Results 101 to 110 of about 2,798,523 (312)
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Maine-Wabanaki REACH Newsletter, Winter 2017
, 2017 This quarter\u27s cover story discusses the ongoing mission of Wabanaki REACH to provide learning and healing programs. Over 1,800 participants engaged in REACH programming during 2017.
Wabanaki REACH
core +1 more source
, 2014 32 FolienDie weltweit gesetzlichen Umweltvorschriften sind komplex, länderspezifisch und erfordern ein hohes Maß an Flexibilität. Sie haben jedoch alle ein gemeinsames Ziel: ein hohes Schutzniveau für die menschliche Gesundheit und für die Umwelt ...
Hornberger, Markus
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Evaluating the Influence of Disinformation Narratives on a Divisive Election Campaign
Communication & Society (Formerly Comunicación y Sociedad)Despite extensive research on disinformation, its societal impact remains uncertain. Previous studies have primarily focused on the spread of disinformation, especially on platforms like Twitter, or on how exposure influences attitudes.
Jaume Suau Martínez +2 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Phenylketonuria as an Adherence Disease
Patient Preference and AdherenceGérard Reach Health Education and Promotion Laboratory, Sorbonne Paris Nord University, Bobigny, FranceCorrespondence: Gérard Reach, Health Education and Promotion Laboratory, Sorbonne Paris Nord University, 74 Rue Marcel Cachin, Bobigny, 93000, France ...
Reach G
doaj
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
, 2018 Despite its well-described safety and efficacy in the treatment of sickle cell anemia (SCA) in high-income settings, hydroxyurea remains largely unavailable in sub-Saharan Africa, where more than 75% of annual SCA births occur and many comorbidities ...
REACH Investigators +35 more
core +2 more sources
Evaluating the Integrated Geriatric Care Program in a Health Center in Yazd, Iran, Based on the RE-AIM Framework [PDF]
SālmandObjectives Today, geriatric care is one of the most important issues in health systems. The present study aimed to evaluate the integrated geriatric care program (IGCP) in a health center in Yazd, Iran, based on the reach, effectiveness, adoption ...
Neda Sadat Nazaripanah +3 more
doaj
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source