in Healthy Subjects

Kidney & Blood Pressure Research, 2020
Background: Cr is secreted by the proximal tubules and thus Cr clearance (Ccr) can overestimate inulin clearance (Cin). However, in some cases, Ccr can even underestimate Cin. This suggests that Cr could be reabsorbed in the tubuli.
Akihiro Tsuda, Eiji Ishimura, Yuri Machiba, Hideki Uedono, Shinya Nakatani, Katsuhito Mori, Junji Uchida, Masanori Emoto   +7 more
doaj   +1 more source

An Animal‐Free Patient‐Derived Tissue‐Mimetic Biochip Model of the Human Synovial Membrane for Human‐Relevant Osteoarthritis Research

Advanced Healthcare Materials, EarlyView.
Reihs et al. present the development of a humanized, animal‐free synovial membrane model for osteoarthritis. Methods include 3D biochip cultures of human‐primary OA synoviocytes with matrix and serum surrogates. Results show replication of synovial architecture and increased Yap1 expression.
Eva I. Reihs, Alexander Stoegner, Mateo G. Vasconez Martínez, Markus M. Schreiner, Melanie Cezanne, Ruth Gruebl‐Barabas, Bettina Rodriguez‐Molina, Juergen Alphonsus, Silvia Hayer, Richard Lass, Iris Gerner, Florien Jenner, Wolfgang Holnthoner, Stefan Toegel, Peter Ertl, Hans P. Kiener, Reinhard Windhager, Mario Rothbauer   +17 more
wiley   +1 more source

Characterization of coal products from high temperature processing of Usibelli low-rank coals [PDF]

, 1991
This research project was conducted in association with Gilbert/Commonwealth Inc. as part of an overall techno-economic assessment of high temperature drying of low-rank coals. This report discusses the characteristics of the dried/pyrolyzed products of
Li, YuFu, Rao, P.D., Walsh, D.E., Wilson, W.   +3 more
core  

Claudins in the Renal Collecting Duct [PDF]

, 2019
The renal collecting duct fine-tunes urinary composition, and thereby, coordinates key physiological processes, such as volume/blood pressure regulation, electrolyte-free water reabsorption, and acid-base homeostasis.
Leiz, Janna, Schmitt-Ott, Kai M.
core   +1 more source

Diuretic Agents and Glucose Reabsorption

Experimental Biology and Medicine, 1975
Acetazolamide, chlorothiazide, ethacrynic acid and furosemide were infused to glucose loaded dogs. Glucose reasorption was unchanged after acetazolamide and chlorothiazide. Ethacrynic acid depressed glucose reabsorption significantly. Furosemide caused a modest decrease in glucose reabsorption which was not significant when the control values were ...
Luis F. Gutierrez, Neil A. Kurtzman, Jose A.L. Arruda   +2 more
openaire   +3 more sources

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, EarlyView.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source